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A human fetal liver-derived infant MLL-AF4 acute lymphoblastic leukemia model reveals a distinct fetal gene expression program.

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Title: A human fetal liver-derived infant MLL-AF4 acute lymphoblastic leukemia model reveals a distinct fetal gene expression program.
Authors: Rice S; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, NIHR Oxford Biomedical Research Centre Haematology Theme, Radcliffe Department of Medicine, University of Oxford, Oxford, UK., Jackson T; Department of Paediatrics and NIHR Oxford Biomedical Research Centre Haematology Theme, University of Oxford, Oxford, UK., Crump NT; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, NIHR Oxford Biomedical Research Centre Haematology Theme, Radcliffe Department of Medicine, University of Oxford, Oxford, UK., Fordham N; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, NIHR Oxford Biomedical Research Centre Haematology Theme, Radcliffe Department of Medicine, University of Oxford, Oxford, UK., Elliott N; Department of Paediatrics and NIHR Oxford Biomedical Research Centre Haematology Theme, University of Oxford, Oxford, UK., O'Byrne S; Department of Paediatrics and NIHR Oxford Biomedical Research Centre Haematology Theme, University of Oxford, Oxford, UK., Fanego MDML; Department of Haematology, Great Ormond Street Hospital for Children, London, UK., Addy D; Department of Haematology, Great Ormond Street Hospital for Children, London, UK., Crabb T; Department of Haematology, Great Ormond Street Hospital for Children, London, UK., Dryden C; Department of Haematology, Great Ormond Street Hospital for Children, London, UK., Inglott S; Department of Haematology, Great Ormond Street Hospital for Children, London, UK., Ladon D; Department of Haematology, Great Ormond Street Hospital for Children, London, UK., Wright G; Department of Haematology, Great Ormond Street Hospital for Children, London, UK., Bartram J; Department of Haematology, Great Ormond Street Hospital for Children, London, UK., Ancliff P; Department of Haematology, Great Ormond Street Hospital for Children, London, UK., Mead AJ; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, NIHR Oxford Biomedical Research Centre Haematology Theme, Radcliffe Department of Medicine, University of Oxford, Oxford, UK., Halsey C; Wolfson Wohl Cancer Research Centre, Institute of Cancer Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.; Department of Paediatric Haematology, Royal Hospital for Children, Glasgow, UK., Roberts I; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, NIHR Oxford Biomedical Research Centre Haematology Theme, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.; Department of Paediatrics and NIHR Oxford Biomedical Research Centre Haematology Theme, University of Oxford, Oxford, UK., Milne TA; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, NIHR Oxford Biomedical Research Centre Haematology Theme, Radcliffe Department of Medicine, University of Oxford, Oxford, UK. thomas.milne@imm.ox.ac.uk., Roy A; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, NIHR Oxford Biomedical Research Centre Haematology Theme, Radcliffe Department of Medicine, University of Oxford, Oxford, UK. anindita.roy@paediatrics.ox.ac.uk.; Department of Paediatrics and NIHR Oxford Biomedical Research Centre Haematology Theme, University of Oxford, Oxford, UK. anindita.roy@paediatrics.ox.ac.uk.
Source: Nature communications [Nat Commun] 2021 Nov 25; Vol. 12 (1), pp. 6905. Date of Electronic Publication: 2021 Nov 25.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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  Data: A human fetal liver-derived infant MLL-AF4 acute lymphoblastic leukemia model reveals a distinct fetal gene expression program.
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  Data: <searchLink fieldCode="AU" term="%22Rice+S%22">Rice S</searchLink>; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, NIHR Oxford Biomedical Research Centre Haematology Theme, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Jackson+T%22">Jackson T</searchLink>; Department of Paediatrics and NIHR Oxford Biomedical Research Centre Haematology Theme, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Crump+NT%22">Crump NT</searchLink>; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, NIHR Oxford Biomedical Research Centre Haematology Theme, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Fordham+N%22">Fordham N</searchLink>; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, NIHR Oxford Biomedical Research Centre Haematology Theme, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Elliott+N%22">Elliott N</searchLink>; Department of Paediatrics and NIHR Oxford Biomedical Research Centre Haematology Theme, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22O'Byrne+S%22">O'Byrne S</searchLink>; Department of Paediatrics and NIHR Oxford Biomedical Research Centre Haematology Theme, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Fanego+MDML%22">Fanego MDML</searchLink>; Department of Haematology, Great Ormond Street Hospital for Children, London, UK.<br /><searchLink fieldCode="AU" term="%22Addy+D%22">Addy D</searchLink>; Department of Haematology, Great Ormond Street Hospital for Children, London, UK.<br /><searchLink fieldCode="AU" term="%22Crabb+T%22">Crabb T</searchLink>; Department of Haematology, Great Ormond Street Hospital for Children, London, UK.<br /><searchLink fieldCode="AU" term="%22Dryden+C%22">Dryden C</searchLink>; Department of Haematology, Great Ormond Street Hospital for Children, London, UK.<br /><searchLink fieldCode="AU" term="%22Inglott+S%22">Inglott S</searchLink>; Department of Haematology, Great Ormond Street Hospital for Children, London, UK.<br /><searchLink fieldCode="AU" term="%22Ladon+D%22">Ladon D</searchLink>; Department of Haematology, Great Ormond Street Hospital for Children, London, UK.<br /><searchLink fieldCode="AU" term="%22Wright+G%22">Wright G</searchLink>; Department of Haematology, Great Ormond Street Hospital for Children, London, UK.<br /><searchLink fieldCode="AU" term="%22Bartram+J%22">Bartram J</searchLink>; Department of Haematology, Great Ormond Street Hospital for Children, London, UK.<br /><searchLink fieldCode="AU" term="%22Ancliff+P%22">Ancliff P</searchLink>; Department of Haematology, Great Ormond Street Hospital for Children, London, UK.<br /><searchLink fieldCode="AU" term="%22Mead+AJ%22">Mead AJ</searchLink>; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, NIHR Oxford Biomedical Research Centre Haematology Theme, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Halsey+C%22">Halsey C</searchLink>; Wolfson Wohl Cancer Research Centre, Institute of Cancer Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.; Department of Paediatric Haematology, Royal Hospital for Children, Glasgow, UK.<br /><searchLink fieldCode="AU" term="%22Roberts+I%22">Roberts I</searchLink>; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, NIHR Oxford Biomedical Research Centre Haematology Theme, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.; Department of Paediatrics and NIHR Oxford Biomedical Research Centre Haematology Theme, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Milne+TA%22">Milne TA</searchLink>; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, NIHR Oxford Biomedical Research Centre Haematology Theme, Radcliffe Department of Medicine, University of Oxford, Oxford, UK. thomas.milne@imm.ox.ac.uk.<br /><searchLink fieldCode="AU" term="%22Roy+A%22">Roy A</searchLink>; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, NIHR Oxford Biomedical Research Centre Haematology Theme, Radcliffe Department of Medicine, University of Oxford, Oxford, UK. anindita.roy@paediatrics.ox.ac.uk.; Department of Paediatrics and NIHR Oxford Biomedical Research Centre Haematology Theme, University of Oxford, Oxford, UK. anindita.roy@paediatrics.ox.ac.uk.
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