Protective mucosal immunity against SARS-CoV-2 after heterologous systemic prime-mucosal boost immunization.

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Title: Protective mucosal immunity against SARS-CoV-2 after heterologous systemic prime-mucosal boost immunization.
Authors: Lapuente D; Institute of Clinical and Molecular Virology, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany. Dennis.Lapuente@uk-erlangen.de., Fuchs J; Institute of Clinical and Molecular Virology, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany., Willar J; Institute of Clinical and Molecular Virology, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany., Vieira Antão A; Institute of Clinical and Molecular Virology, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany., Eberlein V; Department of Immunology, Fraunhofer Institute for Cell Therapy and Immunology, IZI, Leipzig, Germany.; Fraunhofer Cluster of Excellence Immune-mediated Diseases CIMD, Frankfurt am Main, Germany., Uhlig N; Department of Immunology, Fraunhofer Institute for Cell Therapy and Immunology, IZI, Leipzig, Germany.; Fraunhofer Cluster of Excellence Immune-mediated Diseases CIMD, Frankfurt am Main, Germany., Issmail L; Department of Immunology, Fraunhofer Institute for Cell Therapy and Immunology, IZI, Leipzig, Germany.; Fraunhofer Cluster of Excellence Immune-mediated Diseases CIMD, Frankfurt am Main, Germany., Schmidt A; Institute of Clinical and Molecular Virology, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany., Oltmanns F; Institute of Clinical and Molecular Virology, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany., Peter AS; Institute of Clinical and Molecular Virology, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany., Mueller-Schmucker S; Institute of Clinical and Molecular Virology, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany., Irrgang P; Institute of Clinical and Molecular Virology, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany., Fraedrich K; Institute of Clinical and Molecular Virology, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany., Cara A; National Center for Global Health, Istituto Superiore di Sanità, Rome, Italy., Hoffmann M; Infection Biology Unit, German Primate Center-Leibniz Institute for Primate Research, Göttingen, Germany.; Faculty of Biology and Psychology, Georg-August-University Göttingen, Göttingen, Germany., Pöhlmann S; Infection Biology Unit, German Primate Center-Leibniz Institute for Primate Research, Göttingen, Germany.; Faculty of Biology and Psychology, Georg-August-University Göttingen, Göttingen, Germany., Ensser A; Institute of Clinical and Molecular Virology, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany., Pertl C; Sirion Biotech, Martinsried, Germany., Willert T; Sirion Biotech, Martinsried, Germany., Thirion C; Sirion Biotech, Martinsried, Germany., Grunwald T; Department of Immunology, Fraunhofer Institute for Cell Therapy and Immunology, IZI, Leipzig, Germany.; Fraunhofer Cluster of Excellence Immune-mediated Diseases CIMD, Frankfurt am Main, Germany., Überla K; Institute of Clinical and Molecular Virology, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany., Tenbusch M; Institute of Clinical and Molecular Virology, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany. matthias.tenbusch@fau.de.
Source: Nature communications [Nat Commun] 2021 Nov 26; Vol. 12 (1), pp. 6871. Date of Electronic Publication: 2021 Nov 26.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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  Data: Protective mucosal immunity against SARS-CoV-2 after heterologous systemic prime-mucosal boost immunization.
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  Data: <searchLink fieldCode="AU" term="%22Lapuente+D%22">Lapuente D</searchLink>; Institute of Clinical and Molecular Virology, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany. Dennis.Lapuente@uk-erlangen.de.<br /><searchLink fieldCode="AU" term="%22Fuchs+J%22">Fuchs J</searchLink>; Institute of Clinical and Molecular Virology, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany.<br /><searchLink fieldCode="AU" term="%22Willar+J%22">Willar J</searchLink>; Institute of Clinical and Molecular Virology, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany.<br /><searchLink fieldCode="AU" term="%22Vieira+Antão+A%22">Vieira Antão A</searchLink>; Institute of Clinical and Molecular Virology, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany.<br /><searchLink fieldCode="AU" term="%22Eberlein+V%22">Eberlein V</searchLink>; Department of Immunology, Fraunhofer Institute for Cell Therapy and Immunology, IZI, Leipzig, Germany.; Fraunhofer Cluster of Excellence Immune-mediated Diseases CIMD, Frankfurt am Main, Germany.<br /><searchLink fieldCode="AU" term="%22Uhlig+N%22">Uhlig N</searchLink>; Department of Immunology, Fraunhofer Institute for Cell Therapy and Immunology, IZI, Leipzig, Germany.; Fraunhofer Cluster of Excellence Immune-mediated Diseases CIMD, Frankfurt am Main, Germany.<br /><searchLink fieldCode="AU" term="%22Issmail+L%22">Issmail L</searchLink>; Department of Immunology, Fraunhofer Institute for Cell Therapy and Immunology, IZI, Leipzig, Germany.; Fraunhofer Cluster of Excellence Immune-mediated Diseases CIMD, Frankfurt am Main, Germany.<br /><searchLink fieldCode="AU" term="%22Schmidt+A%22">Schmidt A</searchLink>; Institute of Clinical and Molecular Virology, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany.<br /><searchLink fieldCode="AU" term="%22Oltmanns+F%22">Oltmanns F</searchLink>; Institute of Clinical and Molecular Virology, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany.<br /><searchLink fieldCode="AU" term="%22Peter+AS%22">Peter AS</searchLink>; Institute of Clinical and Molecular Virology, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany.<br /><searchLink fieldCode="AU" term="%22Mueller-Schmucker+S%22">Mueller-Schmucker S</searchLink>; Institute of Clinical and Molecular Virology, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany.<br /><searchLink fieldCode="AU" term="%22Irrgang+P%22">Irrgang P</searchLink>; Institute of Clinical and Molecular Virology, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany.<br /><searchLink fieldCode="AU" term="%22Fraedrich+K%22">Fraedrich K</searchLink>; Institute of Clinical and Molecular Virology, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany.<br /><searchLink fieldCode="AU" term="%22Cara+A%22">Cara A</searchLink>; National Center for Global Health, Istituto Superiore di Sanità, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Hoffmann+M%22">Hoffmann M</searchLink>; Infection Biology Unit, German Primate Center-Leibniz Institute for Primate Research, Göttingen, Germany.; Faculty of Biology and Psychology, Georg-August-University Göttingen, Göttingen, Germany.<br /><searchLink fieldCode="AU" term="%22Pöhlmann+S%22">Pöhlmann S</searchLink>; Infection Biology Unit, German Primate Center-Leibniz Institute for Primate Research, Göttingen, Germany.; Faculty of Biology and Psychology, Georg-August-University Göttingen, Göttingen, Germany.<br /><searchLink fieldCode="AU" term="%22Ensser+A%22">Ensser A</searchLink>; Institute of Clinical and Molecular Virology, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany.<br /><searchLink fieldCode="AU" term="%22Pertl+C%22">Pertl C</searchLink>; Sirion Biotech, Martinsried, Germany.<br /><searchLink fieldCode="AU" term="%22Willert+T%22">Willert T</searchLink>; Sirion Biotech, Martinsried, Germany.<br /><searchLink fieldCode="AU" term="%22Thirion+C%22">Thirion C</searchLink>; Sirion Biotech, Martinsried, Germany.<br /><searchLink fieldCode="AU" term="%22Grunwald+T%22">Grunwald T</searchLink>; Department of Immunology, Fraunhofer Institute for Cell Therapy and Immunology, IZI, Leipzig, Germany.; Fraunhofer Cluster of Excellence Immune-mediated Diseases CIMD, Frankfurt am Main, Germany.<br /><searchLink fieldCode="AU" term="%22Überla+K%22">Überla K</searchLink>; Institute of Clinical and Molecular Virology, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany.<br /><searchLink fieldCode="AU" term="%22Tenbusch+M%22">Tenbusch M</searchLink>; Institute of Clinical and Molecular Virology, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany. matthias.tenbusch@fau.de.
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  Data: <searchLink fieldCode="JN" term="%22101528555%22">Nature communications</searchLink> [Nat Commun] 2021 Nov 26; Vol. 12 (1), pp. 6871. <i>Date of Electronic Publication: </i>2021 Nov 26.
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