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Subclone-specific microenvironmental impact and drug response in refractory multiple myeloma revealed by single-cell transcriptomics.

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Title: Subclone-specific microenvironmental impact and drug response in refractory multiple myeloma revealed by single-cell transcriptomics.
Authors: Tirier SM; Division of Chromatin Networks, German Cancer Research Center (DKFZ) and Bioquant, Heidelberg, Germany., Mallm JP; Division of Chromatin Networks, German Cancer Research Center (DKFZ) and Bioquant, Heidelberg, Germany.; Single Cell Open Lab, German Cancer Research Center (DKFZ) and Bioquant, Heidelberg, Germany.; Molecular Precision Oncology Program, NCT Heidelberg, Heidelberg, Germany., Steiger S; Division of Chromatin Networks, German Cancer Research Center (DKFZ) and Bioquant, Heidelberg, Germany., Poos AM; University Hospital Heidelberg, Internal Medicine V, Heidelberg, Germany.; CCU Molecular Hematology/Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany., Awwad MHS; University Hospital Heidelberg, Internal Medicine V, Heidelberg, Germany., Giesen N; University Hospital Heidelberg, Internal Medicine V, Heidelberg, Germany.; CCU Molecular Hematology/Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany., Casiraghi N; Division of Computational Genomics and System Genetics, German Cancer Research Center (DKFZ), Heidelberg, Germany.; European Molecular Biology Laboratory (EMBL), Genome Biology Unit, Heidelberg, Germany., Susak H; Division of Computational Genomics and System Genetics, German Cancer Research Center (DKFZ), Heidelberg, Germany.; European Molecular Biology Laboratory (EMBL), Genome Biology Unit, Heidelberg, Germany., Bauer K; Single Cell Open Lab, German Cancer Research Center (DKFZ) and Bioquant, Heidelberg, Germany.; Molecular Precision Oncology Program, NCT Heidelberg, Heidelberg, Germany., Baumann A; CCU Molecular Hematology/Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany., John L; University Hospital Heidelberg, Internal Medicine V, Heidelberg, Germany.; CCU Molecular Hematology/Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany., Seckinger A; University Hospital Heidelberg, Internal Medicine V, Heidelberg, Germany.; Department of Hematology and Immunology, Myeloma Center Brussels, Jette, Belgium., Hose D; University Hospital Heidelberg, Internal Medicine V, Heidelberg, Germany.; Department of Hematology and Immunology, Myeloma Center Brussels, Jette, Belgium., Müller-Tidow C; University Hospital Heidelberg, Internal Medicine V, Heidelberg, Germany., Goldschmidt H; University Hospital Heidelberg, Internal Medicine V, Heidelberg, Germany.; National Center for Tumor Diseases (NCT), Heidelberg, Germany., Stegle O; Division of Computational Genomics and System Genetics, German Cancer Research Center (DKFZ), Heidelberg, Germany.; European Molecular Biology Laboratory (EMBL), Genome Biology Unit, Heidelberg, Germany., Hundemer M; University Hospital Heidelberg, Internal Medicine V, Heidelberg, Germany., Weinhold N; University Hospital Heidelberg, Internal Medicine V, Heidelberg, Germany.; CCU Molecular Hematology/Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany., Raab MS; University Hospital Heidelberg, Internal Medicine V, Heidelberg, Germany. marc.raab@med.uni-heidelberg.de.; CCU Molecular Hematology/Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany. marc.raab@med.uni-heidelberg.de., Rippe K; Division of Chromatin Networks, German Cancer Research Center (DKFZ) and Bioquant, Heidelberg, Germany. karsten.rippe@dkfz.de.
Source: Nature communications [Nat Commun] 2021 Nov 29; Vol. 12 (1), pp. 6960. Date of Electronic Publication: 2021 Nov 29.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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