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Multiplex CRISPR/Cas9 genome editing in hematopoietic stem cells for fetal hemoglobin reinduction generates chromosomal translocations.

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Title: Multiplex CRISPR/Cas9 genome editing in hematopoietic stem cells for fetal hemoglobin reinduction generates chromosomal translocations.
Authors: Samuelson C; Stem Cell and Gene Therapy Program, Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109-1024, USA., Radtke S; Stem Cell and Gene Therapy Program, Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109-1024, USA., Zhu H; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA 98195, USA., Llewellyn M; Stem Cell and Gene Therapy Program, Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109-1024, USA., Fields E; Stem Cell and Gene Therapy Program, Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109-1024, USA., Cook S; Stem Cell and Gene Therapy Program, Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109-1024, USA., Huang MW; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA 98195, USA., Jerome KR; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA 98195, USA.; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle WA 98109-1024, USA., Kiem HP; Stem Cell and Gene Therapy Program, Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109-1024, USA.; Department of Medicine, University of Washington, Seattle, WA 98195, USA., Humbert O; Stem Cell and Gene Therapy Program, Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109-1024, USA.
Source: Molecular therapy. Methods & clinical development [Mol Ther Methods Clin Dev] 2021 Oct 28; Vol. 23, pp. 507-523. Date of Electronic Publication: 2021 Oct 28 (Print Publication: 2021).
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101624857 Publication Model: eCollection Cited Medium: Print ISSN: 2329-0501 (Print) Linking ISSN: 23290501 NLM ISO Abbreviation: Mol Ther Methods Clin Dev Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Multiplex CRISPR/Cas9 genome editing in hematopoietic stem cells for fetal hemoglobin reinduction generates chromosomal translocations.
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  Data: <searchLink fieldCode="AU" term="%22Samuelson+C%22">Samuelson C</searchLink>; Stem Cell and Gene Therapy Program, Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109-1024, USA.<br /><searchLink fieldCode="AU" term="%22Radtke+S%22">Radtke S</searchLink>; Stem Cell and Gene Therapy Program, Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109-1024, USA.<br /><searchLink fieldCode="AU" term="%22Zhu+H%22">Zhu H</searchLink>; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA 98195, USA.<br /><searchLink fieldCode="AU" term="%22Llewellyn+M%22">Llewellyn M</searchLink>; Stem Cell and Gene Therapy Program, Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109-1024, USA.<br /><searchLink fieldCode="AU" term="%22Fields+E%22">Fields E</searchLink>; Stem Cell and Gene Therapy Program, Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109-1024, USA.<br /><searchLink fieldCode="AU" term="%22Cook+S%22">Cook S</searchLink>; Stem Cell and Gene Therapy Program, Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109-1024, USA.<br /><searchLink fieldCode="AU" term="%22Huang+MW%22">Huang MW</searchLink>; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA 98195, USA.<br /><searchLink fieldCode="AU" term="%22Jerome+KR%22">Jerome KR</searchLink>; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA 98195, USA.; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle WA 98109-1024, USA.<br /><searchLink fieldCode="AU" term="%22Kiem+HP%22">Kiem HP</searchLink>; Stem Cell and Gene Therapy Program, Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109-1024, USA.; Department of Medicine, University of Washington, Seattle, WA 98195, USA.<br /><searchLink fieldCode="AU" term="%22Humbert+O%22">Humbert O</searchLink>; Stem Cell and Gene Therapy Program, Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109-1024, USA.
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  Data: <searchLink fieldCode="JN" term="%22101624857%22">Molecular therapy. Methods & clinical development</searchLink> [Mol Ther Methods Clin Dev] 2021 Oct 28; Vol. 23, pp. 507-523. <i>Date of Electronic Publication: </i>2021 Oct 28 (<i>Print Publication: </i>2021).
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Cell+Press%22">Cell Press </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101624857 <i>Publication Model: </i>eCollection <i>Cited Medium: </i>Print <i>ISSN: </i>2329-0501 (Print) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2223290501%22">23290501 </searchLink><i>NLM ISO Abbreviation: </i>Mol Ther Methods Clin Dev <i>Subsets: </i>PubMed not MEDLINE
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        Value: 10.1016/j.omtm.2021.10.008
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              Text: 2021 Oct 28
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