View in EDS

Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancers.

Saved in:
Bibliographic Details
Title: Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancers.
Authors: Ito T; Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.; Scorpion Therapeutics, Boston, MA, USA., Young MJ; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Li R; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Jain S; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Wernitznig A; Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Boehringer Ingelheim RCV GmbH & Co KG, Vienna, Austria., Krill-Burger JM; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Lemke CT; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Monducci D; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Rodriguez DJ; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Chang L; Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Harvard Medical School, Boston, MA, USA., Dutta S; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Pal D; Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Paolella BR; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Rothberg MV; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Root DE; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Johannessen CM; Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Oncology, Novartis Institutes for BioMedical Research, Cambridge, MA, USA., Parida L; IBM Research, T.J. Watson Research Center, Yorktown Heights, NY, USA., Getz G; Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Harvard Medical School, Boston, MA, USA.; Cancer Center and Department of Pathology, Massachusetts General Hospital, Boston, MA, USA., Vazquez F; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Doench JG; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Zamanighomi M; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Sellers WR; Broad Institute of Harvard and MIT, Cambridge, MA, USA. wsellers@broadinstitute.org.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. wsellers@broadinstitute.org.; Harvard Medical School, Boston, MA, USA. wsellers@broadinstitute.org.
Source: Nature genetics [Nat Genet] 2021 Dec; Vol. 53 (12), pp. 1664-1672. Date of Electronic Publication: 2021 Dec 02.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
Journal Info: Publisher: Nature Pub. Co Country of Publication: United States NLM ID: 9216904 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-1718 (Electronic) Linking ISSN: 10614036 NLM ISO Abbreviation: Nat Genet Subsets: MEDLINE
Database: MEDLINE Ultimate
FullText Text:
  Availability: 0
Header DbId: mdl
DbLabel: MEDLINE Ultimate
An: 34857952
AccessLevel: 2
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancers.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22Ito+T%22">Ito T</searchLink>; Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.; Scorpion Therapeutics, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Young+MJ%22">Young MJ</searchLink>; Broad Institute of Harvard and MIT, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Li+R%22">Li R</searchLink>; Broad Institute of Harvard and MIT, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Jain+S%22">Jain S</searchLink>; Broad Institute of Harvard and MIT, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Wernitznig+A%22">Wernitznig A</searchLink>; Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Boehringer Ingelheim RCV GmbH & Co KG, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Krill-Burger+JM%22">Krill-Burger JM</searchLink>; Broad Institute of Harvard and MIT, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Lemke+CT%22">Lemke CT</searchLink>; Broad Institute of Harvard and MIT, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Monducci+D%22">Monducci D</searchLink>; Broad Institute of Harvard and MIT, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Rodriguez+DJ%22">Rodriguez DJ</searchLink>; Broad Institute of Harvard and MIT, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Chang+L%22">Chang L</searchLink>; Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Dutta+S%22">Dutta S</searchLink>; Broad Institute of Harvard and MIT, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Pal+D%22">Pal D</searchLink>; Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Paolella+BR%22">Paolella BR</searchLink>; Broad Institute of Harvard and MIT, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Rothberg+MV%22">Rothberg MV</searchLink>; Broad Institute of Harvard and MIT, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Root+DE%22">Root DE</searchLink>; Broad Institute of Harvard and MIT, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Johannessen+CM%22">Johannessen CM</searchLink>; Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Oncology, Novartis Institutes for BioMedical Research, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Parida+L%22">Parida L</searchLink>; IBM Research, T.J. Watson Research Center, Yorktown Heights, NY, USA.<br /><searchLink fieldCode="AU" term="%22Getz+G%22">Getz G</searchLink>; Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Harvard Medical School, Boston, MA, USA.; Cancer Center and Department of Pathology, Massachusetts General Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Vazquez+F%22">Vazquez F</searchLink>; Broad Institute of Harvard and MIT, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Doench+JG%22">Doench JG</searchLink>; Broad Institute of Harvard and MIT, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Zamanighomi+M%22">Zamanighomi M</searchLink>; Broad Institute of Harvard and MIT, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Sellers+WR%22">Sellers WR</searchLink>; Broad Institute of Harvard and MIT, Cambridge, MA, USA. wsellers@broadinstitute.org.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. wsellers@broadinstitute.org.; Harvard Medical School, Boston, MA, USA. wsellers@broadinstitute.org.
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%229216904%22">Nature genetics</searchLink> [Nat Genet] 2021 Dec; Vol. 53 (12), pp. 1664-1672. <i>Date of Electronic Publication: </i>2021 Dec 02.
– Name: TypePub
  Label: Publication Type
  Group: TypPub
  Data: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
– Name: TitleSource
  Label: Journal Info
  Group: Src
  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Pub%2E+Co%22">Nature Pub. Co </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>9216904 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1546-1718 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2210614036%22">10614036 </searchLink><i>NLM ISO Abbreviation: </i>Nat Genet <i>Subsets: </i>MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=34857952
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1038/s41588-021-00967-z
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        StartPage: 1664
    Titles:
      – TitleFull: Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancers.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Ito T
      – PersonEntity:
          Name:
            NameFull: Young MJ
      – PersonEntity:
          Name:
            NameFull: Li R
      – PersonEntity:
          Name:
            NameFull: Jain S
      – PersonEntity:
          Name:
            NameFull: Wernitznig A
      – PersonEntity:
          Name:
            NameFull: Krill-Burger JM
      – PersonEntity:
          Name:
            NameFull: Lemke CT
      – PersonEntity:
          Name:
            NameFull: Monducci D
      – PersonEntity:
          Name:
            NameFull: Rodriguez DJ
      – PersonEntity:
          Name:
            NameFull: Chang L
      – PersonEntity:
          Name:
            NameFull: Dutta S
      – PersonEntity:
          Name:
            NameFull: Pal D
      – PersonEntity:
          Name:
            NameFull: Paolella BR
      – PersonEntity:
          Name:
            NameFull: Rothberg MV
      – PersonEntity:
          Name:
            NameFull: Root DE
      – PersonEntity:
          Name:
            NameFull: Johannessen CM
      – PersonEntity:
          Name:
            NameFull: Parida L
      – PersonEntity:
          Name:
            NameFull: Getz G
      – PersonEntity:
          Name:
            NameFull: Vazquez F
      – PersonEntity:
          Name:
            NameFull: Doench JG
      – PersonEntity:
          Name:
            NameFull: Zamanighomi M
      – PersonEntity:
          Name:
            NameFull: Sellers WR
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 12
              Text: 2021 Dec
              Type: published
              Y: 2021
          Identifiers:
            – Type: issn-electronic
              Value: 1546-1718
          Numbering:
            – Type: volume
              Value: 53
            – Type: issue
              Value: 12
          Titles:
            – TitleFull: Nature genetics
              Type: main
ResultId 1