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Implanted pluripotent stem-cell-derived pancreatic endoderm cells secrete glucose-responsive C-peptide in patients with type 1 diabetes.

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Title: Implanted pluripotent stem-cell-derived pancreatic endoderm cells secrete glucose-responsive C-peptide in patients with type 1 diabetes.
Authors: Ramzy A; Laboratory of Molecular and Cellular Medicine, Department of Cellular and Physiological Sciences, Life Sciences Institute, University of British Columbia, Vancouver, BC V6T 1Z3, Canada., Thompson DM; Division of Endocrinology, Department of Medicine, University of British Columbia, Vancouver, BC V6T 1Z3, Canada., Ward-Hartstonge KA; Department of Surgery, University of British Columbia, Vancouver, BC V6T 1Z3, Canada; BC Children's Hospital Research Institute (BCCHRI), Vancouver, BC V5Z 4H4, Canada., Ivison S; Department of Surgery, University of British Columbia, Vancouver, BC V6T 1Z3, Canada; BC Children's Hospital Research Institute (BCCHRI), Vancouver, BC V5Z 4H4, Canada., Cook L; Department of Surgery, University of British Columbia, Vancouver, BC V6T 1Z3, Canada; BC Children's Hospital Research Institute (BCCHRI), Vancouver, BC V5Z 4H4, Canada., Garcia RV; Department of Surgery, University of British Columbia, Vancouver, BC V6T 1Z3, Canada; BC Children's Hospital Research Institute (BCCHRI), Vancouver, BC V5Z 4H4, Canada., Loyal J; Division of Endocrinology, Department of Medicine, University of British Columbia, Vancouver, BC V6T 1Z3, Canada., Kim PTW; Department of Surgery, University of British Columbia, Vancouver, BC V6T 1Z3, Canada., Warnock GL; Department of Surgery, University of British Columbia, Vancouver, BC V6T 1Z3, Canada., Levings MK; Department of Surgery, University of British Columbia, Vancouver, BC V6T 1Z3, Canada; BC Children's Hospital Research Institute (BCCHRI), Vancouver, BC V5Z 4H4, Canada; School of Biomedical Engineering, University of British Columbia, Vancouver, BC V6T 1Z3, Canada., Kieffer TJ; Laboratory of Molecular and Cellular Medicine, Department of Cellular and Physiological Sciences, Life Sciences Institute, University of British Columbia, Vancouver, BC V6T 1Z3, Canada; Department of Surgery, University of British Columbia, Vancouver, BC V6T 1Z3, Canada; School of Biomedical Engineering, University of British Columbia, Vancouver, BC V6T 1Z3, Canada. Electronic address: tim.kieffer@ubc.ca.
Source: Cell stem cell [Cell Stem Cell] 2021 Dec 02; Vol. 28 (12), pp. 2047-2061.e5.
Publication Type: Clinical Trial, Phase I; Clinical Trial, Phase II; Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101311472 Publication Model: Print Cited Medium: Internet ISSN: 1875-9777 (Electronic) Linking ISSN: 18759777 NLM ISO Abbreviation: Cell Stem Cell Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Implanted pluripotent stem-cell-derived pancreatic endoderm cells secrete glucose-responsive C-peptide in patients with type 1 diabetes.
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  Data: <searchLink fieldCode="AU" term="%22Ramzy+A%22">Ramzy A</searchLink>; Laboratory of Molecular and Cellular Medicine, Department of Cellular and Physiological Sciences, Life Sciences Institute, University of British Columbia, Vancouver, BC V6T 1Z3, Canada.<br /><searchLink fieldCode="AU" term="%22Thompson+DM%22">Thompson DM</searchLink>; Division of Endocrinology, Department of Medicine, University of British Columbia, Vancouver, BC V6T 1Z3, Canada.<br /><searchLink fieldCode="AU" term="%22Ward-Hartstonge+KA%22">Ward-Hartstonge KA</searchLink>; Department of Surgery, University of British Columbia, Vancouver, BC V6T 1Z3, Canada; BC Children's Hospital Research Institute (BCCHRI), Vancouver, BC V5Z 4H4, Canada.<br /><searchLink fieldCode="AU" term="%22Ivison+S%22">Ivison S</searchLink>; Department of Surgery, University of British Columbia, Vancouver, BC V6T 1Z3, Canada; BC Children's Hospital Research Institute (BCCHRI), Vancouver, BC V5Z 4H4, Canada.<br /><searchLink fieldCode="AU" term="%22Cook+L%22">Cook L</searchLink>; Department of Surgery, University of British Columbia, Vancouver, BC V6T 1Z3, Canada; BC Children's Hospital Research Institute (BCCHRI), Vancouver, BC V5Z 4H4, Canada.<br /><searchLink fieldCode="AU" term="%22Garcia+RV%22">Garcia RV</searchLink>; Department of Surgery, University of British Columbia, Vancouver, BC V6T 1Z3, Canada; BC Children's Hospital Research Institute (BCCHRI), Vancouver, BC V5Z 4H4, Canada.<br /><searchLink fieldCode="AU" term="%22Loyal+J%22">Loyal J</searchLink>; Division of Endocrinology, Department of Medicine, University of British Columbia, Vancouver, BC V6T 1Z3, Canada.<br /><searchLink fieldCode="AU" term="%22Kim+PTW%22">Kim PTW</searchLink>; Department of Surgery, University of British Columbia, Vancouver, BC V6T 1Z3, Canada.<br /><searchLink fieldCode="AU" term="%22Warnock+GL%22">Warnock GL</searchLink>; Department of Surgery, University of British Columbia, Vancouver, BC V6T 1Z3, Canada.<br /><searchLink fieldCode="AU" term="%22Levings+MK%22">Levings MK</searchLink>; Department of Surgery, University of British Columbia, Vancouver, BC V6T 1Z3, Canada; BC Children's Hospital Research Institute (BCCHRI), Vancouver, BC V5Z 4H4, Canada; School of Biomedical Engineering, University of British Columbia, Vancouver, BC V6T 1Z3, Canada.<br /><searchLink fieldCode="AU" term="%22Kieffer+TJ%22">Kieffer TJ</searchLink>; Laboratory of Molecular and Cellular Medicine, Department of Cellular and Physiological Sciences, Life Sciences Institute, University of British Columbia, Vancouver, BC V6T 1Z3, Canada; Department of Surgery, University of British Columbia, Vancouver, BC V6T 1Z3, Canada; School of Biomedical Engineering, University of British Columbia, Vancouver, BC V6T 1Z3, Canada. Electronic address: tim.kieffer@ubc.ca.
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        Value: 10.1016/j.stem.2021.10.003
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              Text: 2021 Dec 02
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