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Current Practices, Gap Analysis, and Proposed Workflows for PBPK Modeling of Cytochrome P450 Induction: An Industry Perspective.

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Title: Current Practices, Gap Analysis, and Proposed Workflows for PBPK Modeling of Cytochrome P450 Induction: An Industry Perspective.
Authors: Hariparsad N; DMPK, Research and Early Development, Oncology R&D, AstraZeneca, Boston, Massachusetts, USA., Ramsden D; Takeda Development Center Americas, Inc., Cambridge, Massachusetts, USA., Taskar K; Drug Metabolism and Pharmacokinetics, IVIVT, GlaxoSmithKline, Stevenage, UK., Badée J; PK Sciences, Novartis Institutes for Biomedical Research, Basel, Switzerland., Venkatakrishnan K; EMD Serono Research & Development Institute, Inc, Billerica, Massachusetts, USA.; Merck KGaA, Darmstadt, Germany., Reddy MB; Department of Clinical Pharmacology, Oncology, Pfizer, Boulder, Colorado, USA., Cabalu T; Merck & Co., Inc., Kenilworth, New Jersey, USA., Mukherjee D; Clinical Pharmacology & Pharmacometrics, AbbVie, Inc., North Chicago, Illinois, USA., Rehmel J; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana, USA., Bolleddula J; EMD Serono Research & Development Institute, Inc, Billerica, Massachusetts, USA.; Merck KGaA, Darmstadt, Germany., Emami Riedmaier A; Bristol Meyers Squibb, Princeton, New Jersey, USA., Prakash C; Agios Pharmaceuticals, Cambridge, Massachusetts, USA., Chanteux H; UCB Biopharma, QP-DMPK, Brussels, Belgium., Mao J; Department of Drug Metabolism and Pharmacokinetics, Genentech, A Member of the Roche Group, South San Francisco, California, USA., Umehara K; Pharmaceutical Sciences, Roche Pharma Research & Early Development, Roche Innovation Center Basel, Basel, Switzerland., Shah K; Drug Metabolism and Pharmacokinetics, Vertex Pharmaceuticals Incorporated, Boston, Massachusetts, USA., De Zwart L; DMPK, Janssen Research and Development, Beerse, Belgium., Dowty M; Department of Pharmacokinetics, Dynamic, and Metabolism, Pfizer, Cambridge, Massachusetts, USA., Kotsuma M; Quantitative Clinical Pharmacology, Daiichi-Sankyo, Inc., New Jersey, USA., Li M; Pharmacokinetics, Dynamics and Metabolism, Sanofi, Bridgewater, New Jersey, USA., Pilla Reddy V; Clinical Pharmacology and Pharmacometrics, Biopharmaceuticals R&D, AstraZeneca, Cambridge, UK., McGinnity DF; DMPK, Research and Early Development, Oncology R&D, AstraZeneca, Cambridge, UK., Parrott N; Pharmaceutical Sciences, Roche Pharma Research & Early Development, Roche Innovation Center Basel, Basel, Switzerland.
Source: Clinical pharmacology and therapeutics [Clin Pharmacol Ther] 2022 Oct; Vol. 112 (4), pp. 770-781. Date of Electronic Publication: 2021 Dec 24.
Publication Type: Journal Article
Journal Info: Publisher: Wiley Country of Publication: United States NLM ID: 0372741 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-6535 (Electronic) Linking ISSN: 00099236 NLM ISO Abbreviation: Clin Pharmacol Ther Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Hariparsad+N%22">Hariparsad N</searchLink>; DMPK, Research and Early Development, Oncology R&D, AstraZeneca, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Ramsden+D%22">Ramsden D</searchLink>; Takeda Development Center Americas, Inc., Cambridge, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Taskar+K%22">Taskar K</searchLink>; Drug Metabolism and Pharmacokinetics, IVIVT, GlaxoSmithKline, Stevenage, UK.<br /><searchLink fieldCode="AU" term="%22Badée+J%22">Badée J</searchLink>; PK Sciences, Novartis Institutes for Biomedical Research, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Venkatakrishnan+K%22">Venkatakrishnan K</searchLink>; EMD Serono Research & Development Institute, Inc, Billerica, Massachusetts, USA.; Merck KGaA, Darmstadt, Germany.<br /><searchLink fieldCode="AU" term="%22Reddy+MB%22">Reddy MB</searchLink>; Department of Clinical Pharmacology, Oncology, Pfizer, Boulder, Colorado, USA.<br /><searchLink fieldCode="AU" term="%22Cabalu+T%22">Cabalu T</searchLink>; Merck & Co., Inc., Kenilworth, New Jersey, USA.<br /><searchLink fieldCode="AU" term="%22Mukherjee+D%22">Mukherjee D</searchLink>; Clinical Pharmacology & Pharmacometrics, AbbVie, Inc., North Chicago, Illinois, USA.<br /><searchLink fieldCode="AU" term="%22Rehmel+J%22">Rehmel J</searchLink>; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana, USA.<br /><searchLink fieldCode="AU" term="%22Bolleddula+J%22">Bolleddula J</searchLink>; EMD Serono Research & Development Institute, Inc, Billerica, Massachusetts, USA.; Merck KGaA, Darmstadt, Germany.<br /><searchLink fieldCode="AU" term="%22Emami+Riedmaier+A%22">Emami Riedmaier A</searchLink>; Bristol Meyers Squibb, Princeton, New Jersey, USA.<br /><searchLink fieldCode="AU" term="%22Prakash+C%22">Prakash C</searchLink>; Agios Pharmaceuticals, Cambridge, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Chanteux+H%22">Chanteux H</searchLink>; UCB Biopharma, QP-DMPK, Brussels, Belgium.<br /><searchLink fieldCode="AU" term="%22Mao+J%22">Mao J</searchLink>; Department of Drug Metabolism and Pharmacokinetics, Genentech, A Member of the Roche Group, South San Francisco, California, USA.<br /><searchLink fieldCode="AU" term="%22Umehara+K%22">Umehara K</searchLink>; Pharmaceutical Sciences, Roche Pharma Research & Early Development, Roche Innovation Center Basel, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Shah+K%22">Shah K</searchLink>; Drug Metabolism and Pharmacokinetics, Vertex Pharmaceuticals Incorporated, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22De+Zwart+L%22">De Zwart L</searchLink>; DMPK, Janssen Research and Development, Beerse, Belgium.<br /><searchLink fieldCode="AU" term="%22Dowty+M%22">Dowty M</searchLink>; Department of Pharmacokinetics, Dynamic, and Metabolism, Pfizer, Cambridge, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Kotsuma+M%22">Kotsuma M</searchLink>; Quantitative Clinical Pharmacology, Daiichi-Sankyo, Inc., New Jersey, USA.<br /><searchLink fieldCode="AU" term="%22Li+M%22">Li M</searchLink>; Pharmacokinetics, Dynamics and Metabolism, Sanofi, Bridgewater, New Jersey, USA.<br /><searchLink fieldCode="AU" term="%22Pilla+Reddy+V%22">Pilla Reddy V</searchLink>; Clinical Pharmacology and Pharmacometrics, Biopharmaceuticals R&D, AstraZeneca, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22McGinnity+DF%22">McGinnity DF</searchLink>; DMPK, Research and Early Development, Oncology R&D, AstraZeneca, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Parrott+N%22">Parrott N</searchLink>; Pharmaceutical Sciences, Roche Pharma Research & Early Development, Roche Innovation Center Basel, Basel, Switzerland.
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