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Integration of GWAS and brain transcriptomic analyses in a multiethnic sample of 35,245 older adults identifies DCDC2 gene as predictor of episodic memory maintenance.

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Title: Integration of GWAS and brain transcriptomic analyses in a multiethnic sample of 35,245 older adults identifies DCDC2 gene as predictor of episodic memory maintenance.
Authors: Gao Y; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York, USA., Felsky D; Krembil Centre for Neuroinformatics, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.; Department of Psychiatry & Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada., Reyes-Dumeyer D; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York, USA.; G.H. Sergievsky Center, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York, USA.; Department of Neurology, Vagelos College of Physicians and Surgeons, New York-Presbyterian Hospital, Columbia University Medical Center, New York, New York, USA., Sariya S; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York, USA., Rentería MA; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York, USA.; Department of Neurology, Vagelos College of Physicians and Surgeons, New York-Presbyterian Hospital, Columbia University Medical Center, New York, New York, USA., Ma Y; Center for Translational & Computational Neuroimmunology, Department of Neurology, Columbia University Irving Medical Center, New York, New York, USA., Klein HU; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York, USA.; Center for Translational & Computational Neuroimmunology, Department of Neurology, Columbia University Irving Medical Center, New York, New York, USA., Cosentino S; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York, USA.; G.H. Sergievsky Center, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York, USA.; Department of Neurology, Vagelos College of Physicians and Surgeons, New York-Presbyterian Hospital, Columbia University Medical Center, New York, New York, USA., De Jager PL; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York, USA.; Center for Translational & Computational Neuroimmunology, Department of Neurology, Columbia University Irving Medical Center, New York, New York, USA.; Cell Circuits Program, Broad Institute, Cambridge, Massachusetts, USA., Bennett DA; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, USA.; Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois, USA., Brickman AM; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York, USA.; G.H. Sergievsky Center, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York, USA.; Department of Neurology, Vagelos College of Physicians and Surgeons, New York-Presbyterian Hospital, Columbia University Medical Center, New York, New York, USA., Schellenberg GD; Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Mayeux R; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York, USA.; G.H. Sergievsky Center, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York, USA.; Department of Neurology, Vagelos College of Physicians and Surgeons, New York-Presbyterian Hospital, Columbia University Medical Center, New York, New York, USA., Barral S; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York, USA.; G.H. Sergievsky Center, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York, USA.; Department of Neurology, Vagelos College of Physicians and Surgeons, New York-Presbyterian Hospital, Columbia University Medical Center, New York, New York, USA.
Corporate Authors: CHAP, UKBB, ADNI, ROSMAP, LLFS, NIA-LOAD and ADGC consortia; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York, USA.
Source: Alzheimer's & dementia : the journal of the Alzheimer's Association [Alzheimers Dement] 2022 Oct; Vol. 18 (10), pp. 1797-1811. Date of Electronic Publication: 2021 Dec 07.
Publication Type: Meta-Analysis; Journal Article; Research Support, N.I.H., Extramural
Journal Info: Publisher: John Wiley & Sons, Ltd Country of Publication: United States NLM ID: 101231978 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1552-5279 (Electronic) Linking ISSN: 15525260 NLM ISO Abbreviation: Alzheimers Dement Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Integration of GWAS and brain transcriptomic analyses in a multiethnic sample of 35,245 older adults identifies DCDC2 gene as predictor of episodic memory maintenance.
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Sergievsky Center, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York, USA.; Department of Neurology, Vagelos College of Physicians and Surgeons, New York-Presbyterian Hospital, Columbia University Medical Center, New York, New York, USA.<br /><searchLink fieldCode="AU" term="%22Sariya+S%22">Sariya S</searchLink>; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York, USA.<br /><searchLink fieldCode="AU" term="%22Rentería+MA%22">Rentería MA</searchLink>; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York, USA.; Department of Neurology, Vagelos College of Physicians and Surgeons, New York-Presbyterian Hospital, Columbia University Medical Center, New York, New York, USA.<br /><searchLink fieldCode="AU" term="%22Ma+Y%22">Ma Y</searchLink>; Center for Translational & Computational Neuroimmunology, Department of Neurology, Columbia University Irving Medical Center, New York, New York, USA.<br /><searchLink fieldCode="AU" term="%22Klein+HU%22">Klein HU</searchLink>; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York, USA.; Center for Translational & Computational Neuroimmunology, Department of Neurology, Columbia University Irving Medical Center, New York, New York, USA.<br /><searchLink fieldCode="AU" term="%22Cosentino+S%22">Cosentino S</searchLink>; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York, USA.; G.H. Sergievsky Center, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York, USA.; Department of Neurology, Vagelos College of Physicians and Surgeons, New York-Presbyterian Hospital, Columbia University Medical Center, New York, New York, USA.<br /><searchLink fieldCode="AU" term="%22De+Jager+PL%22">De Jager PL</searchLink>; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York, USA.; Center for Translational & Computational Neuroimmunology, Department of Neurology, Columbia University Irving Medical Center, New York, New York, USA.; Cell Circuits Program, Broad Institute, Cambridge, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Bennett+DA%22">Bennett DA</searchLink>; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, USA.; Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois, USA.<br /><searchLink fieldCode="AU" term="%22Brickman+AM%22">Brickman AM</searchLink>; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York, USA.; G.H. Sergievsky Center, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York, USA.; Department of Neurology, Vagelos College of Physicians and Surgeons, New York-Presbyterian Hospital, Columbia University Medical Center, New York, New York, USA.<br /><searchLink fieldCode="AU" term="%22Schellenberg+GD%22">Schellenberg GD</searchLink>; Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Mayeux+R%22">Mayeux R</searchLink>; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York, USA.; G.H. Sergievsky Center, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York, USA.; Department of Neurology, Vagelos College of Physicians and Surgeons, New York-Presbyterian Hospital, Columbia University Medical Center, New York, New York, USA.<br /><searchLink fieldCode="AU" term="%22Barral+S%22">Barral S</searchLink>; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York, USA.; G.H. Sergievsky Center, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York, USA.; Department of Neurology, Vagelos College of Physicians and Surgeons, New York-Presbyterian Hospital, Columbia University Medical Center, New York, New York, USA.
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  Data: <searchLink fieldCode="JN" term="%22101231978%22">Alzheimer's & dementia : the journal of the Alzheimer's Association</searchLink> [Alzheimers Dement] 2022 Oct; Vol. 18 (10), pp. 1797-1811. <i>Date of Electronic Publication: </i>2021 Dec 07.
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