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The protective gene dose effect of the APOE ε2 allele on gray matter volume in cognitively unimpaired individuals.

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Title: The protective gene dose effect of the APOE ε2 allele on gray matter volume in cognitively unimpaired individuals.
Authors: Salvadó G; Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation, Barcelona, Spain.; IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain., Ferreira D; Division of Clinical Geriatrics, Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden.; Department of Radiology, Mayo Clinic, Rochester, Minnesota, USA., Operto G; Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation, Barcelona, Spain.; IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain.; CIBER Fragilidad y Envejecimiento Saludable (CIBERFES), Madrid, Spain., Cumplido-Mayoral I; Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation, Barcelona, Spain.; Universitat Pompeu Fabra, Barcelona, Spain., Arenaza-Urquijo EM; Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation, Barcelona, Spain.; IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain.; CIBER Fragilidad y Envejecimiento Saludable (CIBERFES), Madrid, Spain., Cacciaglia R; Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation, Barcelona, Spain.; IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain.; CIBER Fragilidad y Envejecimiento Saludable (CIBERFES), Madrid, Spain., Falcon C; Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation, Barcelona, Spain.; IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain.; Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Madrid, Spain., Vilor-Tejedor N; Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation, Barcelona, Spain.; Universitat Pompeu Fabra, Barcelona, Spain.; Centre for Genomic Regulation (CRG), The Barcelona Institute for Science and Technology, Barcelona, Spain.; Department of Clinical Genetics, ERASMUS MC, Rotterdam, the Netherlands., Minguillon C; Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation, Barcelona, Spain.; IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain.; CIBER Fragilidad y Envejecimiento Saludable (CIBERFES), Madrid, Spain., Groot C; Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands., van der Flier WM; Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands.; Department of Epidemiology & Biostatistics, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands., Barkhof F; Department of Radiology and Nuclear Medicine, VU Medical Center, Neuroscience Campus Amsterdam, Amsterdam, the Netherlands.; Institutes of Neurology & Healthcare Engineering, University College London, London, UK., Scheltens P; Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands., Ossenkoppele R; Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands.; Clinical Memory Research Unit, Lund University, Lund, Sweden., Kern S; Neuropsychiatric Epidemiology Unit, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy, Centre for Ageing and Health (AgeCap) at the University of Gothenburg, Gothenburg, Sweden., Zettergren A; Neuropsychiatric Epidemiology Unit, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy, Centre for Ageing and Health (AgeCap) at the University of Gothenburg, Gothenburg, Sweden., Skoog I; Neuropsychiatric Epidemiology Unit, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy, Centre for Ageing and Health (AgeCap) at the University of Gothenburg, Gothenburg, Sweden., Hort J; International Clinical Research Centre, St. Anne's University Hospital Brno, Brno, Czech Republic.; Memory Clinic, Department of Neurology, Charles University, 2nd Faculty of Medicine and Motol University Hospital, Prague, Czech Republic., Stomrud E; Department of Clinical Sciences, Clinical Memory Research Unit, Lund University, Lund, Sweden.; Memory Clinic, Skåne University Hospital, Malmö, Sweden., van Westen D; Diagnostic Radiology, Institution for Clinical Sciences, Lund University, Lund, Sweden.; Image and Function, Skåne University Hospital, Lund, Sweden., Hansson O; Department of Clinical Sciences, Clinical Memory Research Unit, Lund University, Lund, Sweden.; Memory Clinic, Skåne University Hospital, Malmö, Sweden., Molinuevo JL; Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation, Barcelona, Spain., Wahlund LO; Division of Clinical Geriatrics, Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden., Westman E; Division of Clinical Geriatrics, Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden.; Department of Neuroimaging, Centre for Neuroimaging Sciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK., Gispert JD; Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation, Barcelona, Spain.; IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain.; Universitat Pompeu Fabra, Barcelona, Spain.; Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Madrid, Spain.
Corporate Authors: ALFA study†, BioFINDER, ADNI
Source: Alzheimer's & dementia : the journal of the Alzheimer's Association [Alzheimers Dement] 2022 Jul; Vol. 18 (7), pp. 1383-1395. Date of Electronic Publication: 2021 Dec 08.
Publication Type: Journal Article; Multicenter Study
Journal Info: Publisher: John Wiley & Sons, Ltd Country of Publication: United States NLM ID: 101231978 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1552-5279 (Electronic) Linking ISSN: 15525260 NLM ISO Abbreviation: Alzheimers Dement Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: The protective gene dose effect of the APOE ε2 allele on gray matter volume in cognitively unimpaired individuals.
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  Data: <searchLink fieldCode="AU" term="%22Salvadó+G%22">Salvadó G</searchLink>; Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation, Barcelona, Spain.; IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Ferreira+D%22">Ferreira D</searchLink>; Division of Clinical Geriatrics, Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden.; Department of Radiology, Mayo Clinic, Rochester, Minnesota, USA.<br /><searchLink fieldCode="AU" term="%22Operto+G%22">Operto G</searchLink>; Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation, Barcelona, Spain.; IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain.; CIBER Fragilidad y Envejecimiento Saludable (CIBERFES), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Cumplido-Mayoral+I%22">Cumplido-Mayoral I</searchLink>; Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation, Barcelona, Spain.; Universitat Pompeu Fabra, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Arenaza-Urquijo+EM%22">Arenaza-Urquijo EM</searchLink>; Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation, Barcelona, Spain.; IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain.; CIBER Fragilidad y Envejecimiento Saludable (CIBERFES), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Cacciaglia+R%22">Cacciaglia R</searchLink>; Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation, Barcelona, Spain.; IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain.; CIBER Fragilidad y Envejecimiento Saludable (CIBERFES), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Falcon+C%22">Falcon C</searchLink>; Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation, Barcelona, Spain.; IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain.; Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Vilor-Tejedor+N%22">Vilor-Tejedor N</searchLink>; Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation, Barcelona, Spain.; Universitat Pompeu Fabra, Barcelona, Spain.; Centre for Genomic Regulation (CRG), The Barcelona Institute for Science and Technology, Barcelona, Spain.; Department of Clinical Genetics, ERASMUS MC, Rotterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Minguillon+C%22">Minguillon C</searchLink>; Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation, Barcelona, Spain.; IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain.; CIBER Fragilidad y Envejecimiento Saludable (CIBERFES), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Groot+C%22">Groot C</searchLink>; Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22van+der+Flier+WM%22">van der Flier WM</searchLink>; Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands.; Department of Epidemiology & Biostatistics, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Barkhof+F%22">Barkhof F</searchLink>; Department of Radiology and Nuclear Medicine, VU Medical Center, Neuroscience Campus Amsterdam, Amsterdam, the Netherlands.; Institutes of Neurology & Healthcare Engineering, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Scheltens+P%22">Scheltens P</searchLink>; Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Ossenkoppele+R%22">Ossenkoppele R</searchLink>; Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands.; Clinical Memory Research Unit, Lund University, Lund, Sweden.<br /><searchLink fieldCode="AU" term="%22Kern+S%22">Kern S</searchLink>; Neuropsychiatric Epidemiology Unit, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy, Centre for Ageing and Health (AgeCap) at the University of Gothenburg, Gothenburg, Sweden.<br /><searchLink fieldCode="AU" term="%22Zettergren+A%22">Zettergren A</searchLink>; Neuropsychiatric Epidemiology Unit, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy, Centre for Ageing and Health (AgeCap) at the University of Gothenburg, Gothenburg, Sweden.<br /><searchLink fieldCode="AU" term="%22Skoog+I%22">Skoog I</searchLink>; Neuropsychiatric Epidemiology Unit, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy, Centre for Ageing and Health (AgeCap) at the University of Gothenburg, Gothenburg, Sweden.<br /><searchLink fieldCode="AU" term="%22Hort+J%22">Hort J</searchLink>; International Clinical Research Centre, St. Anne's University Hospital Brno, Brno, Czech Republic.; Memory Clinic, Department of Neurology, Charles University, 2nd Faculty of Medicine and Motol University Hospital, Prague, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Stomrud+E%22">Stomrud E</searchLink>; Department of Clinical Sciences, Clinical Memory Research Unit, Lund University, Lund, Sweden.; Memory Clinic, Skåne University Hospital, Malmö, Sweden.<br /><searchLink fieldCode="AU" term="%22van+Westen+D%22">van Westen D</searchLink>; Diagnostic Radiology, Institution for Clinical Sciences, Lund University, Lund, Sweden.; Image and Function, Skåne University Hospital, Lund, Sweden.<br /><searchLink fieldCode="AU" term="%22Hansson+O%22">Hansson O</searchLink>; Department of Clinical Sciences, Clinical Memory Research Unit, Lund University, Lund, Sweden.; Memory Clinic, Skåne University Hospital, Malmö, Sweden.<br /><searchLink fieldCode="AU" term="%22Molinuevo+JL%22">Molinuevo JL</searchLink>; Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Wahlund+LO%22">Wahlund LO</searchLink>; Division of Clinical Geriatrics, Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Westman+E%22">Westman E</searchLink>; Division of Clinical Geriatrics, Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden.; Department of Neuroimaging, Centre for Neuroimaging Sciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Gispert+JD%22">Gispert JD</searchLink>; Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation, Barcelona, Spain.; IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain.; Universitat Pompeu Fabra, Barcelona, Spain.; Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Madrid, Spain.
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