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Mitochondrial DNA heteroplasmy is modulated during oocyte development propagating mutation transmission.

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Title: Mitochondrial DNA heteroplasmy is modulated during oocyte development propagating mutation transmission.
Authors: Zhang H; Department of Clinical Neurosciences, School of Clinical Medicine, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK.; Medical Research Council Mitochondrial Biology Unit, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK., Esposito M; EPSRC Centre for the Mathematics of Precision Healthcare, Department of Mathematics, Imperial College, London, UK.; Leverhulme Centre for Cellular Bionics, Imperial College, London, UK., Pezet MG; Department of Clinical Neurosciences, School of Clinical Medicine, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK.; Medical Research Council Mitochondrial Biology Unit, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK., Aryaman J; EPSRC Centre for the Mathematics of Precision Healthcare, Department of Mathematics, Imperial College, London, UK., Wei W; Department of Clinical Neurosciences, School of Clinical Medicine, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK.; Medical Research Council Mitochondrial Biology Unit, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK., Klimm F; Department of Clinical Neurosciences, School of Clinical Medicine, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK.; Medical Research Council Mitochondrial Biology Unit, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK.; EPSRC Centre for the Mathematics of Precision Healthcare, Department of Mathematics, Imperial College, London, UK., Calabrese C; Department of Clinical Neurosciences, School of Clinical Medicine, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK.; Medical Research Council Mitochondrial Biology Unit, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK., Burr SP; Department of Clinical Neurosciences, School of Clinical Medicine, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK.; Medical Research Council Mitochondrial Biology Unit, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK., Macabelli CH; Departamento de Genética e Evolução, Universidade Federal de São Carlos, São Carlos 13565-905, Brazil., Viscomi C; Department of Clinical Neurosciences, School of Clinical Medicine, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK.; Medical Research Council Mitochondrial Biology Unit, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK., Saitou M; Department of Anatomy and Cell Biology, Graduate School of Medicine, Kyoto University, Yoshida-Konoe-cho, Sakyo-ku, Kyoto 606-8501, Japan.; JST, ERATO, Yoshida-Konoe-cho, Sakyo-ku, Kyoto 606-8501, Japan., Chiaratti MR; Departamento de Genética e Evolução, Universidade Federal de São Carlos, São Carlos 13565-905, Brazil., Stewart JB; Max Planck Institute for Biology of Ageing, Cologne 50931, Germany.; Biosciences Institute, Faculty of Medical Sciences, Wellcome Centre for Mitochondrial Research, Newcastle University, Newcastle upon Tyne, UK., Jones N; EPSRC Centre for the Mathematics of Precision Healthcare, Department of Mathematics, Imperial College, London, UK.; Leverhulme Centre for Cellular Bionics, Imperial College, London, UK., Chinnery PF; Department of Clinical Neurosciences, School of Clinical Medicine, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK.; Medical Research Council Mitochondrial Biology Unit, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK.
Source: Science advances [Sci Adv] 2021 Dec 10; Vol. 7 (50), pp. eabi5657. Date of Electronic Publication: 2021 Dec 08.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101653440 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2375-2548 (Electronic) Linking ISSN: 23752548 NLM ISO Abbreviation: Sci Adv Subsets: MEDLINE; PubMed not MEDLINE
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