A phase 1b study evaluating the safety and preliminary efficacy of berzosertib in combination with gemcitabine in patients with advanced non-small cell lung cancer.

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Title: A phase 1b study evaluating the safety and preliminary efficacy of berzosertib in combination with gemcitabine in patients with advanced non-small cell lung cancer.
Authors: Plummer R; Newcastle University and Northern Centre for Cancer Care, Newcastle Hospitals NHS Trust, Newcastle Upon Tyne, United Kingdom. Electronic address: Ruth.Plummer@newcastle.ac.uk., Dean E; The University of Manchester and The Christie NHS Foundation Trust, Manchester, United Kingdom. Electronic address: Emma.Dean@doctors.org.uk., Arkenau HT; Sarah Cannon Research Institute, London, United Kingdom. Electronic address: Tobias.Arkenau@hcahealthcare.co.uk., Redfern C; Sharp Healthcare, San Diego, CA, United States., Spira AI; Virginia Cancer Specialists Research Institute and US Oncology Research, Fairfax, VA, United States., Melear JM; Texas Oncology, Austin, TX, United States. Electronic address: Jason.Melear@usoncology.com., Chung KY; Prisma Health, Greenville, SC, United States. Electronic address: Ki.Chung@prismahealth.org., Ferrer-Playan J; Ares Trading SA, Eysins, Switzerland, an affiliate of Merck KGaA, Darmstadt, Germany., Goddemeier T; Merck Healthcare KGaA, Darmstadt, Germany., Locatelli G; Merck Healthcare KGaA, Darmstadt, Germany., Dong J; EMD Serono Research & Development Institute, Inc., Billerica, MA, United States., Fleuranceau-Morel P; EMD Serono Research & Development Institute, Inc., Billerica, MA, United States., Diaz-Padilla I; Ares Trading SA, Eysins, Switzerland, an affiliate of Merck KGaA, Darmstadt, Germany., Shapiro GI; Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, United States. Electronic address: Geoffrey_Shapiro@dfci.harvard.edu.
Source: Lung cancer (Amsterdam, Netherlands) [Lung Cancer] 2022 Jan; Vol. 163, pp. 19-26. Date of Electronic Publication: 2021 Dec 01.
Publication Type: Clinical Trial, Phase I; Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Elsevier Scientific Publishers Country of Publication: Ireland NLM ID: 8800805 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-8332 (Electronic) Linking ISSN: 01695002 NLM ISO Abbreviation: Lung Cancer Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1872-8332
DOI:10.1016/j.lungcan.2021.11.011