Effect of Minimally Invasive Surfactant Therapy vs Sham Treatment on Death or Bronchopulmonary Dysplasia in Preterm Infants With Respiratory Distress Syndrome: The OPTIMIST-A Randomized Clinical Trial.

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Title: Effect of Minimally Invasive Surfactant Therapy vs Sham Treatment on Death or Bronchopulmonary Dysplasia in Preterm Infants With Respiratory Distress Syndrome: The OPTIMIST-A Randomized Clinical Trial.
Authors: Dargaville PA; Menzies Institute for Medical Research, University of Tasmania, Hobart, Australia.; Department of Paediatrics, Royal Hobart Hospital, Hobart, Australia., Kamlin COF; Neonatal Services, Royal Women's Hospital, Melbourne, Australia.; Department of Obstetrics and Gynaecology, University of Melbourne, Melbourne, Australia., Orsini F; Clinical Epidemiology and Biostatistics Unit, Murdoch Children's Research Institute, Melbourne, Australia., Wang X; Clinical Epidemiology and Biostatistics Unit, Murdoch Children's Research Institute, Melbourne, Australia., De Paoli AG; Department of Paediatrics, Royal Hobart Hospital, Hobart, Australia., Kanmaz Kutman HG; Department of Neonatology, Zekai Tahir Burak Maternity Teaching Hospital, Ankara, Turkey., Cetinkaya M; Division of Neonatology, Department of Pediatrics, Istanbul Kanuni Sultan Süleyman Training and Research Hospital, Istanbul, Turkey., Kornhauser-Cerar L; Department of Perinatology, Division of Gynaecology and Obstetrics, University Medical Centre, Ljubljana, Slovenia., Derrick M; Division of Neonatology, NorthShore University Health System, Evanston, Illinois., Özkan H; Department of Pediatrics, Division of Neonatology, Uludağ University Faculty of Medicine, Bursa, Turkey., Hulzebos CV; Division of Neonatology, Beatrix Children's Hospital, University Medical Center Groningen, Groningen, the Netherlands., Schmölzer GM; Division of Neonatology, Department of Pediatrics, University of Alberta, Edmonton, Canada., Aiyappan A; Neonatal Services, Mercy Hospital for Women, Heidelberg, Australia., Lemyre B; Department of Obstetrics, Gynecology, and Newborn Care, Ottawa Hospital, Ottawa, Ontario, Canada., Kuo S; Department of Pediatrics, Kapi'olani Medical Center for Women and Children, Honolulu, Hawaii., Rajadurai VS; Department of Neonatology, KK Women's and Children's Hospital, Duke-NUS Medical School, Singapore., O'Shea J; Neonatal Unit, Royal Hospital for Children, Glasgow, Scotland., Biniwale M; Division of Neonatology, Department of Pediatrics, LAC+USC Medical Center and Good Samaritan Hospital, Keck School of Medicine of USC, Los Angeles, California., Ramanathan R; Division of Neonatology, Department of Pediatrics, LAC+USC Medical Center and Good Samaritan Hospital, Keck School of Medicine of USC, Los Angeles, California., Kushnir A; Department of Pediatrics, Children's Regional Hospital, Cooper University Health Care, Camden, New Jersey., Bader D; Department of Neonatology, Bnai Zion Medical Center, Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel., Thomas MR; Department of Neonatal Medicine, Chelsea and Westminster Hospital NHS Foundation Trust, London, England., Chakraborty M; Regional Neonatal Intensive Care Unit, University Hospital of Wales, Cardiff., Buksh MJ; Newborn Service, Starship Child Health, Auckland Hospital, Auckland, New Zealand., Bhatia R; Monash Newborn, Monash Children's Hospital, Clayton, Australia., Sullivan CL; Department of Neonatology, Singleton Hospital, Swansea, Wales., Shinwell ES; Department of Neonatology, Ziv Medical Center, Faculty of Medicine, Bar-Ilan University, Tsfat, Israel., Dyson A; Department of Neonatology, Centenary Hospital for Women and Children, Canberra Hospital, Woden, Australia., Barker DP; Neonatal Intensive Care Unit, Dunedin Hospital, Dunedin, New Zealand., Kugelman A; Department of Neonatology, Rambam Medical Center, Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel., Donovan TJ; Division of Neonatology, Royal Brisbane and Women's Hospital, Brisbane, Australia., Tauscher MK; Division of Neonatology, Peyton Manning Children's Hospital, Ascension St Vincent, Indianapolis, Indiana., Murthy V; Neonatal Intensive Care Centre, Royal London Hospital-Barts Health NHS Foundation Trust, London, England., Ali SKM; Division of Neonatology, Sidra Medicine, Doha, Qatar., Yossuck P; Department of Pediatrics, WVU Medicine Children's Hospital, Morgantown, West Virginia., Clark HW; Neonatal Intensive Care Unit, Princess Anne Hospital, Southampton, England.; Department of Neonatology, EGA Institute for Women's Health, Faculty of Population Health Sciences, University College London, London, England., Soll RF; Division of Neonatal-Perinatal Medicine, Larner College of Medicine, University of Vermont, Burlington., Carlin JB; Clinical Epidemiology and Biostatistics Unit, Murdoch Children's Research Institute, Melbourne, Australia.; Department of Paediatrics, University of Melbourne, Melbourne, Australia., Davis PG; Neonatal Services, Royal Women's Hospital, Melbourne, Australia.; Department of Obstetrics and Gynaecology, University of Melbourne, Melbourne, Australia.
Corporate Authors: OPTIMIST-A Trial Investigators
Source: JAMA [JAMA] 2021 Dec 28; Vol. 326 (24), pp. 2478-2487.
Publication Type: Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Medical Association Country of Publication: United States NLM ID: 7501160 Publication Model: Print Cited Medium: Internet ISSN: 1538-3598 (Electronic) Linking ISSN: 00987484 NLM ISO Abbreviation: JAMA Subsets: MEDLINE
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  Data: Effect of Minimally Invasive Surfactant Therapy vs Sham Treatment on Death or Bronchopulmonary Dysplasia in Preterm Infants With Respiratory Distress Syndrome: The OPTIMIST-A Randomized Clinical Trial.
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