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Mechanistic Insights into a CDK9 Inhibitor Via Orthogonal Proteomics Methods.

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Title: Mechanistic Insights into a CDK9 Inhibitor Via Orthogonal Proteomics Methods.
Authors: Hendricks JA; Discovery Sciences, AstraZeneca, Boston, Massachusetts 02451, United States., Beaton N; Biognosys AG, Wagistrasse 21, Schlieren 8952, Switzerland., Chernobrovkin A; Pelago Bioscience AB, Banvaktsvägen 20, Solna 17148, Sweden., Miele E; Discovery Sciences, AstraZeneca, Boston, Massachusetts 02451, United States., Hamza GM; Discovery Sciences, AstraZeneca, Boston, Massachusetts 02451, United States.; Molecular, Cellular and Biomedical Sciences, University of New Hampshire, Durham, New Hampshire 03824, United States., Ricchiuto P; Discovery Sciences, AstraZeneca, Cambridge CB4 0WG, U.K., Tomlinson RC; Discovery Sciences, AstraZeneca, Boston, Massachusetts 02451, United States., Friman T; Pelago Bioscience AB, Banvaktsvägen 20, Solna 17148, Sweden., Borenstain C; Discovery Sciences, AstraZeneca, Boston, Massachusetts 02451, United States., Barlaam B; Oncology R&D, AstraZeneca, Cambridge CB4 0WG, U.K., Hande S; Oncology R&D, Boston, Massachusetts 02451, United States., Lamb ML; Oncology R&D, Boston, Massachusetts 02451, United States., De Savi C; Oncology R&D, Boston, Massachusetts 02451, United States., Davies R; Discovery Sciences, AstraZeneca, Cambridge CB4 0WG, U.K., Main M; Discovery Sciences, AstraZeneca, Cambridge CB4 0WG, U.K., Hellner J; Pelago Bioscience AB, Banvaktsvägen 20, Solna 17148, Sweden., Beeler K; Biognosys AG, Wagistrasse 21, Schlieren 8952, Switzerland., Feng Y; Biognosys AG, Wagistrasse 21, Schlieren 8952, Switzerland., Bruderer R; Biognosys AG, Wagistrasse 21, Schlieren 8952, Switzerland., Reiter L; Biognosys AG, Wagistrasse 21, Schlieren 8952, Switzerland., Molina DM; Pelago Bioscience AB, Banvaktsvägen 20, Solna 17148, Sweden., Castaldi MP; Discovery Sciences, AstraZeneca, Boston, Massachusetts 02451, United States.
Source: ACS chemical biology [ACS Chem Biol] 2022 Jan 21; Vol. 17 (1), pp. 54-67. Date of Electronic Publication: 2021 Dec 25.
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101282906 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1554-8937 (Electronic) Linking ISSN: 15548929 NLM ISO Abbreviation: ACS Chem Biol Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Hendricks+JA%22">Hendricks JA</searchLink>; Discovery Sciences, AstraZeneca, Boston, Massachusetts 02451, United States.<br /><searchLink fieldCode="AU" term="%22Beaton+N%22">Beaton N</searchLink>; Biognosys AG, Wagistrasse 21, Schlieren 8952, Switzerland.<br /><searchLink fieldCode="AU" term="%22Chernobrovkin+A%22">Chernobrovkin A</searchLink>; Pelago Bioscience AB, Banvaktsvägen 20, Solna 17148, Sweden.<br /><searchLink fieldCode="AU" term="%22Miele+E%22">Miele E</searchLink>; Discovery Sciences, AstraZeneca, Boston, Massachusetts 02451, United States.<br /><searchLink fieldCode="AU" term="%22Hamza+GM%22">Hamza GM</searchLink>; Discovery Sciences, AstraZeneca, Boston, Massachusetts 02451, United States.; Molecular, Cellular and Biomedical Sciences, University of New Hampshire, Durham, New Hampshire 03824, United States.<br /><searchLink fieldCode="AU" term="%22Ricchiuto+P%22">Ricchiuto P</searchLink>; Discovery Sciences, AstraZeneca, Cambridge CB4 0WG, U.K.<br /><searchLink fieldCode="AU" term="%22Tomlinson+RC%22">Tomlinson RC</searchLink>; Discovery Sciences, AstraZeneca, Boston, Massachusetts 02451, United States.<br /><searchLink fieldCode="AU" term="%22Friman+T%22">Friman T</searchLink>; Pelago Bioscience AB, Banvaktsvägen 20, Solna 17148, Sweden.<br /><searchLink fieldCode="AU" term="%22Borenstain+C%22">Borenstain C</searchLink>; Discovery Sciences, AstraZeneca, Boston, Massachusetts 02451, United States.<br /><searchLink fieldCode="AU" term="%22Barlaam+B%22">Barlaam B</searchLink>; Oncology R&D, AstraZeneca, Cambridge CB4 0WG, U.K.<br /><searchLink fieldCode="AU" term="%22Hande+S%22">Hande S</searchLink>; Oncology R&D, Boston, Massachusetts 02451, United States.<br /><searchLink fieldCode="AU" term="%22Lamb+ML%22">Lamb ML</searchLink>; Oncology R&D, Boston, Massachusetts 02451, United States.<br /><searchLink fieldCode="AU" term="%22De+Savi+C%22">De Savi C</searchLink>; Oncology R&D, Boston, Massachusetts 02451, United States.<br /><searchLink fieldCode="AU" term="%22Davies+R%22">Davies R</searchLink>; Discovery Sciences, AstraZeneca, Cambridge CB4 0WG, U.K.<br /><searchLink fieldCode="AU" term="%22Main+M%22">Main M</searchLink>; Discovery Sciences, AstraZeneca, Cambridge CB4 0WG, U.K.<br /><searchLink fieldCode="AU" term="%22Hellner+J%22">Hellner J</searchLink>; Pelago Bioscience AB, Banvaktsvägen 20, Solna 17148, Sweden.<br /><searchLink fieldCode="AU" term="%22Beeler+K%22">Beeler K</searchLink>; Biognosys AG, Wagistrasse 21, Schlieren 8952, Switzerland.<br /><searchLink fieldCode="AU" term="%22Feng+Y%22">Feng Y</searchLink>; Biognosys AG, Wagistrasse 21, Schlieren 8952, Switzerland.<br /><searchLink fieldCode="AU" term="%22Bruderer+R%22">Bruderer R</searchLink>; Biognosys AG, Wagistrasse 21, Schlieren 8952, Switzerland.<br /><searchLink fieldCode="AU" term="%22Reiter+L%22">Reiter L</searchLink>; Biognosys AG, Wagistrasse 21, Schlieren 8952, Switzerland.<br /><searchLink fieldCode="AU" term="%22Molina+DM%22">Molina DM</searchLink>; Pelago Bioscience AB, Banvaktsvägen 20, Solna 17148, Sweden.<br /><searchLink fieldCode="AU" term="%22Castaldi+MP%22">Castaldi MP</searchLink>; Discovery Sciences, AstraZeneca, Boston, Massachusetts 02451, United States.
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  Data: <searchLink fieldCode="JN" term="%22101282906%22">ACS chemical biology</searchLink> [ACS Chem Biol] 2022 Jan 21; Vol. 17 (1), pp. 54-67. <i>Date of Electronic Publication: </i>2021 Dec 25.
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