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Deciphering the High Viscosity of a Therapeutic Monoclonal Antibody in High Concentration Formulations by Microdialysis-Hydrogen/Deuterium Exchange Mass Spectrometry.

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Title: Deciphering the High Viscosity of a Therapeutic Monoclonal Antibody in High Concentration Formulations by Microdialysis-Hydrogen/Deuterium Exchange Mass Spectrometry.
Authors: Xu X; Analytical Chemistry, Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA. Electronic address: xiaobin.xu@regeneron.com., Zhang A; Analytical Chemistry, Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA., Xu Y; Analytical Chemistry, Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA., Cao Y; Formulation Development, Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA., Cale S; Formulation Development, Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA., Franklin M; Structural Biology, Regeneron Pharmaceutical, Inc., Tarrytown, NY 10591, USA., Sarangapani P; Protein Biochemistry, Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA., Ihnat PM; Protein Biochemistry, Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA., Qiu H; Analytical Chemistry, Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA. Electronic address: haibo.qiu@regeneron.com., Liu D; Formulation Development, Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA., Pyles EA; Protein Biochemistry, Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA., Shameem M; Formulation Development, Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA., Li N; Analytical Chemistry, Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA.
Source: Journal of pharmaceutical sciences [J Pharm Sci] 2022 May; Vol. 111 (5), pp. 1335-1345. Date of Electronic Publication: 2022 Jan 07.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 2985195R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-6017 (Electronic) Linking ISSN: 00223549 NLM ISO Abbreviation: J Pharm Sci Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Xu+X%22">Xu X</searchLink>; Analytical Chemistry, Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA. Electronic address: xiaobin.xu@regeneron.com.<br /><searchLink fieldCode="AU" term="%22Zhang+A%22">Zhang A</searchLink>; Analytical Chemistry, Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA.<br /><searchLink fieldCode="AU" term="%22Xu+Y%22">Xu Y</searchLink>; Analytical Chemistry, Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA.<br /><searchLink fieldCode="AU" term="%22Cao+Y%22">Cao Y</searchLink>; Formulation Development, Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA.<br /><searchLink fieldCode="AU" term="%22Cale+S%22">Cale S</searchLink>; Formulation Development, Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA.<br /><searchLink fieldCode="AU" term="%22Franklin+M%22">Franklin M</searchLink>; Structural Biology, Regeneron Pharmaceutical, Inc., Tarrytown, NY 10591, USA.<br /><searchLink fieldCode="AU" term="%22Sarangapani+P%22">Sarangapani P</searchLink>; Protein Biochemistry, Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA.<br /><searchLink fieldCode="AU" term="%22Ihnat+PM%22">Ihnat PM</searchLink>; Protein Biochemistry, Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA.<br /><searchLink fieldCode="AU" term="%22Qiu+H%22">Qiu H</searchLink>; Analytical Chemistry, Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA. Electronic address: haibo.qiu@regeneron.com.<br /><searchLink fieldCode="AU" term="%22Liu+D%22">Liu D</searchLink>; Formulation Development, Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA.<br /><searchLink fieldCode="AU" term="%22Pyles+EA%22">Pyles EA</searchLink>; Protein Biochemistry, Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA.<br /><searchLink fieldCode="AU" term="%22Shameem+M%22">Shameem M</searchLink>; Formulation Development, Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA.<br /><searchLink fieldCode="AU" term="%22Li+N%22">Li N</searchLink>; Analytical Chemistry, Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA.
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  Data: <searchLink fieldCode="JN" term="%222985195R%22">Journal of pharmaceutical sciences</searchLink> [J Pharm Sci] 2022 May; Vol. 111 (5), pp. 1335-1345. <i>Date of Electronic Publication: </i>2022 Jan 07.
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