View in EDS

Deciphering the High Viscosity of a Therapeutic Monoclonal Antibody in High Concentration Formulations by Microdialysis-Hydrogen/Deuterium Exchange Mass Spectrometry.

Saved in:
Bibliographic Details
Title: Deciphering the High Viscosity of a Therapeutic Monoclonal Antibody in High Concentration Formulations by Microdialysis-Hydrogen/Deuterium Exchange Mass Spectrometry.
Authors: Xu X; Analytical Chemistry, Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA. Electronic address: xiaobin.xu@regeneron.com., Zhang A; Analytical Chemistry, Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA., Xu Y; Analytical Chemistry, Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA., Cao Y; Formulation Development, Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA., Cale S; Formulation Development, Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA., Franklin M; Structural Biology, Regeneron Pharmaceutical, Inc., Tarrytown, NY 10591, USA., Sarangapani P; Protein Biochemistry, Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA., Ihnat PM; Protein Biochemistry, Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA., Qiu H; Analytical Chemistry, Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA. Electronic address: haibo.qiu@regeneron.com., Liu D; Formulation Development, Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA., Pyles EA; Protein Biochemistry, Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA., Shameem M; Formulation Development, Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA., Li N; Analytical Chemistry, Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA.
Source: Journal of pharmaceutical sciences [J Pharm Sci] 2022 May; Vol. 111 (5), pp. 1335-1345. Date of Electronic Publication: 2022 Jan 07.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 2985195R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-6017 (Electronic) Linking ISSN: 00223549 NLM ISO Abbreviation: J Pharm Sci Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1520-6017
DOI:10.1016/j.xphs.2021.12.027