Deciphering the High Viscosity of a Therapeutic Monoclonal Antibody in High Concentration Formulations by Microdialysis-Hydrogen/Deuterium Exchange Mass Spectrometry.
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| Title: | Deciphering the High Viscosity of a Therapeutic Monoclonal Antibody in High Concentration Formulations by Microdialysis-Hydrogen/Deuterium Exchange Mass Spectrometry. |
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| Authors: | Xu X; Analytical Chemistry, Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA. Electronic address: xiaobin.xu@regeneron.com., Zhang A; Analytical Chemistry, Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA., Xu Y; Analytical Chemistry, Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA., Cao Y; Formulation Development, Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA., Cale S; Formulation Development, Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA., Franklin M; Structural Biology, Regeneron Pharmaceutical, Inc., Tarrytown, NY 10591, USA., Sarangapani P; Protein Biochemistry, Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA., Ihnat PM; Protein Biochemistry, Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA., Qiu H; Analytical Chemistry, Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA. Electronic address: haibo.qiu@regeneron.com., Liu D; Formulation Development, Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA., Pyles EA; Protein Biochemistry, Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA., Shameem M; Formulation Development, Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA., Li N; Analytical Chemistry, Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA. |
| Source: | Journal of pharmaceutical sciences [J Pharm Sci] 2022 May; Vol. 111 (5), pp. 1335-1345. Date of Electronic Publication: 2022 Jan 07. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Elsevier Country of Publication: United States NLM ID: 2985195R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-6017 (Electronic) Linking ISSN: 00223549 NLM ISO Abbreviation: J Pharm Sci Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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