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Preclinical and randomized phase I studies of plitidepsin in adults hospitalized with COVID-19.

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Title: Preclinical and randomized phase I studies of plitidepsin in adults hospitalized with COVID-19.
Authors: Varona JF; Departamento de Medicina Interna, Hospital Universitario HM Monteprincipe, HM Hospitales, Madrid, Spain jfvarona@hmhospitales.com.; Facultad de Medicina, Universidad San Pablo-CEU, Madrid, Spain., Landete P; Hospital Universitario La Princesa, Madrid, Spain.; Universidad Autónoma de Madrid, Madrid, Spain., Lopez-Martin JA; Virology and Inflammation Unit, PharmaMar, SA, Madrid, Spain., Estrada V; Hospital Clínico San Carlos, Madrid, Spain.; Universidad Complutense de Madrid, Madrid, Spain., Paredes R; Infectious Diseases Department, IrsiCaixa AIDS Research Institute, Barcelona, Spain.; Hospital Germans Trias I Pujol, Barcelona, Spain., Guisado-Vasco P; Hospital Universitario Quironsalud Madrid, Madrid, Spain.; Universidad Europea, Madrid, Spain., Fernandez de Orueta L; Universidad Europea, Madrid, Spain.; Internal Medicine Department, Hospital Universitario de Getafe, Madrid, Spain., Torralba M; Health Sciences Faculty, University of Alcalá, Madrid, Spain.; Guadalajara University Hospital, Guadalajara, Spain., Fortun J; Hospital Universitario Ramón y Cajal, Madrid, Spain., Vates R; Internal Medicine Department, Hospital Universitario de Getafe, Madrid, Spain., Barberan J; Departamento de Medicina Interna, Hospital Universitario HM Monteprincipe, HM Hospitales, Madrid, Spain.; Facultad de Medicina, Universidad San Pablo-CEU, Madrid, Spain., Clotet B; Infectious Diseases Department, IrsiCaixa AIDS Research Institute, Barcelona, Spain.; Hospital Germans Trias I Pujol, Barcelona, Spain.; Universitat Autònoma de Barcelona, Barcelona, Spain.; Universitat de Vic, Universitat Central de Catalunya, Barcelona, Spain., Ancochea J; Hospital Universitario La Princesa, Madrid, Spain.; Universidad Autónoma de Madrid, Madrid, Spain.; Centro de Investigación en Red de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III (ISCIII), Madrid, Spain., Carnevali D; Hospital Universitario Quironsalud Madrid, Madrid, Spain.; Universidad Europea, Madrid, Spain., Cabello N; Infectious Diseases Department, Clinico San Carlos University Hospital, Madrid, Spain., Porras L; Internal Medicine, Hospital General de Ciudad Real, Ciudad Real, Spain., Gijon P; Clinical Microbiology and Infectious Diseases Department, Hospital General Universitario Gregorio Marañón, Instituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain., Monereo A; Internal Medicine Department, Hospital Universitario de Getafe, Madrid, Spain., Abad D; Universidad Europea, Madrid, Spain.; Internal Medicine Department, Hospital Universitario de Getafe, Madrid, Spain., Zuñiga S; Department of Molecular and Cell Biology, Centro Nacional de Biotecnología (CNB-CSIC), Madrid, Spain., Sola I; Department of Molecular and Cell Biology, Centro Nacional de Biotecnología (CNB-CSIC), Madrid, Spain., Rodon J; IRTA, Centre de Recerca en Sanitat Animal (CReSA, IRTA-UAB), Campus de la UAB, Bellaterra, Spain., Vergara-Alert J; IRTA, Centre de Recerca en Sanitat Animal (CReSA, IRTA-UAB), Campus de la UAB, Bellaterra, Spain., Izquierdo-Useros N; IrsiCaixa AIDS Research Institute, Barcelona, Spain.; Germans Trias I Pujol Research Institute (IGTP), Badalona, Spain., Fudio S; Clinical Pharmacology Unit, PharmaMar, Madrid, Spain., Pontes MJ; Medical Affairs, PharmaMar, Madrid, Spain., de Rivas B; Medical Affairs, PharmaMar, Madrid, Spain., Giron de Velasco P; Virology and Inflammation Unit, PharmaMar, SA, Madrid, Spain., Nieto A; Bio Statistics Unit, PharmaMar, Madrid, Spain., Gomez J; Bio Statistics Unit, PharmaMar, Madrid, Spain., Aviles P; Preclinical Unit, Pharmamar, Madrid, Spain., Lubomirov R; Clinical Pharmacology Unit, PharmaMar, Madrid, Spain., Belgrano A; Bio Statistics Unit, PharmaMar, Madrid, Spain., Sopesen B; Virology and Inflammation Unit, PharmaMar, SA, Madrid, Spain.; Sylentis, SAU, Madrid, Spain.; Biocross, SL, Valladolid, Spain., White KM; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Global Health Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Rosales R; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Global Health Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Yildiz S; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Global Health Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Reuschl AK; Division of Infection and Immunity, University College London, London, UK., Thorne LG; Division of Infection and Immunity, University College London, London, UK., Jolly C; Division of Infection and Immunity, University College London, London, UK., Towers GJ; Division of Infection and Immunity, University College London, London, UK., Zuliani-Alvarez L; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, USA.; J David Gladstone Institutes, San Francisco, CA, USA.; QBI, Coronavirus Research Group (QCRG), San Francisco, CA, USA.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA, USA., Bouhaddou M; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, USA.; J David Gladstone Institutes, San Francisco, CA, USA.; QBI, Coronavirus Research Group (QCRG), San Francisco, CA, USA.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA, USA., Obernier K; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, USA.; J David Gladstone Institutes, San Francisco, CA, USA.; QBI, Coronavirus Research Group (QCRG), San Francisco, CA, USA.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA, USA., McGovern BL; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Global Health Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Rodriguez ML; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Global Health Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Enjuanes L; Department of Molecular and Cell Biology, Centro Nacional de Biotecnología (CNB-CSIC), Madrid, Spain., Fernandez-Sousa JM; Pharmamar, Madrid, Spain., Krogan NJ; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, USA.; J David Gladstone Institutes, San Francisco, CA, USA.; QBI, Coronavirus Research Group (QCRG), San Francisco, CA, USA.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA, USA., Jimeno JM; Virology and Inflammation Unit, PharmaMar, SA, Madrid, Spain., Garcia-Sastre A; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Global Health Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Medicine, Division of Infectious Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Tish Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Source: Life science alliance [Life Sci Alliance] 2022 Jan 10; Vol. 5 (4). Date of Electronic Publication: 2022 Jan 10 (Print Publication: 2022).
Publication Type: Clinical Trial, Phase I; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
Journal Info: Publisher: Life Science Alliance, LLC Country of Publication: United States NLM ID: 101728869 Publication Model: Electronic-Print Cited Medium: Internet ISSN: 2575-1077 (Electronic) Linking ISSN: 25751077 NLM ISO Abbreviation: Life Sci Alliance Subsets: MEDLINE
Database: MEDLINE Ultimate
FullText Links:
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DbLabel: MEDLINE Ultimate
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PubType: Academic Journal
PubTypeId: academicJournal
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  Data: Preclinical and randomized phase I studies of plitidepsin in adults hospitalized with COVID-19.
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  Data: <searchLink fieldCode="AU" term="%22Varona+JF%22">Varona JF</searchLink>; Departamento de Medicina Interna, Hospital Universitario HM Monteprincipe, HM Hospitales, Madrid, Spain jfvarona@hmhospitales.com.; Facultad de Medicina, Universidad San Pablo-CEU, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Landete+P%22">Landete P</searchLink>; Hospital Universitario La Princesa, Madrid, Spain.; Universidad Autónoma de Madrid, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Lopez-Martin+JA%22">Lopez-Martin JA</searchLink>; Virology and Inflammation Unit, PharmaMar, SA, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Estrada+V%22">Estrada V</searchLink>; Hospital Clínico San Carlos, Madrid, Spain.; Universidad Complutense de Madrid, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Paredes+R%22">Paredes R</searchLink>; Infectious Diseases Department, IrsiCaixa AIDS Research Institute, Barcelona, Spain.; Hospital Germans Trias I Pujol, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Guisado-Vasco+P%22">Guisado-Vasco P</searchLink>; Hospital Universitario Quironsalud Madrid, Madrid, Spain.; Universidad Europea, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Fernandez+de+Orueta+L%22">Fernandez de Orueta L</searchLink>; Universidad Europea, Madrid, Spain.; Internal Medicine Department, Hospital Universitario de Getafe, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Torralba+M%22">Torralba M</searchLink>; Health Sciences Faculty, University of Alcalá, Madrid, Spain.; Guadalajara University Hospital, Guadalajara, Spain.<br /><searchLink fieldCode="AU" term="%22Fortun+J%22">Fortun J</searchLink>; Hospital Universitario Ramón y Cajal, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Vates+R%22">Vates R</searchLink>; Internal Medicine Department, Hospital Universitario de Getafe, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Barberan+J%22">Barberan J</searchLink>; Departamento de Medicina Interna, Hospital Universitario HM Monteprincipe, HM Hospitales, Madrid, Spain.; Facultad de Medicina, Universidad San Pablo-CEU, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Clotet+B%22">Clotet B</searchLink>; Infectious Diseases Department, IrsiCaixa AIDS Research Institute, Barcelona, Spain.; Hospital Germans Trias I Pujol, Barcelona, Spain.; Universitat Autònoma de Barcelona, Barcelona, Spain.; Universitat de Vic, Universitat Central de Catalunya, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Ancochea+J%22">Ancochea J</searchLink>; Hospital Universitario La Princesa, Madrid, Spain.; Universidad Autónoma de Madrid, Madrid, Spain.; Centro de Investigación en Red de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III (ISCIII), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Carnevali+D%22">Carnevali D</searchLink>; Hospital Universitario Quironsalud Madrid, Madrid, Spain.; Universidad Europea, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Cabello+N%22">Cabello N</searchLink>; Infectious Diseases Department, Clinico San Carlos University Hospital, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Porras+L%22">Porras L</searchLink>; Internal Medicine, Hospital General de Ciudad Real, Ciudad Real, Spain.<br /><searchLink fieldCode="AU" term="%22Gijon+P%22">Gijon P</searchLink>; Clinical Microbiology and Infectious Diseases Department, Hospital General Universitario Gregorio Marañón, Instituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Monereo+A%22">Monereo A</searchLink>; Internal Medicine Department, Hospital Universitario de Getafe, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Abad+D%22">Abad D</searchLink>; Universidad Europea, Madrid, Spain.; Internal Medicine Department, Hospital Universitario de Getafe, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Zuñiga+S%22">Zuñiga S</searchLink>; Department of Molecular and Cell Biology, Centro Nacional de Biotecnología (CNB-CSIC), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Sola+I%22">Sola I</searchLink>; Department of Molecular and Cell Biology, Centro Nacional de Biotecnología (CNB-CSIC), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Rodon+J%22">Rodon J</searchLink>; IRTA, Centre de Recerca en Sanitat Animal (CReSA, IRTA-UAB), Campus de la UAB, Bellaterra, Spain.<br /><searchLink fieldCode="AU" term="%22Vergara-Alert+J%22">Vergara-Alert J</searchLink>; IRTA, Centre de Recerca en Sanitat Animal (CReSA, IRTA-UAB), Campus de la UAB, Bellaterra, Spain.<br /><searchLink fieldCode="AU" term="%22Izquierdo-Useros+N%22">Izquierdo-Useros N</searchLink>; IrsiCaixa AIDS Research Institute, Barcelona, Spain.; Germans Trias I Pujol Research Institute (IGTP), Badalona, Spain.<br /><searchLink fieldCode="AU" term="%22Fudio+S%22">Fudio S</searchLink>; Clinical Pharmacology Unit, PharmaMar, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Pontes+MJ%22">Pontes MJ</searchLink>; Medical Affairs, PharmaMar, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22de+Rivas+B%22">de Rivas B</searchLink>; Medical Affairs, PharmaMar, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Giron+de+Velasco+P%22">Giron de Velasco P</searchLink>; Virology and Inflammation Unit, PharmaMar, SA, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Nieto+A%22">Nieto A</searchLink>; Bio Statistics Unit, PharmaMar, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Gomez+J%22">Gomez J</searchLink>; Bio Statistics Unit, PharmaMar, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Aviles+P%22">Aviles P</searchLink>; Preclinical Unit, Pharmamar, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Lubomirov+R%22">Lubomirov R</searchLink>; Clinical Pharmacology Unit, PharmaMar, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Belgrano+A%22">Belgrano A</searchLink>; Bio Statistics Unit, PharmaMar, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Sopesen+B%22">Sopesen B</searchLink>; Virology and Inflammation Unit, PharmaMar, SA, Madrid, Spain.; Sylentis, SAU, Madrid, Spain.; Biocross, SL, Valladolid, Spain.<br /><searchLink fieldCode="AU" term="%22White+KM%22">White KM</searchLink>; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Global Health Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Rosales+R%22">Rosales R</searchLink>; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; 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Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, USA.; J David Gladstone Institutes, San Francisco, CA, USA.; QBI, Coronavirus Research Group (QCRG), San Francisco, CA, USA.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Bouhaddou+M%22">Bouhaddou M</searchLink>; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, USA.; J David Gladstone Institutes, San Francisco, CA, USA.; QBI, Coronavirus Research Group (QCRG), San Francisco, CA, USA.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Obernier+K%22">Obernier K</searchLink>; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, USA.; J David Gladstone Institutes, San Francisco, CA, USA.; QBI, Coronavirus Research Group (QCRG), San Francisco, CA, USA.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22McGovern+BL%22">McGovern BL</searchLink>; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Global Health Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Rodriguez+ML%22">Rodriguez ML</searchLink>; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Global Health Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Enjuanes+L%22">Enjuanes L</searchLink>; Department of Molecular and Cell Biology, Centro Nacional de Biotecnología (CNB-CSIC), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Fernandez-Sousa+JM%22">Fernandez-Sousa JM</searchLink>; Pharmamar, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Krogan+NJ%22">Krogan NJ</searchLink>; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, USA.; J David Gladstone Institutes, San Francisco, CA, USA.; QBI, Coronavirus Research Group (QCRG), San Francisco, CA, USA.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Jimeno+JM%22">Jimeno JM</searchLink>; Virology and Inflammation Unit, PharmaMar, SA, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Garcia-Sastre+A%22">Garcia-Sastre A</searchLink>; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Global Health Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Medicine, Division of Infectious Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Tish Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
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  Data: <searchLink fieldCode="JN" term="%22101728869%22">Life science alliance</searchLink> [Life Sci Alliance] 2022 Jan 10; Vol. 5 (4). <i>Date of Electronic Publication: </i>2022 Jan 10 (<i>Print Publication: </i>2022).
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  Data: Clinical Trial, Phase I; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
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            NameFull: Zuliani-Alvarez L
      – PersonEntity:
          Name:
            NameFull: Bouhaddou M
      – PersonEntity:
          Name:
            NameFull: Obernier K
      – PersonEntity:
          Name:
            NameFull: McGovern BL
      – PersonEntity:
          Name:
            NameFull: Rodriguez ML
      – PersonEntity:
          Name:
            NameFull: Enjuanes L
      – PersonEntity:
          Name:
            NameFull: Fernandez-Sousa JM
      – PersonEntity:
          Name:
            NameFull: Krogan NJ
      – PersonEntity:
          Name:
            NameFull: Jimeno JM
      – PersonEntity:
          Name:
            NameFull: Garcia-Sastre A
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 10
              M: 01
              Text: 2022 Jan 10
              Type: published
              Y: 2022
          Identifiers:
            – Type: issn-electronic
              Value: 2575-1077
          Numbering:
            – Type: volume
              Value: 5
            – Type: issue
              Value: 4
          Titles:
            – TitleFull: Life science alliance
              Type: main
ResultId 1