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Interaction Testing and Polygenic Risk Scoring to Estimate the Association of Common Genetic Variants With Treatment Resistance in Schizophrenia.

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Title: Interaction Testing and Polygenic Risk Scoring to Estimate the Association of Common Genetic Variants With Treatment Resistance in Schizophrenia.
Authors: Pardiñas AF; MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, School of Medicine, Cardiff University, Cardiff, United Kingdom., Smart SE; MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, School of Medicine, Cardiff University, Cardiff, United Kingdom.; Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, United Kingdom., Willcocks IR; MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, School of Medicine, Cardiff University, Cardiff, United Kingdom., Holmans PA; MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, School of Medicine, Cardiff University, Cardiff, United Kingdom., Dennison CA; MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, School of Medicine, Cardiff University, Cardiff, United Kingdom., Lynham AJ; MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, School of Medicine, Cardiff University, Cardiff, United Kingdom., Legge SE; MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, School of Medicine, Cardiff University, Cardiff, United Kingdom., Baune BT; Department of Psychiatry, University of Münster, Münster, Germany.; Department of Psychiatry, Melbourne Medical School, The University of Melbourne, Melbourne, Australia.; The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne, Australia., Bigdeli TB; Department of Psychiatry and the Behavioral Sciences, State University of New York Downstate Medical Center, Brooklyn.; Institute for Genomic Health, State University of New York Downstate Medical Center, Brooklyn.; Department of Psychiatry, Veterans Affairs New York Harbor Healthcare System, Brooklyn., Cairns MJ; School of Biomedical Sciences and Pharmacy, University of Newcastle, Newcastle, Australia.; Centre for Brain and Mental Health Research, University of Newcastle, Newcastle, Australia.; Hunter Medical Research Institute, Newcastle, Australia., Corvin A; Neuropsychiatric Genetics Research Group, Department of Psychiatry, Trinity College Dublin, Dublin, Ireland., Fanous AH; Department of Psychiatry and the Behavioral Sciences, State University of New York Downstate Medical Center, Brooklyn.; Institute for Genomic Health, State University of New York Downstate Medical Center, Brooklyn., Frank J; Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Heidelberg, Mannheim, Germany., Kelly B; School of Medicine & Public Health, The University of Newcastle, Newcastle, Australia., McQuillin A; Molecular Psychiatry Laboratory, Division of Psychiatry, University College London, London, United Kingdom., Melle I; Norwegian Centre for Mental Disorders Research, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; Division of Mental Health and Addiction, Institute of Clinical Medicine, Oslo University Hospital, Oslo, Norway., Mortensen PB; National Centre for Register-based Research, Aarhus University, Aarhus, Denmark.; The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark., Mowry BJ; Queensland Brain Institute, The University of Queensland, Brisbane, Australia.; Queensland Centre for Mental Health Research, The University of Queensland, Brisbane, Australia., Pato CN; Department of Psychiatry and Behavioral Sciences, State University of New York Downstate Medical Center, Brooklyn.; Department of Psychiatry and Zilkha Neurogenetics Institute, Keck School of Medicine, University of Southern California, Los Angeles.; Institute for Genomic Health, State University of New York Downstate Medical Center, Brooklyn., Periyasamy S; Queensland Brain Institute, The University of Queensland, Brisbane, Australia.; Queensland Centre for Mental Health Research, The University of Queensland, Brisbane, Australia., Rietschel M; Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Heidelberg, Mannheim, Germany., Rujescu D; University Clinic and Outpatient Clinic for Psychiatry, Psychotherapy and Psychosomatics, Martin Luther University of Halle-Wittenberg, Halle, Germany.; Division of General Psychiatry, Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria., Simonsen C; Norwegian Centre for Mental Disorders Research, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; Early Intervention in Psychosis Advisory Unit for South-East Norway, Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway., St Clair D; Institute of Medical Sciences, University of Aberdeen, Aberdeen, United Kingdom., Tooney P; School of Biomedical Sciences and Pharmacy, University of Newcastle, Newcastle, Australia.; Hunter Medical Research Institute, Newcastle, Australia., Wu JQ; Baker Heart and Diabetes Institute, Melbourne, Australia., Andreassen OA; Norwegian Centre for Mental Disorders Research, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; Division of Mental Health and Addiction, Institute of Clinical Medicine, Oslo University Hospital, Oslo, Norway., Kowalec K; College of Pharmacy, University of Manitoba, Winnipeg, Manitoba, Canada.; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden., Sullivan PF; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.; Department of Psychiatry, Icahn School of Medicine, Mount Sinai Hospital, New York, New York.; Department of Genetics, University of North Carolina, Chapel Hill., Murray RM; Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, United Kingdom., Owen MJ; MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, School of Medicine, Cardiff University, Cardiff, United Kingdom., MacCabe JH; Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, United Kingdom., O'Donovan MC; MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, School of Medicine, Cardiff University, Cardiff, United Kingdom., Walters JTR; MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, School of Medicine, Cardiff University, Cardiff, United Kingdom., Ajnakina O; Department of Biostatistics & Health Informatics, Institute of Psychiatry, Psychology & Neuroscience, King's College London, University of London, London, United Kingdom.; Department of Behavioural Science and Health, Institute of Epidemiology and Health Care, University College London, London, United Kingdom., Alameda L; Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, United Kingdom.; Centro de Investigacion Biomedica en Red de Salud Mental, Spanish Network for Research in Mental Health, Sevilla, Spain.; Instituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Rocio, Departamento de Psiquiatria, Universidad de Sevilla, Sevilla, Spain.; Treatment and Early Intervention in Psychosis Program, Service of General Psychiatry, Department of Psychiatry, Lausanne University Hospital, Lausanne, Switzerland., Barnes TRE; Division of Psychiatry, Imperial College London, London, United Kingdom., Berardi D; Department of Biomedical and Neuro-motor Sciences, Psychiatry Unit, Alma Mater Studiorum Università di Bologna, Bologna, Italy., Bonora E; Department of Medical and Surgical Sciences, Bologna Transcultural Psychosomatic Team, Alma Mater Studiorum, University of Bologna, Bologna, Italy., Camporesi S; Treatment and Early Intervention in Psychosis Program, Service of General Psychiatry, Department of Psychiatry, Lausanne University Hospital, Lausanne, Switzerland.; Unit for Research in Schizophrenia, Center for Psychiatric Neuroscience, Department of Psychiatry, Lausanne University Hospital, Lausanne, Switzerland., Cleusix M; Unit for Research in Schizophrenia, Center for Psychiatric Neuroscience, Department of Psychiatry, Lausanne University Hospital, Lausanne, Switzerland., Conus P; Treatment and Early Intervention in Psychosis Program, Service of General Psychiatry, Department of Psychiatry, Lausanne University Hospital, Lausanne, Switzerland., Crespo-Facorro B; Centro de Investigacion Biomedica en Red de Salud Mental, Spanish Network for Research in Mental Health, Sevilla, Spain.; Instituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Rocio, Departamento de Psiquiatria, Universidad de Sevilla, Sevilla, Spain., D'Andrea G; Department of Biomedical and Neuro-motor Sciences, Psychiatry Unit, Alma Mater Studiorum Università di Bologna, Bologna, Italy., Demjaha A; Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, United Kingdom., Do KQ; Unit for Research in Schizophrenia, Center for Psychiatric Neuroscience, Department of Psychiatry, Lausanne University Hospital, Lausanne, Switzerland., Doody GA; Department of Medical Education, University of Nottingham Faculty of Medicine and Health Sciences, Nottingham, United Kingdom., Eap CB; Unit of Pharmacogenetics and Clinical Psychopharmacology, Centre for Psychiatric Neuroscience, Department of Psychiatry, Lausanne University Hospital, University of Lausanne, Prilly, Switzerland.; School of Pharmaceutical Sciences, University of Geneva, Geneva, Switzerland.; Center for Research and Innovation in Clinical Pharmaceutical Sciences, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.; Institute of Pharmaceutical Sciences of Western Switzerland, University of Geneva, Geneva, Switzerland., Ferchiou A; University Paris-Est Créteil, Institut national de la santé et de la recherche médicale, Mondor Institute for Biomedical Research, Translational Neuropsychiatry, Fondation FondaMental, Créteil, France., Di Forti M; Social Genetics and Developmental Psychiatry, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, United Kingdom.; South London and Maudsley National Health Service Mental Health Foundation Trust, London, United Kingdom., Guidi L; Department of Medical and Surgical Sciences, Bologna Transcultural Psychosomatic Team, Alma Mater Studiorum, University of Bologna, Bologna, Italy., Homman L; Department of Social and Welfare Studies, Department of Behavioural Sciences and Learning, Linköping University, Linköping, Sweden.; Centre For Public Health, Institute Of Clinical Sciences, Queens University Belfast, Belfast, United Kingdom., Jenni R; Unit for Research in Schizophrenia, Center for Psychiatric Neuroscience, Department of Psychiatry, Lausanne University Hospital, Lausanne, Switzerland., Joyce EM; UCL Queen Square Institute of Neurology, University College London, London, United Kingdom., Kassoumeri L; Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, United Kingdom., Khadimallah I; Unit for Research in Schizophrenia, Center for Psychiatric Neuroscience, Department of Psychiatry, Lausanne University Hospital, Lausanne, Switzerland., Lastrina O; Department of Biomedical and Neuro-motor Sciences, Psychiatry Unit, Alma Mater Studiorum Università di Bologna, Bologna, Italy., Muratori R; Department of Medical and Surgical Sciences, Bologna Transcultural Psychosomatic Team, Alma Mater Studiorum, University of Bologna, Bologna, Italy., Noyan H; Faculty of Social Sciences, Department of Psychology, Beykoz University, Istanbul, Turkey., O'Neill FA; Centre For Public Health, Institute Of Clinical Sciences, Queens University Belfast, Belfast, United Kingdom., Pignon B; University Paris-Est Créteil, Institut national de la santé et de la recherche médicale, Mondor Institute for Biomedical Research, Translational Neuropsychiatry, Fondation FondaMental, Créteil, France.; Assistance Publique-Hôpitaux de Paris, Hôpitaux Universitaires HMondor, Département Médico-Universitaire de Psychiatrie et d'Addictologie, Fédération Hospitalo-Universitaire de Médecine de Précision, Créteil, France., Restellini R; Treatment and Early Intervention in Psychosis Program, Service of General Psychiatry, Department of Psychiatry, Lausanne University Hospital, Lausanne, Switzerland.; Unit for Research in Schizophrenia, Center for Psychiatric Neuroscience, Department of Psychiatry, Lausanne University Hospital, Lausanne, Switzerland., Richard JR; University Paris-Est Créteil, Institut national de la santé et de la recherche médicale, Mondor Institute for Biomedical Research, Translational Neuropsychiatry, Fondation FondaMental, Créteil, France., Schürhoff F; University Paris-Est Créteil, Institut national de la santé et de la recherche médicale, Mondor Institute for Biomedical Research, Translational Neuropsychiatry, Fondation FondaMental, Créteil, France.; Assistance Publique-Hôpitaux de Paris, Hôpitaux Universitaires HMondor, Département Médico-Universitaire de Psychiatrie et d'Addictologie, Fédération Hospitalo-Universitaire de Médecine de Précision, Créteil, France., Španiel F; Department of Applied Neuroscience and Neuroimaging, National Institute of Mental Health, Klecany, Czechia.; Department of Psychiatry and Medical Psychology, Third Faculty of Medicine, Charles University, Prague, Czechia., Szöke A; University Paris-Est Créteil, Institut national de la santé et de la recherche médicale, Mondor Institute for Biomedical Research, Translational Neuropsychiatry, Fondation FondaMental, Créteil, France.; Assistance Publique-Hôpitaux de Paris, Hôpitaux Universitaires HMondor, Département Médico-Universitaire de Psychiatrie et d'Addictologie, Fédération Hospitalo-Universitaire de Médecine de Précision, Créteil, France., Tarricone I; Department of Medical and Surgical Sciences, Bologna Transcultural Psychosomatic Team, Alma Mater Studiorum, University of Bologna, Bologna, Italy., Tortelli A; University Paris-Est Créteil, Institut national de la santé et de la recherche médicale, Mondor Institute for Biomedical Research, Translational Neuropsychiatry, Fondation FondaMental, Créteil, France.; Groupe Hospitalier Universitaire Psychiatrie Neurosciences Paris, Pôle Psychiatrie Précarité, Paris, France., Üçok A; Department of Psychiatry, Istanbul University, Istanbul, Turkey., Vázquez-Bourgon J; Department of Psychiatry, University Hospital Marques de Valdecilla-Instituto de Investigación Marques de Valdecilla, Santander, Spain.; Department of Medicine and Psychiatry, School of Medicine, University of Cantabria, Santander, Spain.; Centro de Investigacion Biomedica en Red de Salud Mental, Spanish Network for Research in Mental Health, Santander, Spain.
Corporate Authors: Genetics Workstream of the Schizophrenia Treatment Resistance and Therapeutic Advances (STRATA) Consortium and the Schizophrenia Working Group of the Psychiatric Genomics Consortium (PGC)
Source: JAMA psychiatry [JAMA Psychiatry] 2022 Mar 01; Vol. 79 (3), pp. 260-269.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Medical Association Country of Publication: United States NLM ID: 101589550 Publication Model: Print Cited Medium: Internet ISSN: 2168-6238 (Electronic) Linking ISSN: 2168622X NLM ISO Abbreviation: JAMA Psychiatry Subsets: MEDLINE
Database: MEDLINE Ultimate
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Items – Name: Title
  Label: Title
  Group: Ti
  Data: Interaction Testing and Polygenic Risk Scoring to Estimate the Association of Common Genetic Variants With Treatment Resistance in Schizophrenia.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22Pardiñas+AF%22">Pardiñas AF</searchLink>; MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, School of Medicine, Cardiff University, Cardiff, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Smart+SE%22">Smart SE</searchLink>; MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, School of Medicine, Cardiff University, Cardiff, United Kingdom.; Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Willcocks+IR%22">Willcocks IR</searchLink>; MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, School of Medicine, Cardiff University, Cardiff, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Holmans+PA%22">Holmans PA</searchLink>; MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, School of Medicine, Cardiff University, Cardiff, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Dennison+CA%22">Dennison CA</searchLink>; MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, School of Medicine, Cardiff University, Cardiff, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Lynham+AJ%22">Lynham AJ</searchLink>; MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, School of Medicine, Cardiff University, Cardiff, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Legge+SE%22">Legge SE</searchLink>; MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, School of Medicine, Cardiff University, Cardiff, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Baune+BT%22">Baune BT</searchLink>; Department of Psychiatry, University of Münster, Münster, Germany.; Department of Psychiatry, Melbourne Medical School, The University of Melbourne, Melbourne, Australia.; The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne, Australia.<br /><searchLink fieldCode="AU" term="%22Bigdeli+TB%22">Bigdeli TB</searchLink>; Department of Psychiatry and the Behavioral Sciences, State University of New York Downstate Medical Center, Brooklyn.; Institute for Genomic Health, State University of New York Downstate Medical Center, Brooklyn.; Department of Psychiatry, Veterans Affairs New York Harbor Healthcare System, Brooklyn.<br /><searchLink fieldCode="AU" term="%22Cairns+MJ%22">Cairns MJ</searchLink>; School of Biomedical Sciences and Pharmacy, University of Newcastle, Newcastle, Australia.; Centre for Brain and Mental Health Research, University of Newcastle, Newcastle, Australia.; Hunter Medical Research Institute, Newcastle, Australia.<br /><searchLink fieldCode="AU" term="%22Corvin+A%22">Corvin A</searchLink>; Neuropsychiatric Genetics Research Group, Department of Psychiatry, Trinity College Dublin, Dublin, Ireland.<br /><searchLink fieldCode="AU" term="%22Fanous+AH%22">Fanous AH</searchLink>; Department of Psychiatry and the Behavioral Sciences, State University of New York Downstate Medical Center, Brooklyn.; Institute for Genomic Health, State University of New York Downstate Medical Center, Brooklyn.<br /><searchLink fieldCode="AU" term="%22Frank+J%22">Frank J</searchLink>; Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Heidelberg, Mannheim, Germany.<br /><searchLink fieldCode="AU" term="%22Kelly+B%22">Kelly B</searchLink>; School of Medicine & Public Health, The University of Newcastle, Newcastle, Australia.<br /><searchLink fieldCode="AU" term="%22McQuillin+A%22">McQuillin A</searchLink>; Molecular Psychiatry Laboratory, Division of Psychiatry, University College London, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Melle+I%22">Melle I</searchLink>; Norwegian Centre for Mental Disorders Research, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; Division of Mental Health and Addiction, Institute of Clinical Medicine, Oslo University Hospital, Oslo, Norway.<br /><searchLink fieldCode="AU" term="%22Mortensen+PB%22">Mortensen PB</searchLink>; National Centre for Register-based Research, Aarhus University, Aarhus, Denmark.; The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.<br /><searchLink fieldCode="AU" term="%22Mowry+BJ%22">Mowry BJ</searchLink>; Queensland Brain Institute, The University of Queensland, Brisbane, Australia.; Queensland Centre for Mental Health Research, The University of Queensland, Brisbane, Australia.<br /><searchLink fieldCode="AU" term="%22Pato+CN%22">Pato CN</searchLink>; Department of Psychiatry and Behavioral Sciences, State University of New York Downstate Medical Center, Brooklyn.; Department of Psychiatry and Zilkha Neurogenetics Institute, Keck School of Medicine, University of Southern California, Los Angeles.; Institute for Genomic Health, State University of New York Downstate Medical Center, Brooklyn.<br /><searchLink fieldCode="AU" term="%22Periyasamy+S%22">Periyasamy S</searchLink>; Queensland Brain Institute, The University of Queensland, Brisbane, Australia.; Queensland Centre for Mental Health Research, The University of Queensland, Brisbane, Australia.<br /><searchLink fieldCode="AU" term="%22Rietschel+M%22">Rietschel M</searchLink>; Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Heidelberg, Mannheim, Germany.<br /><searchLink fieldCode="AU" term="%22Rujescu+D%22">Rujescu D</searchLink>; University Clinic and Outpatient Clinic for Psychiatry, Psychotherapy and Psychosomatics, Martin Luther University of Halle-Wittenberg, Halle, Germany.; Division of General Psychiatry, Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Simonsen+C%22">Simonsen C</searchLink>; Norwegian Centre for Mental Disorders Research, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; Early Intervention in Psychosis Advisory Unit for South-East Norway, Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.<br /><searchLink fieldCode="AU" term="%22St+Clair+D%22">St Clair D</searchLink>; Institute of Medical Sciences, University of Aberdeen, Aberdeen, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Tooney+P%22">Tooney P</searchLink>; School of Biomedical Sciences and Pharmacy, University of Newcastle, Newcastle, Australia.; Hunter Medical Research Institute, Newcastle, Australia.<br /><searchLink fieldCode="AU" term="%22Wu+JQ%22">Wu JQ</searchLink>; Baker Heart and Diabetes Institute, Melbourne, Australia.<br /><searchLink fieldCode="AU" term="%22Andreassen+OA%22">Andreassen OA</searchLink>; Norwegian Centre for Mental Disorders Research, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; Division of Mental Health and Addiction, Institute of Clinical Medicine, Oslo University Hospital, Oslo, Norway.<br /><searchLink fieldCode="AU" term="%22Kowalec+K%22">Kowalec K</searchLink>; College of Pharmacy, University of Manitoba, Winnipeg, Manitoba, Canada.; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Sullivan+PF%22">Sullivan PF</searchLink>; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.; Department of Psychiatry, Icahn School of Medicine, Mount Sinai Hospital, New York, New York.; Department of Genetics, University of North Carolina, Chapel Hill.<br /><searchLink fieldCode="AU" term="%22Murray+RM%22">Murray RM</searchLink>; Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Owen+MJ%22">Owen MJ</searchLink>; MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, School of Medicine, Cardiff University, Cardiff, United Kingdom.<br /><searchLink fieldCode="AU" term="%22MacCabe+JH%22">MacCabe JH</searchLink>; Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22O'Donovan+MC%22">O'Donovan MC</searchLink>; MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, School of Medicine, Cardiff University, Cardiff, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Walters+JTR%22">Walters JTR</searchLink>; MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, School of Medicine, Cardiff University, Cardiff, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Ajnakina+O%22">Ajnakina O</searchLink>; Department of Biostatistics & Health Informatics, Institute of Psychiatry, Psychology & Neuroscience, King's College London, University of London, London, United Kingdom.; Department of Behavioural Science and Health, Institute of Epidemiology and Health Care, University College London, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Alameda+L%22">Alameda L</searchLink>; Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, United Kingdom.; Centro de Investigacion Biomedica en Red de Salud Mental, Spanish Network for Research in Mental Health, Sevilla, Spain.; Instituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Rocio, Departamento de Psiquiatria, Universidad de Sevilla, Sevilla, Spain.; Treatment and Early Intervention in Psychosis Program, Service of General Psychiatry, Department of Psychiatry, Lausanne University Hospital, Lausanne, Switzerland.<br /><searchLink fieldCode="AU" term="%22Barnes+TRE%22">Barnes TRE</searchLink>; Division of Psychiatry, Imperial College London, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Berardi+D%22">Berardi D</searchLink>; Department of Biomedical and Neuro-motor Sciences, Psychiatry Unit, Alma Mater Studiorum Università di Bologna, Bologna, Italy.<br /><searchLink fieldCode="AU" term="%22Bonora+E%22">Bonora E</searchLink>; Department of Medical and Surgical Sciences, Bologna Transcultural Psychosomatic Team, Alma Mater Studiorum, University of Bologna, Bologna, Italy.<br /><searchLink fieldCode="AU" term="%22Camporesi+S%22">Camporesi S</searchLink>; Treatment and Early Intervention in Psychosis Program, Service of General Psychiatry, Department of Psychiatry, Lausanne University Hospital, Lausanne, Switzerland.; Unit for Research in Schizophrenia, Center for Psychiatric Neuroscience, Department of Psychiatry, Lausanne University Hospital, Lausanne, Switzerland.<br /><searchLink fieldCode="AU" term="%22Cleusix+M%22">Cleusix M</searchLink>; Unit for Research in Schizophrenia, Center for Psychiatric Neuroscience, Department of Psychiatry, Lausanne University Hospital, Lausanne, Switzerland.<br /><searchLink fieldCode="AU" term="%22Conus+P%22">Conus P</searchLink>; Treatment and Early Intervention in Psychosis Program, Service of General Psychiatry, Department of Psychiatry, Lausanne University Hospital, Lausanne, Switzerland.<br /><searchLink fieldCode="AU" term="%22Crespo-Facorro+B%22">Crespo-Facorro B</searchLink>; Centro de Investigacion Biomedica en Red de Salud Mental, Spanish Network for Research in Mental Health, Sevilla, Spain.; Instituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Rocio, Departamento de Psiquiatria, Universidad de Sevilla, Sevilla, Spain.<br /><searchLink fieldCode="AU" term="%22D'Andrea+G%22">D'Andrea G</searchLink>; Department of Biomedical and Neuro-motor Sciences, Psychiatry Unit, Alma Mater Studiorum Università di Bologna, Bologna, Italy.<br /><searchLink fieldCode="AU" term="%22Demjaha+A%22">Demjaha A</searchLink>; Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Do+KQ%22">Do KQ</searchLink>; Unit for Research in Schizophrenia, Center for Psychiatric Neuroscience, Department of Psychiatry, Lausanne University Hospital, Lausanne, Switzerland.<br /><searchLink fieldCode="AU" term="%22Doody+GA%22">Doody GA</searchLink>; Department of Medical Education, University of Nottingham Faculty of Medicine and Health Sciences, Nottingham, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Eap+CB%22">Eap CB</searchLink>; Unit of Pharmacogenetics and Clinical Psychopharmacology, Centre for Psychiatric Neuroscience, Department of Psychiatry, Lausanne University Hospital, University of Lausanne, Prilly, Switzerland.; School of Pharmaceutical Sciences, University of Geneva, Geneva, Switzerland.; Center for Research and Innovation in Clinical Pharmaceutical Sciences, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.; Institute of Pharmaceutical Sciences of Western Switzerland, University of Geneva, Geneva, Switzerland.<br /><searchLink fieldCode="AU" term="%22Ferchiou+A%22">Ferchiou A</searchLink>; University Paris-Est Créteil, Institut national de la santé et de la recherche médicale, Mondor Institute for Biomedical Research, Translational Neuropsychiatry, Fondation FondaMental, Créteil, France.<br /><searchLink fieldCode="AU" term="%22Di+Forti+M%22">Di Forti M</searchLink>; Social Genetics and Developmental Psychiatry, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, United Kingdom.; South London and Maudsley National Health Service Mental Health Foundation Trust, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Guidi+L%22">Guidi L</searchLink>; Department of Medical and Surgical Sciences, Bologna Transcultural Psychosomatic Team, Alma Mater Studiorum, University of Bologna, Bologna, Italy.<br /><searchLink fieldCode="AU" term="%22Homman+L%22">Homman L</searchLink>; Department of Social and Welfare Studies, Department of Behavioural Sciences and Learning, Linköping University, Linköping, Sweden.; Centre For Public Health, Institute Of Clinical Sciences, Queens University Belfast, Belfast, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Jenni+R%22">Jenni R</searchLink>; Unit for Research in Schizophrenia, Center for Psychiatric Neuroscience, Department of Psychiatry, Lausanne University Hospital, Lausanne, Switzerland.<br /><searchLink fieldCode="AU" term="%22Joyce+EM%22">Joyce EM</searchLink>; UCL Queen Square Institute of Neurology, University College London, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Kassoumeri+L%22">Kassoumeri L</searchLink>; Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Khadimallah+I%22">Khadimallah I</searchLink>; Unit for Research in Schizophrenia, Center for Psychiatric Neuroscience, Department of Psychiatry, Lausanne University Hospital, Lausanne, Switzerland.<br /><searchLink fieldCode="AU" term="%22Lastrina+O%22">Lastrina O</searchLink>; Department of Biomedical and Neuro-motor Sciences, Psychiatry Unit, Alma Mater Studiorum Università di Bologna, Bologna, Italy.<br /><searchLink fieldCode="AU" term="%22Muratori+R%22">Muratori R</searchLink>; Department of Medical and Surgical Sciences, Bologna Transcultural Psychosomatic Team, Alma Mater Studiorum, University of Bologna, Bologna, Italy.<br /><searchLink fieldCode="AU" term="%22Noyan+H%22">Noyan H</searchLink>; Faculty of Social Sciences, Department of Psychology, Beykoz University, Istanbul, Turkey.<br /><searchLink fieldCode="AU" term="%22O'Neill+FA%22">O'Neill FA</searchLink>; Centre For Public Health, Institute Of Clinical Sciences, Queens University Belfast, Belfast, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Pignon+B%22">Pignon B</searchLink>; University Paris-Est Créteil, Institut national de la santé et de la recherche médicale, Mondor Institute for Biomedical Research, Translational Neuropsychiatry, Fondation FondaMental, Créteil, France.; Assistance Publique-Hôpitaux de Paris, Hôpitaux Universitaires HMondor, Département Médico-Universitaire de Psychiatrie et d'Addictologie, Fédération Hospitalo-Universitaire de Médecine de Précision, Créteil, France.<br /><searchLink fieldCode="AU" term="%22Restellini+R%22">Restellini R</searchLink>; Treatment and Early Intervention in Psychosis Program, Service of General Psychiatry, Department of Psychiatry, Lausanne University Hospital, Lausanne, Switzerland.; Unit for Research in Schizophrenia, Center for Psychiatric Neuroscience, Department of Psychiatry, Lausanne University Hospital, Lausanne, Switzerland.<br /><searchLink fieldCode="AU" term="%22Richard+JR%22">Richard JR</searchLink>; University Paris-Est Créteil, Institut national de la santé et de la recherche médicale, Mondor Institute for Biomedical Research, Translational Neuropsychiatry, Fondation FondaMental, Créteil, France.<br /><searchLink fieldCode="AU" term="%22Schürhoff+F%22">Schürhoff F</searchLink>; University Paris-Est Créteil, Institut national de la santé et de la recherche médicale, Mondor Institute for Biomedical Research, Translational Neuropsychiatry, Fondation FondaMental, Créteil, France.; Assistance Publique-Hôpitaux de Paris, Hôpitaux Universitaires HMondor, Département Médico-Universitaire de Psychiatrie et d'Addictologie, Fédération Hospitalo-Universitaire de Médecine de Précision, Créteil, France.<br /><searchLink fieldCode="AU" term="%22Španiel+F%22">Španiel F</searchLink>; Department of Applied Neuroscience and Neuroimaging, National Institute of Mental Health, Klecany, Czechia.; Department of Psychiatry and Medical Psychology, Third Faculty of Medicine, Charles University, Prague, Czechia.<br /><searchLink fieldCode="AU" term="%22Szöke+A%22">Szöke A</searchLink>; University Paris-Est Créteil, Institut national de la santé et de la recherche médicale, Mondor Institute for Biomedical Research, Translational Neuropsychiatry, Fondation FondaMental, Créteil, France.; Assistance Publique-Hôpitaux de Paris, Hôpitaux Universitaires HMondor, Département Médico-Universitaire de Psychiatrie et d'Addictologie, Fédération Hospitalo-Universitaire de Médecine de Précision, Créteil, France.<br /><searchLink fieldCode="AU" term="%22Tarricone+I%22">Tarricone I</searchLink>; Department of Medical and Surgical Sciences, Bologna Transcultural Psychosomatic Team, Alma Mater Studiorum, University of Bologna, Bologna, Italy.<br /><searchLink fieldCode="AU" term="%22Tortelli+A%22">Tortelli A</searchLink>; University Paris-Est Créteil, Institut national de la santé et de la recherche médicale, Mondor Institute for Biomedical Research, Translational Neuropsychiatry, Fondation FondaMental, Créteil, France.; Groupe Hospitalier Universitaire Psychiatrie Neurosciences Paris, Pôle Psychiatrie Précarité, Paris, France.<br /><searchLink fieldCode="AU" term="%22Üçok+A%22">Üçok A</searchLink>; Department of Psychiatry, Istanbul University, Istanbul, Turkey.<br /><searchLink fieldCode="AU" term="%22Vázquez-Bourgon+J%22">Vázquez-Bourgon J</searchLink>; Department of Psychiatry, University Hospital Marques de Valdecilla-Instituto de Investigación Marques de Valdecilla, Santander, Spain.; Department of Medicine and Psychiatry, School of Medicine, University of Cantabria, Santander, Spain.; Centro de Investigacion Biomedica en Red de Salud Mental, Spanish Network for Research in Mental Health, Santander, Spain.
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  Data: <searchLink fieldCode="CA" term="%22Genetics+Workstream+of+the+Schizophrenia+Treatment+Resistance+and+Therapeutic+Advances+%28STRATA%29+Consortium+and+the+Schizophrenia+Working+Group+of+the+Psychiatric+Genomics+Consortium+%28PGC%29%22">Genetics Workstream of the Schizophrenia Treatment Resistance and Therapeutic Advances (STRATA) Consortium and the Schizophrenia Working Group of the Psychiatric Genomics Consortium (PGC)</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22101589550%22">JAMA psychiatry</searchLink> [JAMA Psychiatry] 2022 Mar 01; Vol. 79 (3), pp. 260-269.
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        Text: English
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      – TitleFull: Interaction Testing and Polygenic Risk Scoring to Estimate the Association of Common Genetic Variants With Treatment Resistance in Schizophrenia.
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