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Crystal structures of alphavirus nonstructural protein 4 (nsP4) reveal an intrinsically dynamic RNA-dependent RNA polymerase fold.

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Title: Crystal structures of alphavirus nonstructural protein 4 (nsP4) reveal an intrinsically dynamic RNA-dependent RNA polymerase fold.
Authors: Tan YB; Lee Kong Chian School of Medicine, Nanyang Technological University, 59 Nanyang Drive, Singapore 636921.; NTU Institute of Structural Biology, Nanyang Technological University, 59 Nanyang Drive, Singapore 636921., Lello LS; University of Tartu, Institute of Technology, Nooruse 1, 50411 Tartu, Estonia., Liu X; Shanghai Institute of Materia Medica, China Academy of Sciences, 555 Zu Chong Zhi Road, Zhang Jiang Hi-Tech Park, Pudong, Shanghai, China., Law YS; Lee Kong Chian School of Medicine, Nanyang Technological University, 59 Nanyang Drive, Singapore 636921.; NTU Institute of Structural Biology, Nanyang Technological University, 59 Nanyang Drive, Singapore 636921., Kang C; Experimental Drug Development Centre, Agency for Science, Technology and Research (A*STAR), 10 Biopolis Rd, #05-01/06 Chromos, Singapore138670., Lescar J; NTU Institute of Structural Biology, Nanyang Technological University, 59 Nanyang Drive, Singapore 636921.; School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore., Zheng J; Shanghai Institute of Materia Medica, China Academy of Sciences, 555 Zu Chong Zhi Road, Zhang Jiang Hi-Tech Park, Pudong, Shanghai, China., Merits A; University of Tartu, Institute of Technology, Nooruse 1, 50411 Tartu, Estonia., Luo D; Lee Kong Chian School of Medicine, Nanyang Technological University, 59 Nanyang Drive, Singapore 636921.; NTU Institute of Structural Biology, Nanyang Technological University, 59 Nanyang Drive, Singapore 636921.; School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore.
Source: Nucleic acids research [Nucleic Acids Res] 2022 Jan 25; Vol. 50 (2), pp. 1000-1016.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print Cited Medium: Internet ISSN: 1362-4962 (Electronic) Linking ISSN: 03051048 NLM ISO Abbreviation: Nucleic Acids Res Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Crystal structures of alphavirus nonstructural protein 4 (nsP4) reveal an intrinsically dynamic RNA-dependent RNA polymerase fold.
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  Data: <searchLink fieldCode="AU" term="%22Tan+YB%22">Tan YB</searchLink>; Lee Kong Chian School of Medicine, Nanyang Technological University, 59 Nanyang Drive, Singapore 636921.; NTU Institute of Structural Biology, Nanyang Technological University, 59 Nanyang Drive, Singapore 636921.<br /><searchLink fieldCode="AU" term="%22Lello+LS%22">Lello LS</searchLink>; University of Tartu, Institute of Technology, Nooruse 1, 50411 Tartu, Estonia.<br /><searchLink fieldCode="AU" term="%22Liu+X%22">Liu X</searchLink>; Shanghai Institute of Materia Medica, China Academy of Sciences, 555 Zu Chong Zhi Road, Zhang Jiang Hi-Tech Park, Pudong, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Law+YS%22">Law YS</searchLink>; Lee Kong Chian School of Medicine, Nanyang Technological University, 59 Nanyang Drive, Singapore 636921.; NTU Institute of Structural Biology, Nanyang Technological University, 59 Nanyang Drive, Singapore 636921.<br /><searchLink fieldCode="AU" term="%22Kang+C%22">Kang C</searchLink>; Experimental Drug Development Centre, Agency for Science, Technology and Research (A*STAR), 10 Biopolis Rd, #05-01/06 Chromos, Singapore138670.<br /><searchLink fieldCode="AU" term="%22Lescar+J%22">Lescar J</searchLink>; NTU Institute of Structural Biology, Nanyang Technological University, 59 Nanyang Drive, Singapore 636921.; School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore.<br /><searchLink fieldCode="AU" term="%22Zheng+J%22">Zheng J</searchLink>; Shanghai Institute of Materia Medica, China Academy of Sciences, 555 Zu Chong Zhi Road, Zhang Jiang Hi-Tech Park, Pudong, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Merits+A%22">Merits A</searchLink>; University of Tartu, Institute of Technology, Nooruse 1, 50411 Tartu, Estonia.<br /><searchLink fieldCode="AU" term="%22Luo+D%22">Luo D</searchLink>; Lee Kong Chian School of Medicine, Nanyang Technological University, 59 Nanyang Drive, Singapore 636921.; NTU Institute of Structural Biology, Nanyang Technological University, 59 Nanyang Drive, Singapore 636921.; School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore.
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  Data: <searchLink fieldCode="JN" term="%220411011%22">Nucleic acids research</searchLink> [Nucleic Acids Res] 2022 Jan 25; Vol. 50 (2), pp. 1000-1016.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Oxford+University+Press%22">Oxford University Press </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>0411011 <i>Publication Model: </i>Print <i>Cited Medium: </i>Internet <i>ISSN: </i>1362-4962 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2203051048%22">03051048 </searchLink><i>NLM ISO Abbreviation: </i>Nucleic Acids Res <i>Subsets: </i>MEDLINE
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        Value: 10.1093/nar/gkab1302
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              Text: 2022 Jan 25
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