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Phase I/II trial of meclofenamate in progressive MGMT-methylated glioblastoma under temozolomide second-line therapy-the MecMeth/NOA-24 trial.

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Title: Phase I/II trial of meclofenamate in progressive MGMT-methylated glioblastoma under temozolomide second-line therapy-the MecMeth/NOA-24 trial.
Authors: Zeyen T; Division of Clinical Neurooncology, Department of Neurology and Center of Integrated Oncology, University Hospital Bonn, Bonn, Germany., Potthoff AL; Department of Neurosurgery and Center of Integrated Oncology, University Hospital Bonn, Bonn, Germany., Nemeth R; Institute of Medical Biometry, Informatics and Epidemiology, University Hospital Bonn, Bonn, Germany., Heiland DH; Department of Neurosurgery, University of Freiburg, Freiburg, Germany.; Faculty of Medicine, University of Freiburg, Freiburg, Germany., Burger MC; Dr. Senckenberg Institute of Neurooncology, Goethe-University Hospital, Frankfurt am Main, Germany., Steinbach JP; Dr. Senckenberg Institute of Neurooncology, Goethe-University Hospital, Frankfurt am Main, Germany., Hau P; Department of Neurology and Wilhelm Sander-NeuroOncology Unit, University Hospital Regensburg, Regensburg, Germany., Tabatabai G; Interdisciplinary Division of Neurooncology, University of Tübingen, Tübingen, Germany., Glas M; Division of Clinical Neurooncology, Department of Neurology, University Hospital Essen, Essen, Germany., Schlegel U; Department of Neurology, University Hospital Knappschaftskrankenhaus, Ruhr-Universität Bochum, Bochum, Germany., Grauer O; Department of Neurology, University of Münster, Münster, Germany., Krex D; Department of Neurosurgery, University of Dresden, Dresden, Germany., Schnell O; Department of Neurosurgery, University of Freiburg, Freiburg, Germany.; Faculty of Medicine, University of Freiburg, Freiburg, Germany., Goldbrunner R; Department of Neurosurgery, University of Cologne, Cologne, Germany., Sabel M; Department of Neurosurgery, University of Düsseldorf, Düsseldorf, Germany., Thon N; Department of Neurosurgery, Ludwig Maximillian University of Munich and German Cancer Consortium, Partner Site Munich, Munich, Germany., Delev D; Department of Neurosurgery, University Hospital RWTH Aachen, Aachen, Germany., Clusmann H; Department of Neurosurgery, University Hospital RWTH Aachen, Aachen, Germany., Seidel C; Department of Radiotherapy and Radiation Oncology, University of Leipzig, Leipzig, Germany., Güresir E; Department of Neurosurgery and Center of Integrated Oncology, University Hospital Bonn, Bonn, Germany., Schmid M; Institute of Medical Biometry, Informatics and Epidemiology, University Hospital Bonn, Bonn, Germany., Schuss P; Department of Neurosurgery and Center of Integrated Oncology, University Hospital Bonn, Bonn, Germany., Giordano FA; Department of Radiation Oncology, University Hospital Bonn, Bonn, Germany., Radbruch A; Department of Neuroradiology, University Hospital Bonn, Bonn, Germany., Becker A; Department of Neuropathology, University Hospital Bonn, Bonn, Germany., Weller J; Division of Clinical Neurooncology, Department of Neurology and Center of Integrated Oncology, University Hospital Bonn, Bonn, Germany., Schaub C; Division of Clinical Neurooncology, Department of Neurology and Center of Integrated Oncology, University Hospital Bonn, Bonn, Germany., Vatter H; Department of Neurosurgery and Center of Integrated Oncology, University Hospital Bonn, Bonn, Germany., Schilling J; Clinical Study Core Unit Bonn, Institute of Clinical Chemistry and Clinical Pharmacology, University Bonn, Bonn, Germany., Winkler F; Department of Neurology, University Hospital Heidelberg, Neurooncology Program at the National Center for Tumor Disease, German Cancer Consortium (DKTK), Clinical Cooperation Unit Neurooncology, German Cancer Research Center (DKFZ), Heidelberg, Germany., Herrlinger U; Division of Clinical Neurooncology, Department of Neurology and Center of Integrated Oncology, University Hospital Bonn, Bonn, Germany., Schneider M; Department of Neurosurgery and Center of Integrated Oncology, University Hospital Bonn, Bonn, Germany. matthias.schneider@ukbonn.de.
Source: Trials [Trials] 2022 Jan 19; Vol. 23 (1), pp. 57. Date of Electronic Publication: 2022 Jan 19.
Publication Type: Clinical Trial, Phase I; Clinical Trial, Phase II; Journal Article; Randomized Controlled Trial
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101263253 Publication Model: Electronic Cited Medium: Internet ISSN: 1745-6215 (Electronic) Linking ISSN: 17456215 NLM ISO Abbreviation: Trials Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Phase I/II trial of meclofenamate in progressive MGMT-methylated glioblastoma under temozolomide second-line therapy-the MecMeth/NOA-24 trial.
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  Data: <searchLink fieldCode="AU" term="%22Zeyen+T%22">Zeyen T</searchLink>; Division of Clinical Neurooncology, Department of Neurology and Center of Integrated Oncology, University Hospital Bonn, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Potthoff+AL%22">Potthoff AL</searchLink>; Department of Neurosurgery and Center of Integrated Oncology, University Hospital Bonn, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Nemeth+R%22">Nemeth R</searchLink>; Institute of Medical Biometry, Informatics and Epidemiology, University Hospital Bonn, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Heiland+DH%22">Heiland DH</searchLink>; Department of Neurosurgery, University of Freiburg, Freiburg, Germany.; Faculty of Medicine, University of Freiburg, Freiburg, Germany.<br /><searchLink fieldCode="AU" term="%22Burger+MC%22">Burger MC</searchLink>; Dr. Senckenberg Institute of Neurooncology, Goethe-University Hospital, Frankfurt am Main, Germany.<br /><searchLink fieldCode="AU" term="%22Steinbach+JP%22">Steinbach JP</searchLink>; Dr. Senckenberg Institute of Neurooncology, Goethe-University Hospital, Frankfurt am Main, Germany.<br /><searchLink fieldCode="AU" term="%22Hau+P%22">Hau P</searchLink>; Department of Neurology and Wilhelm Sander-NeuroOncology Unit, University Hospital Regensburg, Regensburg, Germany.<br /><searchLink fieldCode="AU" term="%22Tabatabai+G%22">Tabatabai G</searchLink>; Interdisciplinary Division of Neurooncology, University of Tübingen, Tübingen, Germany.<br /><searchLink fieldCode="AU" term="%22Glas+M%22">Glas M</searchLink>; Division of Clinical Neurooncology, Department of Neurology, University Hospital Essen, Essen, Germany.<br /><searchLink fieldCode="AU" term="%22Schlegel+U%22">Schlegel U</searchLink>; Department of Neurology, University Hospital Knappschaftskrankenhaus, Ruhr-Universität Bochum, Bochum, Germany.<br /><searchLink fieldCode="AU" term="%22Grauer+O%22">Grauer O</searchLink>; Department of Neurology, University of Münster, Münster, Germany.<br /><searchLink fieldCode="AU" term="%22Krex+D%22">Krex D</searchLink>; Department of Neurosurgery, University of Dresden, Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Schnell+O%22">Schnell O</searchLink>; Department of Neurosurgery, University of Freiburg, Freiburg, Germany.; Faculty of Medicine, University of Freiburg, Freiburg, Germany.<br /><searchLink fieldCode="AU" term="%22Goldbrunner+R%22">Goldbrunner R</searchLink>; Department of Neurosurgery, University of Cologne, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Sabel+M%22">Sabel M</searchLink>; Department of Neurosurgery, University of Düsseldorf, Düsseldorf, Germany.<br /><searchLink fieldCode="AU" term="%22Thon+N%22">Thon N</searchLink>; Department of Neurosurgery, Ludwig Maximillian University of Munich and German Cancer Consortium, Partner Site Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Delev+D%22">Delev D</searchLink>; Department of Neurosurgery, University Hospital RWTH Aachen, Aachen, Germany.<br /><searchLink fieldCode="AU" term="%22Clusmann+H%22">Clusmann H</searchLink>; Department of Neurosurgery, University Hospital RWTH Aachen, Aachen, Germany.<br /><searchLink fieldCode="AU" term="%22Seidel+C%22">Seidel C</searchLink>; Department of Radiotherapy and Radiation Oncology, University of Leipzig, Leipzig, Germany.<br /><searchLink fieldCode="AU" term="%22Güresir+E%22">Güresir E</searchLink>; Department of Neurosurgery and Center of Integrated Oncology, University Hospital Bonn, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Schmid+M%22">Schmid M</searchLink>; Institute of Medical Biometry, Informatics and Epidemiology, University Hospital Bonn, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Schuss+P%22">Schuss P</searchLink>; Department of Neurosurgery and Center of Integrated Oncology, University Hospital Bonn, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Giordano+FA%22">Giordano FA</searchLink>; Department of Radiation Oncology, University Hospital Bonn, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Radbruch+A%22">Radbruch A</searchLink>; Department of Neuroradiology, University Hospital Bonn, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Becker+A%22">Becker A</searchLink>; Department of Neuropathology, University Hospital Bonn, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Weller+J%22">Weller J</searchLink>; Division of Clinical Neurooncology, Department of Neurology and Center of Integrated Oncology, University Hospital Bonn, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Schaub+C%22">Schaub C</searchLink>; Division of Clinical Neurooncology, Department of Neurology and Center of Integrated Oncology, University Hospital Bonn, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Vatter+H%22">Vatter H</searchLink>; Department of Neurosurgery and Center of Integrated Oncology, University Hospital Bonn, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Schilling+J%22">Schilling J</searchLink>; Clinical Study Core Unit Bonn, Institute of Clinical Chemistry and Clinical Pharmacology, University Bonn, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Winkler+F%22">Winkler F</searchLink>; Department of Neurology, University Hospital Heidelberg, Neurooncology Program at the National Center for Tumor Disease, German Cancer Consortium (DKTK), Clinical Cooperation Unit Neurooncology, German Cancer Research Center (DKFZ), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Herrlinger+U%22">Herrlinger U</searchLink>; Division of Clinical Neurooncology, Department of Neurology and Center of Integrated Oncology, University Hospital Bonn, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Schneider+M%22">Schneider M</searchLink>; Department of Neurosurgery and Center of Integrated Oncology, University Hospital Bonn, Bonn, Germany. matthias.schneider@ukbonn.de.
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  Data: <searchLink fieldCode="JN" term="%22101263253%22">Trials</searchLink> [Trials] 2022 Jan 19; Vol. 23 (1), pp. 57. <i>Date of Electronic Publication: </i>2022 Jan 19.
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  Data: Clinical Trial, Phase I; Clinical Trial, Phase II; Journal Article; Randomized Controlled Trial
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BioMed+Central%22">BioMed Central </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101263253 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1745-6215 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2217456215%22">17456215 </searchLink><i>NLM ISO Abbreviation: </i>Trials <i>Subsets: </i>MEDLINE
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