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Absolute quantitation of individual SARS-CoV-2 RNA molecules provides a new paradigm for infection dynamics and variant differences.

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Title: Absolute quantitation of individual SARS-CoV-2 RNA molecules provides a new paradigm for infection dynamics and variant differences.
Authors: Lee JY; Department of Biochemistry, The University of Oxford, Oxford, United Kingdom., Wing PAC; Nuffield Department of Medicine, The University of Oxford, Oxford, United Kingdom.; Chinese Academy of Medical Sciences (CAMS) Oxford Institute (COI), The University of Oxford, Oxford, United Kingdom., Gala DS; Department of Biochemistry, The University of Oxford, Oxford, United Kingdom., Noerenberg M; Department of Biochemistry, The University of Oxford, Oxford, United Kingdom.; MRC-University of Glasgow Centre for Virus Research, The University of Glasgow, Glasgow, United Kingdom., Järvelin AI; Department of Biochemistry, The University of Oxford, Oxford, United Kingdom., Titlow J; Department of Biochemistry, The University of Oxford, Oxford, United Kingdom., Zhuang X; Nuffield Department of Medicine, The University of Oxford, Oxford, United Kingdom., Palmalux N; MRC-University of Glasgow Centre for Virus Research, The University of Glasgow, Glasgow, United Kingdom., Iselin L; Department of Biochemistry, The University of Oxford, Oxford, United Kingdom., Thompson MK; Department of Biochemistry, The University of Oxford, Oxford, United Kingdom., Parton RM; Department of Biochemistry, The University of Oxford, Oxford, United Kingdom., Prange-Barczynska M; Nuffield Department of Medicine, The University of Oxford, Oxford, United Kingdom.; Ludwig Institute for Cancer Research, The University of Oxford, Oxford, United Kingdom., Wainman A; Sir William Dunn School of Pathology, The University of Oxford, Oxford, United Kingdom., Salguero FJ; UK Health Security Agency, UKHSA-Porton Down, Salisbury, United Kingdom., Bishop T; Nuffield Department of Medicine, The University of Oxford, Oxford, United Kingdom.; Ludwig Institute for Cancer Research, The University of Oxford, Oxford, United Kingdom., Agranoff D; Department of Infectious Diseases, University Hospitals Sussex NHS Foundation Trust, Brighton, United Kingdom., James W; Sir William Dunn School of Pathology, The University of Oxford, Oxford, United Kingdom.; James & Lillian Martin Centre, Sir William Dunn School of Pathology, The University of Oxford, Oxford, United Kingdom., Castello A; Department of Biochemistry, The University of Oxford, Oxford, United Kingdom.; MRC-University of Glasgow Centre for Virus Research, The University of Glasgow, Glasgow, United Kingdom., McKeating JA; Nuffield Department of Medicine, The University of Oxford, Oxford, United Kingdom.; Chinese Academy of Medical Sciences (CAMS) Oxford Institute (COI), The University of Oxford, Oxford, United Kingdom., Davis I; Department of Biochemistry, The University of Oxford, Oxford, United Kingdom.
Source: ELife [Elife] 2022 Jan 20; Vol. 11. Date of Electronic Publication: 2022 Jan 20.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: eLife Sciences Publications, Ltd Country of Publication: England NLM ID: 101579614 Publication Model: Electronic Cited Medium: Internet ISSN: 2050-084X (Electronic) Linking ISSN: 2050084X NLM ISO Abbreviation: Elife Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Lee+JY%22">Lee JY</searchLink>; Department of Biochemistry, The University of Oxford, Oxford, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Wing+PAC%22">Wing PAC</searchLink>; Nuffield Department of Medicine, The University of Oxford, Oxford, United Kingdom.; Chinese Academy of Medical Sciences (CAMS) Oxford Institute (COI), The University of Oxford, Oxford, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Gala+DS%22">Gala DS</searchLink>; Department of Biochemistry, The University of Oxford, Oxford, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Noerenberg+M%22">Noerenberg M</searchLink>; Department of Biochemistry, The University of Oxford, Oxford, United Kingdom.; MRC-University of Glasgow Centre for Virus Research, The University of Glasgow, Glasgow, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Järvelin+AI%22">Järvelin AI</searchLink>; Department of Biochemistry, The University of Oxford, Oxford, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Titlow+J%22">Titlow J</searchLink>; Department of Biochemistry, The University of Oxford, Oxford, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Zhuang+X%22">Zhuang X</searchLink>; Nuffield Department of Medicine, The University of Oxford, Oxford, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Palmalux+N%22">Palmalux N</searchLink>; MRC-University of Glasgow Centre for Virus Research, The University of Glasgow, Glasgow, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Iselin+L%22">Iselin L</searchLink>; Department of Biochemistry, The University of Oxford, Oxford, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Thompson+MK%22">Thompson MK</searchLink>; Department of Biochemistry, The University of Oxford, Oxford, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Parton+RM%22">Parton RM</searchLink>; Department of Biochemistry, The University of Oxford, Oxford, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Prange-Barczynska+M%22">Prange-Barczynska M</searchLink>; Nuffield Department of Medicine, The University of Oxford, Oxford, United Kingdom.; Ludwig Institute for Cancer Research, The University of Oxford, Oxford, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Wainman+A%22">Wainman A</searchLink>; Sir William Dunn School of Pathology, The University of Oxford, Oxford, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Salguero+FJ%22">Salguero FJ</searchLink>; UK Health Security Agency, UKHSA-Porton Down, Salisbury, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Bishop+T%22">Bishop T</searchLink>; Nuffield Department of Medicine, The University of Oxford, Oxford, United Kingdom.; Ludwig Institute for Cancer Research, The University of Oxford, Oxford, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Agranoff+D%22">Agranoff D</searchLink>; Department of Infectious Diseases, University Hospitals Sussex NHS Foundation Trust, Brighton, United Kingdom.<br /><searchLink fieldCode="AU" term="%22James+W%22">James W</searchLink>; Sir William Dunn School of Pathology, The University of Oxford, Oxford, United Kingdom.; James & Lillian Martin Centre, Sir William Dunn School of Pathology, The University of Oxford, Oxford, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Castello+A%22">Castello A</searchLink>; Department of Biochemistry, The University of Oxford, Oxford, United Kingdom.; MRC-University of Glasgow Centre for Virus Research, The University of Glasgow, Glasgow, United Kingdom.<br /><searchLink fieldCode="AU" term="%22McKeating+JA%22">McKeating JA</searchLink>; Nuffield Department of Medicine, The University of Oxford, Oxford, United Kingdom.; Chinese Academy of Medical Sciences (CAMS) Oxford Institute (COI), The University of Oxford, Oxford, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Davis+I%22">Davis I</searchLink>; Department of Biochemistry, The University of Oxford, Oxford, United Kingdom.
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