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MEK inhibition overcomes chemoimmunotherapy resistance by inducing CXCL10 in cancer cells.

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Title: MEK inhibition overcomes chemoimmunotherapy resistance by inducing CXCL10 in cancer cells.
Authors: Limagne E; University of Bourgogne Franche-Comté, 21000 Dijon, France; Cancer Biology Transfer Platform, Centre Georges-François Leclerc, Equipe Labellisée Ligue Contre le Cancer, 21000 Dijon, France; Centre de Recherche INSERM LNC-UMR1231, 21000 Dijon, France; Genetic and Immunology Medical Institute, Dijon, France. Electronic address: elimagne@cgfl.fr., Nuttin L; University of Bourgogne Franche-Comté, 21000 Dijon, France; Cancer Biology Transfer Platform, Centre Georges-François Leclerc, Equipe Labellisée Ligue Contre le Cancer, 21000 Dijon, France; Centre de Recherche INSERM LNC-UMR1231, 21000 Dijon, France; Genetic and Immunology Medical Institute, Dijon, France., Thibaudin M; University of Bourgogne Franche-Comté, 21000 Dijon, France; Cancer Biology Transfer Platform, Centre Georges-François Leclerc, Equipe Labellisée Ligue Contre le Cancer, 21000 Dijon, France; Centre de Recherche INSERM LNC-UMR1231, 21000 Dijon, France; Genetic and Immunology Medical Institute, Dijon, France., Jacquin E; University of Bourgogne Franche-Comté, 21000 Dijon, France; Centre de Recherche INSERM LNC-UMR1231, 21000 Dijon, France; INSERM UMR-S 1193, Université Paris-Saclay, Châtenay-Malabry, France., Aucagne R; University of Bourgogne Franche-Comté, 21000 Dijon, France; Centre de Recherche INSERM LNC-UMR1231, 21000 Dijon, France; Genetic and Immunology Medical Institute, Dijon, France; CRISPR Innovative Genomics (CRIGEN) Platform, Unit for Innovation in Genetics and Epigenetics in Oncology (IGEO), Dijon University Hospital, 21000 Dijon, France., Bon M; University of Bourgogne Franche-Comté, 21000 Dijon, France; Cancer Biology Transfer Platform, Centre Georges-François Leclerc, Equipe Labellisée Ligue Contre le Cancer, 21000 Dijon, France; Centre de Recherche INSERM LNC-UMR1231, 21000 Dijon, France; Genetic and Immunology Medical Institute, Dijon, France., Revy S; University of Bourgogne Franche-Comté, 21000 Dijon, France; Cancer Biology Transfer Platform, Centre Georges-François Leclerc, Equipe Labellisée Ligue Contre le Cancer, 21000 Dijon, France; Centre de Recherche INSERM LNC-UMR1231, 21000 Dijon, France; Genetic and Immunology Medical Institute, Dijon, France., Barnestein R; University of Bourgogne Franche-Comté, 21000 Dijon, France; Cancer Biology Transfer Platform, Centre Georges-François Leclerc, Equipe Labellisée Ligue Contre le Cancer, 21000 Dijon, France; Centre de Recherche INSERM LNC-UMR1231, 21000 Dijon, France; Genetic and Immunology Medical Institute, Dijon, France., Ballot E; University of Bourgogne Franche-Comté, 21000 Dijon, France; Cancer Biology Transfer Platform, Centre Georges-François Leclerc, Equipe Labellisée Ligue Contre le Cancer, 21000 Dijon, France; Centre de Recherche INSERM LNC-UMR1231, 21000 Dijon, France; Genetic and Immunology Medical Institute, Dijon, France., Truntzer C; University of Bourgogne Franche-Comté, 21000 Dijon, France; Cancer Biology Transfer Platform, Centre Georges-François Leclerc, Equipe Labellisée Ligue Contre le Cancer, 21000 Dijon, France; Centre de Recherche INSERM LNC-UMR1231, 21000 Dijon, France; Genetic and Immunology Medical Institute, Dijon, France., Derangère V; University of Bourgogne Franche-Comté, 21000 Dijon, France; Cancer Biology Transfer Platform, Centre Georges-François Leclerc, Equipe Labellisée Ligue Contre le Cancer, 21000 Dijon, France; Centre de Recherche INSERM LNC-UMR1231, 21000 Dijon, France; Genetic and Immunology Medical Institute, Dijon, France., Fumet JD; University of Bourgogne Franche-Comté, 21000 Dijon, France; Department of Medical Oncology, Centre Georges-François Leclerc, 21000 Dijon, France; Cancer Biology Transfer Platform, Centre Georges-François Leclerc, Equipe Labellisée Ligue Contre le Cancer, 21000 Dijon, France; Centre de Recherche INSERM LNC-UMR1231, 21000 Dijon, France; Genetic and Immunology Medical Institute, Dijon, France., Latour C; University of Bourgogne Franche-Comté, 21000 Dijon, France; Cancer Biology Transfer Platform, Centre Georges-François Leclerc, Equipe Labellisée Ligue Contre le Cancer, 21000 Dijon, France; Centre de Recherche INSERM LNC-UMR1231, 21000 Dijon, France; Genetic and Immunology Medical Institute, Dijon, France., Rébé C; University of Bourgogne Franche-Comté, 21000 Dijon, France; Cancer Biology Transfer Platform, Centre Georges-François Leclerc, Equipe Labellisée Ligue Contre le Cancer, 21000 Dijon, France; Centre de Recherche INSERM LNC-UMR1231, 21000 Dijon, France; Genetic and Immunology Medical Institute, Dijon, France., Bellaye PS; University of Bourgogne Franche-Comté, 21000 Dijon, France; Centre de Recherche INSERM LNC-UMR1231, 21000 Dijon, France; Nuclear Medicine Unit, Preclinical Imagery and Radiotherapy Platform, Centre Georges-François Leclerc, 21000 Dijon, France., Kaderbhaï CG; Department of Medical Oncology, Centre Georges-François Leclerc, 21000 Dijon, France., Spill A; University of Bourgogne Franche-Comté, 21000 Dijon, France; Cancer Biology Transfer Platform, Centre Georges-François Leclerc, Equipe Labellisée Ligue Contre le Cancer, 21000 Dijon, France; Centre de Recherche INSERM LNC-UMR1231, 21000 Dijon, France; Genetic and Immunology Medical Institute, Dijon, France., Collin B; University of Bourgogne Franche-Comté, 21000 Dijon, France; Nuclear Medicine Unit, Preclinical Imagery and Radiotherapy Platform, Centre Georges-François Leclerc, 21000 Dijon, France; Institut de Chimie Moléculaire de l'Université; de Bourgogne, UMR CNRS 6302, 21000, Dijon, France., Callanan MB; University of Bourgogne Franche-Comté, 21000 Dijon, France; Centre de Recherche INSERM LNC-UMR1231, 21000 Dijon, France; Genetic and Immunology Medical Institute, Dijon, France; CRISPR Innovative Genomics (CRIGEN) Platform, Unit for Innovation in Genetics and Epigenetics in Oncology (IGEO), Dijon University Hospital, 21000 Dijon, France., Lagrange A; Department of Medical Oncology, Centre Georges-François Leclerc, 21000 Dijon, France., Favier L; Department of Medical Oncology, Centre Georges-François Leclerc, 21000 Dijon, France., Coudert B; Department of Medical Oncology, Centre Georges-François Leclerc, 21000 Dijon, France., Arnould L; University of Bourgogne Franche-Comté, 21000 Dijon, France; Unit of Pathology, Department of Biology and Pathology of the Tumors, Centre Georges-François Leclerc, 21000 Dijon, France., Ladoire S; University of Bourgogne Franche-Comté, 21000 Dijon, France; Department of Medical Oncology, Centre Georges-François Leclerc, 21000 Dijon, France; Cancer Biology Transfer Platform, Centre Georges-François Leclerc, Equipe Labellisée Ligue Contre le Cancer, 21000 Dijon, France; Centre de Recherche INSERM LNC-UMR1231, 21000 Dijon, France; Genetic and Immunology Medical Institute, Dijon, France., Routy B; University of Montreal Research Center (CRCHUM), Montreal, QC, Canada., Joubert P; Institut Universitaire de Cardiologie et de Pneumologie de Québec, Laval University, Quebec City, QC, Canada., Ghiringhelli F; University of Bourgogne Franche-Comté, 21000 Dijon, France; Department of Medical Oncology, Centre Georges-François Leclerc, 21000 Dijon, France; Cancer Biology Transfer Platform, Centre Georges-François Leclerc, Equipe Labellisée Ligue Contre le Cancer, 21000 Dijon, France; Centre de Recherche INSERM LNC-UMR1231, 21000 Dijon, France; Genetic and Immunology Medical Institute, Dijon, France. Electronic address: fghiringhelli@cgfl.fr.
Source: Cancer cell [Cancer Cell] 2022 Feb 14; Vol. 40 (2), pp. 136-152.e12. Date of Electronic Publication: 2022 Jan 19.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101130617 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-3686 (Electronic) Linking ISSN: 15356108 NLM ISO Abbreviation: Cancer Cell Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: MEK inhibition overcomes chemoimmunotherapy resistance by inducing CXCL10 in cancer cells.
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  Data: <searchLink fieldCode="AU" term="%22Limagne+E%22">Limagne E</searchLink>; University of Bourgogne Franche-Comté, 21000 Dijon, France; Cancer Biology Transfer Platform, Centre Georges-François Leclerc, Equipe Labellisée Ligue Contre le Cancer, 21000 Dijon, France; Centre de Recherche INSERM LNC-UMR1231, 21000 Dijon, France; Genetic and Immunology Medical Institute, Dijon, France. Electronic address: elimagne@cgfl.fr.<br /><searchLink fieldCode="AU" term="%22Nuttin+L%22">Nuttin L</searchLink>; University of Bourgogne Franche-Comté, 21000 Dijon, France; Cancer Biology Transfer Platform, Centre Georges-François Leclerc, Equipe Labellisée Ligue Contre le Cancer, 21000 Dijon, France; Centre de Recherche INSERM LNC-UMR1231, 21000 Dijon, France; Genetic and Immunology Medical Institute, Dijon, France.<br /><searchLink fieldCode="AU" term="%22Thibaudin+M%22">Thibaudin M</searchLink>; University of Bourgogne Franche-Comté, 21000 Dijon, France; Cancer Biology Transfer Platform, Centre Georges-François Leclerc, Equipe Labellisée Ligue Contre le Cancer, 21000 Dijon, France; Centre de Recherche INSERM LNC-UMR1231, 21000 Dijon, France; Genetic and Immunology Medical Institute, Dijon, France.<br /><searchLink fieldCode="AU" term="%22Jacquin+E%22">Jacquin E</searchLink>; University of Bourgogne Franche-Comté, 21000 Dijon, France; Centre de Recherche INSERM LNC-UMR1231, 21000 Dijon, France; INSERM UMR-S 1193, Université Paris-Saclay, Châtenay-Malabry, France.<br /><searchLink fieldCode="AU" term="%22Aucagne+R%22">Aucagne R</searchLink>; University of Bourgogne Franche-Comté, 21000 Dijon, France; Centre de Recherche INSERM LNC-UMR1231, 21000 Dijon, France; Genetic and Immunology Medical Institute, Dijon, France; CRISPR Innovative Genomics (CRIGEN) Platform, Unit for Innovation in Genetics and Epigenetics in Oncology (IGEO), Dijon University Hospital, 21000 Dijon, France.<br /><searchLink fieldCode="AU" term="%22Bon+M%22">Bon M</searchLink>; University of Bourgogne Franche-Comté, 21000 Dijon, France; Cancer Biology Transfer Platform, Centre Georges-François Leclerc, Equipe Labellisée Ligue Contre le Cancer, 21000 Dijon, France; Centre de Recherche INSERM LNC-UMR1231, 21000 Dijon, France; Genetic and Immunology Medical Institute, Dijon, France.<br /><searchLink fieldCode="AU" term="%22Revy+S%22">Revy S</searchLink>; University of Bourgogne Franche-Comté, 21000 Dijon, France; Cancer Biology Transfer Platform, Centre Georges-François Leclerc, Equipe Labellisée Ligue Contre le Cancer, 21000 Dijon, France; Centre de Recherche INSERM LNC-UMR1231, 21000 Dijon, France; Genetic and Immunology Medical Institute, Dijon, France.<br /><searchLink fieldCode="AU" term="%22Barnestein+R%22">Barnestein R</searchLink>; University of Bourgogne Franche-Comté, 21000 Dijon, France; Cancer Biology Transfer Platform, Centre Georges-François Leclerc, Equipe Labellisée Ligue Contre le Cancer, 21000 Dijon, France; Centre de Recherche INSERM LNC-UMR1231, 21000 Dijon, France; Genetic and Immunology Medical Institute, Dijon, France.<br /><searchLink fieldCode="AU" term="%22Ballot+E%22">Ballot E</searchLink>; University of Bourgogne Franche-Comté, 21000 Dijon, France; Cancer Biology Transfer Platform, Centre Georges-François Leclerc, Equipe Labellisée Ligue Contre le Cancer, 21000 Dijon, France; Centre de Recherche INSERM LNC-UMR1231, 21000 Dijon, France; Genetic and Immunology Medical Institute, Dijon, France.<br /><searchLink fieldCode="AU" term="%22Truntzer+C%22">Truntzer C</searchLink>; University of Bourgogne Franche-Comté, 21000 Dijon, France; Cancer Biology Transfer Platform, Centre Georges-François Leclerc, Equipe Labellisée Ligue Contre le Cancer, 21000 Dijon, France; Centre de Recherche INSERM LNC-UMR1231, 21000 Dijon, France; Genetic and Immunology Medical Institute, Dijon, France.<br /><searchLink fieldCode="AU" term="%22Derangère+V%22">Derangère V</searchLink>; University of Bourgogne Franche-Comté, 21000 Dijon, France; Cancer Biology Transfer Platform, Centre Georges-François Leclerc, Equipe Labellisée Ligue Contre le Cancer, 21000 Dijon, France; Centre de Recherche INSERM LNC-UMR1231, 21000 Dijon, France; Genetic and Immunology Medical Institute, Dijon, France.<br /><searchLink fieldCode="AU" term="%22Fumet+JD%22">Fumet JD</searchLink>; University of Bourgogne Franche-Comté, 21000 Dijon, France; Department of Medical Oncology, Centre Georges-François Leclerc, 21000 Dijon, France; Cancer Biology Transfer Platform, Centre Georges-François Leclerc, Equipe Labellisée Ligue Contre le Cancer, 21000 Dijon, France; Centre de Recherche INSERM LNC-UMR1231, 21000 Dijon, France; Genetic and Immunology Medical Institute, Dijon, France.<br /><searchLink fieldCode="AU" term="%22Latour+C%22">Latour C</searchLink>; University of Bourgogne Franche-Comté, 21000 Dijon, France; Cancer Biology Transfer Platform, Centre Georges-François Leclerc, Equipe Labellisée Ligue Contre le Cancer, 21000 Dijon, France; Centre de Recherche INSERM LNC-UMR1231, 21000 Dijon, France; Genetic and Immunology Medical Institute, Dijon, France.<br /><searchLink fieldCode="AU" term="%22Rébé+C%22">Rébé C</searchLink>; University of Bourgogne Franche-Comté, 21000 Dijon, France; Cancer Biology Transfer Platform, Centre Georges-François Leclerc, Equipe Labellisée Ligue Contre le Cancer, 21000 Dijon, France; Centre de Recherche INSERM LNC-UMR1231, 21000 Dijon, France; Genetic and Immunology Medical Institute, Dijon, France.<br /><searchLink fieldCode="AU" term="%22Bellaye+PS%22">Bellaye PS</searchLink>; University of Bourgogne Franche-Comté, 21000 Dijon, France; Centre de Recherche INSERM LNC-UMR1231, 21000 Dijon, France; Nuclear Medicine Unit, Preclinical Imagery and Radiotherapy Platform, Centre Georges-François Leclerc, 21000 Dijon, France.<br /><searchLink fieldCode="AU" term="%22Kaderbhaï+CG%22">Kaderbhaï CG</searchLink>; Department of Medical Oncology, Centre Georges-François Leclerc, 21000 Dijon, France.<br /><searchLink fieldCode="AU" term="%22Spill+A%22">Spill A</searchLink>; University of Bourgogne Franche-Comté, 21000 Dijon, France; Cancer Biology Transfer Platform, Centre Georges-François Leclerc, Equipe Labellisée Ligue Contre le Cancer, 21000 Dijon, France; Centre de Recherche INSERM LNC-UMR1231, 21000 Dijon, France; Genetic and Immunology Medical Institute, Dijon, France.<br /><searchLink fieldCode="AU" term="%22Collin+B%22">Collin B</searchLink>; University of Bourgogne Franche-Comté, 21000 Dijon, France; Nuclear Medicine Unit, Preclinical Imagery and Radiotherapy Platform, Centre Georges-François Leclerc, 21000 Dijon, France; Institut de Chimie Moléculaire de l'Université; de Bourgogne, UMR CNRS 6302, 21000, Dijon, France.<br /><searchLink fieldCode="AU" term="%22Callanan+MB%22">Callanan MB</searchLink>; University of Bourgogne Franche-Comté, 21000 Dijon, France; Centre de Recherche INSERM LNC-UMR1231, 21000 Dijon, France; Genetic and Immunology Medical Institute, Dijon, France; CRISPR Innovative Genomics (CRIGEN) Platform, Unit for Innovation in Genetics and Epigenetics in Oncology (IGEO), Dijon University Hospital, 21000 Dijon, France.<br /><searchLink fieldCode="AU" term="%22Lagrange+A%22">Lagrange A</searchLink>; Department of Medical Oncology, Centre Georges-François Leclerc, 21000 Dijon, France.<br /><searchLink fieldCode="AU" term="%22Favier+L%22">Favier L</searchLink>; Department of Medical Oncology, Centre Georges-François Leclerc, 21000 Dijon, France.<br /><searchLink fieldCode="AU" term="%22Coudert+B%22">Coudert B</searchLink>; Department of Medical Oncology, Centre Georges-François Leclerc, 21000 Dijon, France.<br /><searchLink fieldCode="AU" term="%22Arnould+L%22">Arnould L</searchLink>; University of Bourgogne Franche-Comté, 21000 Dijon, France; Unit of Pathology, Department of Biology and Pathology of the Tumors, Centre Georges-François Leclerc, 21000 Dijon, France.<br /><searchLink fieldCode="AU" term="%22Ladoire+S%22">Ladoire S</searchLink>; University of Bourgogne Franche-Comté, 21000 Dijon, France; Department of Medical Oncology, Centre Georges-François Leclerc, 21000 Dijon, France; Cancer Biology Transfer Platform, Centre Georges-François Leclerc, Equipe Labellisée Ligue Contre le Cancer, 21000 Dijon, France; Centre de Recherche INSERM LNC-UMR1231, 21000 Dijon, France; Genetic and Immunology Medical Institute, Dijon, France.<br /><searchLink fieldCode="AU" term="%22Routy+B%22">Routy B</searchLink>; University of Montreal Research Center (CRCHUM), Montreal, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Joubert+P%22">Joubert P</searchLink>; Institut Universitaire de Cardiologie et de Pneumologie de Québec, Laval University, Quebec City, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Ghiringhelli+F%22">Ghiringhelli F</searchLink>; University of Bourgogne Franche-Comté, 21000 Dijon, France; Department of Medical Oncology, Centre Georges-François Leclerc, 21000 Dijon, France; Cancer Biology Transfer Platform, Centre Georges-François Leclerc, Equipe Labellisée Ligue Contre le Cancer, 21000 Dijon, France; Centre de Recherche INSERM LNC-UMR1231, 21000 Dijon, France; Genetic and Immunology Medical Institute, Dijon, France. Electronic address: fghiringhelli@cgfl.fr.
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