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Using measures of metabolic flux to align screening and clinical development: Avoiding pitfalls to enable translational studies.

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Title: Using measures of metabolic flux to align screening and clinical development: Avoiding pitfalls to enable translational studies.
Authors: Satapati S; Merck & Co., Inc, 213 E. Grand Ave, South San Francisco, CA, 94080, USA., Downes DP; Merck & Co., Inc, 2000 Galloping Hill Rd, Kenilworth, NJ, 07033, USA., Metzger D; Merck & Co., Inc, 213 E. Grand Ave, South San Francisco, CA, 94080, USA., Shankaran H; Merck & Co., Inc, 213 E. Grand Ave, South San Francisco, CA, 94080, USA., Talukdar S; Merck & Co., Inc, 213 E. Grand Ave, South San Francisco, CA, 94080, USA., Zhou Y; Merck & Co., Inc, 213 E. Grand Ave, South San Francisco, CA, 94080, USA., Ren Z; Merck & Co., Inc, 213 E. Grand Ave, South San Francisco, CA, 94080, USA., Chen M; Merck & Co., Inc, 213 E. Grand Ave, South San Francisco, CA, 94080, USA., Lim YH; Merck & Co., Inc, 213 E. Grand Ave, South San Francisco, CA, 94080, USA., Hatcher NG; Merck & Co., Inc, 770 Sumneytown Pike, West Point, PA, 19486, USA., Wen X; Merck & Co., Inc, 2000 Galloping Hill Rd, Kenilworth, NJ, 07033, USA., Sheth PR; Merck & Co., Inc, 2000 Galloping Hill Rd, Kenilworth, NJ, 07033, USA., McLaren DG; Merck & Co., Inc, 2000 Galloping Hill Rd, Kenilworth, NJ, 07033, USA., Previs SF; Merck & Co., Inc, 2000 Galloping Hill Rd, Kenilworth, NJ, 07033, USA. Electronic address: stephen_previs@merck.com.
Source: SLAS discovery : advancing life sciences R & D [SLAS Discov] 2022 Jan; Vol. 27 (1), pp. 20-28. Date of Electronic Publication: 2021 Nov 02.
Publication Type: Journal Article
Journal Info: Publisher: SAGE Publications Country of Publication: United States NLM ID: 101697563 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2472-5560 (Electronic) Linking ISSN: 24725552 NLM ISO Abbreviation: SLAS Discov Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Using measures of metabolic flux to align screening and clinical development: Avoiding pitfalls to enable translational studies.
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  Data: <searchLink fieldCode="AU" term="%22Satapati+S%22">Satapati S</searchLink>; Merck & Co., Inc, 213 E. Grand Ave, South San Francisco, CA, 94080, USA.<br /><searchLink fieldCode="AU" term="%22Downes+DP%22">Downes DP</searchLink>; Merck & Co., Inc, 2000 Galloping Hill Rd, Kenilworth, NJ, 07033, USA.<br /><searchLink fieldCode="AU" term="%22Metzger+D%22">Metzger D</searchLink>; Merck & Co., Inc, 213 E. Grand Ave, South San Francisco, CA, 94080, USA.<br /><searchLink fieldCode="AU" term="%22Shankaran+H%22">Shankaran H</searchLink>; Merck & Co., Inc, 213 E. Grand Ave, South San Francisco, CA, 94080, USA.<br /><searchLink fieldCode="AU" term="%22Talukdar+S%22">Talukdar S</searchLink>; Merck & Co., Inc, 213 E. Grand Ave, South San Francisco, CA, 94080, USA.<br /><searchLink fieldCode="AU" term="%22Zhou+Y%22">Zhou Y</searchLink>; Merck & Co., Inc, 213 E. Grand Ave, South San Francisco, CA, 94080, USA.<br /><searchLink fieldCode="AU" term="%22Ren+Z%22">Ren Z</searchLink>; Merck & Co., Inc, 213 E. Grand Ave, South San Francisco, CA, 94080, USA.<br /><searchLink fieldCode="AU" term="%22Chen+M%22">Chen M</searchLink>; Merck & Co., Inc, 213 E. Grand Ave, South San Francisco, CA, 94080, USA.<br /><searchLink fieldCode="AU" term="%22Lim+YH%22">Lim YH</searchLink>; Merck & Co., Inc, 213 E. Grand Ave, South San Francisco, CA, 94080, USA.<br /><searchLink fieldCode="AU" term="%22Hatcher+NG%22">Hatcher NG</searchLink>; Merck & Co., Inc, 770 Sumneytown Pike, West Point, PA, 19486, USA.<br /><searchLink fieldCode="AU" term="%22Wen+X%22">Wen X</searchLink>; Merck & Co., Inc, 2000 Galloping Hill Rd, Kenilworth, NJ, 07033, USA.<br /><searchLink fieldCode="AU" term="%22Sheth+PR%22">Sheth PR</searchLink>; Merck & Co., Inc, 2000 Galloping Hill Rd, Kenilworth, NJ, 07033, USA.<br /><searchLink fieldCode="AU" term="%22McLaren+DG%22">McLaren DG</searchLink>; Merck & Co., Inc, 2000 Galloping Hill Rd, Kenilworth, NJ, 07033, USA.<br /><searchLink fieldCode="AU" term="%22Previs+SF%22">Previs SF</searchLink>; Merck & Co., Inc, 2000 Galloping Hill Rd, Kenilworth, NJ, 07033, USA. Electronic address: stephen_previs@merck.com.
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  Data: <searchLink fieldCode="JN" term="%22101697563%22">SLAS discovery : advancing life sciences R & D</searchLink> [SLAS Discov] 2022 Jan; Vol. 27 (1), pp. 20-28. <i>Date of Electronic Publication: </i>2021 Nov 02.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22SAGE+Publications%22">SAGE Publications </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101697563 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2472-5560 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2224725552%22">24725552 </searchLink><i>NLM ISO Abbreviation: </i>SLAS Discov <i>Subsets: </i>MEDLINE
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        Value: 10.1016/j.slasd.2021.10.015
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      – Code: eng
        Text: English
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        StartPage: 20
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              Text: 2022 Jan
              Type: published
              Y: 2022
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