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Using measures of metabolic flux to align screening and clinical development: Avoiding pitfalls to enable translational studies.

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Title: Using measures of metabolic flux to align screening and clinical development: Avoiding pitfalls to enable translational studies.
Authors: Satapati S; Merck & Co., Inc, 213 E. Grand Ave, South San Francisco, CA, 94080, USA., Downes DP; Merck & Co., Inc, 2000 Galloping Hill Rd, Kenilworth, NJ, 07033, USA., Metzger D; Merck & Co., Inc, 213 E. Grand Ave, South San Francisco, CA, 94080, USA., Shankaran H; Merck & Co., Inc, 213 E. Grand Ave, South San Francisco, CA, 94080, USA., Talukdar S; Merck & Co., Inc, 213 E. Grand Ave, South San Francisco, CA, 94080, USA., Zhou Y; Merck & Co., Inc, 213 E. Grand Ave, South San Francisco, CA, 94080, USA., Ren Z; Merck & Co., Inc, 213 E. Grand Ave, South San Francisco, CA, 94080, USA., Chen M; Merck & Co., Inc, 213 E. Grand Ave, South San Francisco, CA, 94080, USA., Lim YH; Merck & Co., Inc, 213 E. Grand Ave, South San Francisco, CA, 94080, USA., Hatcher NG; Merck & Co., Inc, 770 Sumneytown Pike, West Point, PA, 19486, USA., Wen X; Merck & Co., Inc, 2000 Galloping Hill Rd, Kenilworth, NJ, 07033, USA., Sheth PR; Merck & Co., Inc, 2000 Galloping Hill Rd, Kenilworth, NJ, 07033, USA., McLaren DG; Merck & Co., Inc, 2000 Galloping Hill Rd, Kenilworth, NJ, 07033, USA., Previs SF; Merck & Co., Inc, 2000 Galloping Hill Rd, Kenilworth, NJ, 07033, USA. Electronic address: stephen_previs@merck.com.
Source: SLAS discovery : advancing life sciences R & D [SLAS Discov] 2022 Jan; Vol. 27 (1), pp. 20-28. Date of Electronic Publication: 2021 Nov 02.
Publication Type: Journal Article
Journal Info: Publisher: SAGE Publications Country of Publication: United States NLM ID: 101697563 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2472-5560 (Electronic) Linking ISSN: 24725552 NLM ISO Abbreviation: SLAS Discov Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2472-5560
DOI:10.1016/j.slasd.2021.10.015