Expression of the transcription factor PU.1 induces the generation of microglia-like cells in human cortical organoids.
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| Title: | Expression of the transcription factor PU.1 induces the generation of microglia-like cells in human cortical organoids. |
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| Authors: | Cakir B; Department of Genetics, Yale Stem Cell Center, Yale School of Medicine, New Haven, CT, 06520, USA., Tanaka Y; Department of Genetics, Yale Stem Cell Center, Yale School of Medicine, New Haven, CT, 06520, USA.; Department of Medicine, Maisonneuve-Rosemont Hospital Research Centre, University of Montreal, Montreal, Quebec, H1T 2M4, Canada., Kiral FR; Department of Genetics, Yale Stem Cell Center, Yale School of Medicine, New Haven, CT, 06520, USA., Xiang Y; Department of Genetics, Yale Stem Cell Center, Yale School of Medicine, New Haven, CT, 06520, USA., Dagliyan O; Department of Neurobiology, Harvard Medical School, Boston, MA, 02115, USA., Wang J; Department of Anesthesiology, Yale School of Medicine, New Haven, CT, 06520, USA., Lee M; Department of Molecular, Cellular, Developmental Biology, Yale University, New Haven, CT, 06520, USA., Greaney AM; Department of Biomedical Engineering, Yale University, New Haven, CT, 06520, USA., Yang WS; Department of Genetics, Yale Stem Cell Center, Yale School of Medicine, New Haven, CT, 06520, USA., duBoulay C; Department of Biology, Colby College, Waterville, ME, 06901, USA., Kural MH; Department of Anesthesiology, Yale School of Medicine, New Haven, CT, 06520, USA., Patterson B; Department of Genetics, Yale Stem Cell Center, Yale School of Medicine, New Haven, CT, 06520, USA., Zhong M; Department of Cell Biology, Yale Stem Cell Center, Yale School of Medicine, New Haven, CT, 06520, USA., Kim J; Department of Genetics, Yale Stem Cell Center, Yale School of Medicine, New Haven, CT, 06520, USA., Bai Y; Department of Pathology, Yale School of Medicine, New Haven, CT, 06520, USA., Min W; Interdepartmental Program in Vascular Biology and Therapeutics, Department of Pathology, Yale School of Medicine, New Haven, CT, 06520, USA., Niklason LE; Department of Anesthesiology, Yale School of Medicine, New Haven, CT, 06520, USA.; Department of Biomedical Engineering, Yale University, New Haven, CT, 06520, USA., Patra P; Department of Genetics, Yale Stem Cell Center, Yale School of Medicine, New Haven, CT, 06520, USA.; Department of Biomedical Engineering, University of Bridgeport, Bridgeport, CT, 06604, USA., Park IH; Department of Genetics, Yale Stem Cell Center, Yale School of Medicine, New Haven, CT, 06520, USA. inhyun.park@yale.edu. |
| Source: | Nature communications [Nat Commun] 2022 Jan 20; Vol. 13 (1), pp. 430. Date of Electronic Publication: 2022 Jan 20. |
| Publication Type: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2041-1723 |
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| DOI: | 10.1038/s41467-022-28043-y |
