Single-cell multi-omics reveals dyssynchrony of the innate and adaptive immune system in progressive COVID-19.
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| Title: | Single-cell multi-omics reveals dyssynchrony of the innate and adaptive immune system in progressive COVID-19. |
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| Authors: | Unterman A; Section of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, School of Medicine, Yale University, New Haven, CT, USA. ramiu@tlvmc.gov.il.; Pulmonary Institute, Tel Aviv Sourasky Medical Center, Tel Aviv University, Tel Aviv, Israel. ramiu@tlvmc.gov.il., Sumida TS; Department of Neurology, School of Medicine, Yale University, New Haven, CT, USA. tomokazu.sumida@yale.edu.; Department of Immunobiology, School of Medicine, Yale University, New Haven, CT, USA. tomokazu.sumida@yale.edu., Nouri N; Department of Pathology, Yale School of Medicine, New Haven, CT, USA.; Center for Medical Informatics, Yale School of Medicine, New Haven, CT, USA.; The Jackson Laboratory for Genomic Medicine, Farmington, CT, USA., Yan X; Section of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, School of Medicine, Yale University, New Haven, CT, USA.; Department of Biostatistics, Yale School of Public Health, Yale University, New Haven, CT, USA., Zhao AY; Section of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, School of Medicine, Yale University, New Haven, CT, USA.; Department of Genetics, Yale School of Medicine, New Haven, CT, USA.; Department of Internal Medicine, Yale School of Medicine, New Haven, CT, USA., Gasque V; Department of Computer Science, Yale University, New Haven, CT, USA.; Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, Yale School of Medicine, New Haven, CT, USA., Schupp JC; Section of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, School of Medicine, Yale University, New Haven, CT, USA.; Department of Respiratory Medicine, Hannover Medical School and Biomedical Research in End-stage and Obstructive Lung Disease Hannover, German Lung Research Center (DZL), Hannover, Germany., Asashima H; Department of Neurology, School of Medicine, Yale University, New Haven, CT, USA.; Department of Immunobiology, School of Medicine, Yale University, New Haven, CT, USA., Liu Y; Department of Biostatistics, Yale School of Public Health, Yale University, New Haven, CT, USA., Cosme C Jr; Section of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, School of Medicine, Yale University, New Haven, CT, USA., Deng W; Department of Biostatistics, Yale School of Public Health, Yale University, New Haven, CT, USA., Chen M; Department of Biostatistics, Yale School of Public Health, Yale University, New Haven, CT, USA., Raredon MSB; Section of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, School of Medicine, Yale University, New Haven, CT, USA.; Department of Biomedical Engineering, Yale University, New Haven, CT, USA.; Medical Scientist Training Program, Yale School of Medicine, New Haven, CT, USA., Hoehn KB; Department of Pathology, Yale School of Medicine, New Haven, CT, USA., Wang G; Yale Center for Genome Analysis/Keck Biotechnology Resource Laboratory, Department of Molecular Biophysics and Biochemistry, Yale School of Medicine, New Haven, CT, USA., Wang Z; Department of Biostatistics, Yale School of Public Health, Yale University, New Haven, CT, USA., DeIuliis G; Section of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, School of Medicine, Yale University, New Haven, CT, USA., Ravindra NG; Department of Computer Science, Yale University, New Haven, CT, USA.; Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, Yale School of Medicine, New Haven, CT, USA., Li N; Department of Biostatistics, Yale School of Public Health, Yale University, New Haven, CT, USA.; SJTU-Yale Joint Center for Biostatistics and Data Science, Department of Bioinformatics and Biostatistics, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China., Castaldi C; Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA., Wong P; Department of Immunobiology, School of Medicine, Yale University, New Haven, CT, USA., Fournier J; School of Medicine, Yale University, New Haven, CT, USA., Bermejo S; Section of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, School of Medicine, Yale University, New Haven, CT, USA., Sharma L; Section of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, School of Medicine, Yale University, New Haven, CT, USA., Casanovas-Massana A; Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT, USA., Vogels CBF; Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT, USA., Wyllie AL; Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT, USA., Grubaugh ND; Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT, USA., Melillo A; Department of Pathology, Yale School of Medicine, New Haven, CT, USA., Meng H; Department of Pathology, Yale School of Medicine, New Haven, CT, USA., Stein Y; Pulmonary Institute, Tel Aviv Sourasky Medical Center, Tel Aviv University, Tel Aviv, Israel., Minasyan M; Section of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, School of Medicine, Yale University, New Haven, CT, USA., Mohanty S; Section of Infectious Diseases, Department of Internal Medicine, Yale School of Medicine, Yale University, New Haven, CT, USA., Ruff WE; Department of Neurology, School of Medicine, Yale University, New Haven, CT, USA.; Department of Immunobiology, School of Medicine, Yale University, New Haven, CT, USA., Cohen I; Department of Neurology, School of Medicine, Yale University, New Haven, CT, USA.; Department of Immunobiology, School of Medicine, Yale University, New Haven, CT, USA., Raddassi K; Department of Neurology, School of Medicine, Yale University, New Haven, CT, USA.; Department of Immunobiology, School of Medicine, Yale University, New Haven, CT, USA., Niklason LE; Departments of Anesthesiology & Biomedical Engineering, Yale University, New Haven, CT, USA., Ko AI; Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT, USA., Montgomery RR; Department of Internal Medicine, Yale School of Medicine, New Haven, CT, USA., Farhadian SF; Department of Neurology, School of Medicine, Yale University, New Haven, CT, USA.; Section of Infectious Diseases, Department of Internal Medicine, Yale School of Medicine, Yale University, New Haven, CT, USA., Iwasaki A; Department of Immunobiology, School of Medicine, Yale University, New Haven, CT, USA.; Howard Hughes Medical Institute, Chevy Chase, MD, USA., Shaw AC; Section of Infectious Diseases, Department of Internal Medicine, Yale School of Medicine, Yale University, New Haven, CT, USA., van Dijk D; Department of Computer Science, Yale University, New Haven, CT, USA.; Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, Yale School of Medicine, New Haven, CT, USA., Zhao H; Department of Biostatistics, Yale School of Public Health, Yale University, New Haven, CT, USA.; Department of Genetics, Yale School of Medicine, New Haven, CT, USA.; SJTU-Yale Joint Center for Biostatistics and Data Science, Department of Bioinformatics and Biostatistics, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China.; Inter-Departmental Program in Computational Biology and Bioinformatics, Yale University, New Haven, CT, USA., Kleinstein SH; Department of Immunobiology, School of Medicine, Yale University, New Haven, CT, USA.; Department of Pathology, Yale School of Medicine, New Haven, CT, USA.; Inter-Departmental Program in Computational Biology and Bioinformatics, Yale University, New Haven, CT, USA., Hafler DA; Department of Neurology, School of Medicine, Yale University, New Haven, CT, USA.; Department of Immunobiology, School of Medicine, Yale University, New Haven, CT, USA., Kaminski N; Section of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, School of Medicine, Yale University, New Haven, CT, USA., Dela Cruz CS; Section of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, School of Medicine, Yale University, New Haven, CT, USA.; West Haven Veterans Affair Medical Center, West Haven, CT, USA. |
| Corporate Authors: | Yale IMPACT Research Team |
| Source: | Nature communications [Nat Commun] 2022 Jan 21; Vol. 13 (1), pp. 440. Date of Electronic Publication: 2022 Jan 21. |
| Publication Type: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2041-1723 |
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| DOI: | 10.1038/s41467-021-27716-4 |
