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PI3Kδ/γ inhibition promotes human CART cell epigenetic and metabolic reprogramming to enhance antitumor cytotoxicity.

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Title: PI3Kδ/γ inhibition promotes human CART cell epigenetic and metabolic reprogramming to enhance antitumor cytotoxicity.
Authors: Funk CR; Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, GA., Wang S; Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, GA., Chen KZ; Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, GA., Waller A; Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, GA., Sharma A; Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, GA., Edgar CL; Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, GA., Gupta VA; Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, GA., Chandrakasan S; Division of Bone Marrow Transplant and., Zoine JT; Cell and Gene Therapy Program, Aflac Cancer and Blood Disorders Center, Department of Pediatrics, Children's Healthcare of Atlanta and Emory University School of Medicine, Atlanta, GA., Fedanov A; Cell and Gene Therapy Program, Aflac Cancer and Blood Disorders Center, Department of Pediatrics, Children's Healthcare of Atlanta and Emory University School of Medicine, Atlanta, GA., Raikar SS; Cell and Gene Therapy Program, Aflac Cancer and Blood Disorders Center, Department of Pediatrics, Children's Healthcare of Atlanta and Emory University School of Medicine, Atlanta, GA., Koff JL; Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, GA., Flowers CR; Cell and Gene Therapy Program, Aflac Cancer and Blood Disorders Center, Department of Pediatrics, Children's Healthcare of Atlanta and Emory University School of Medicine, Atlanta, GA.; Department of Lymphoma/Myeloma, Division of Cancer Medicine, University of Texas MD Anderson Cancer Center, Houston, TX; and., Coma S; Verastem Oncology Inc, Needham, MA., Pachter JA; Verastem Oncology Inc, Needham, MA., Ravindranathan S; Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, GA., Spencer HT; Cell and Gene Therapy Program, Aflac Cancer and Blood Disorders Center, Department of Pediatrics, Children's Healthcare of Atlanta and Emory University School of Medicine, Atlanta, GA., Shanmugam M; Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, GA., Waller EK; Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, GA.
Source: Blood [Blood] 2022 Jan 27; Vol. 139 (4), pp. 523-537.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 7603509 Publication Model: Print Cited Medium: Internet ISSN: 1528-0020 (Electronic) Linking ISSN: 00064971 NLM ISO Abbreviation: Blood Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: PI3Kδ/γ inhibition promotes human CART cell epigenetic and metabolic reprogramming to enhance antitumor cytotoxicity.
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  Data: <searchLink fieldCode="AU" term="%22Funk+CR%22">Funk CR</searchLink>; Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, GA.<br /><searchLink fieldCode="AU" term="%22Wang+S%22">Wang S</searchLink>; Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, GA.<br /><searchLink fieldCode="AU" term="%22Chen+KZ%22">Chen KZ</searchLink>; Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, GA.<br /><searchLink fieldCode="AU" term="%22Waller+A%22">Waller A</searchLink>; Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, GA.<br /><searchLink fieldCode="AU" term="%22Sharma+A%22">Sharma A</searchLink>; Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, GA.<br /><searchLink fieldCode="AU" term="%22Edgar+CL%22">Edgar CL</searchLink>; Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, GA.<br /><searchLink fieldCode="AU" term="%22Gupta+VA%22">Gupta VA</searchLink>; Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, GA.<br /><searchLink fieldCode="AU" term="%22Chandrakasan+S%22">Chandrakasan S</searchLink>; Division of Bone Marrow Transplant and.<br /><searchLink fieldCode="AU" term="%22Zoine+JT%22">Zoine JT</searchLink>; Cell and Gene Therapy Program, Aflac Cancer and Blood Disorders Center, Department of Pediatrics, Children's Healthcare of Atlanta and Emory University School of Medicine, Atlanta, GA.<br /><searchLink fieldCode="AU" term="%22Fedanov+A%22">Fedanov A</searchLink>; Cell and Gene Therapy Program, Aflac Cancer and Blood Disorders Center, Department of Pediatrics, Children's Healthcare of Atlanta and Emory University School of Medicine, Atlanta, GA.<br /><searchLink fieldCode="AU" term="%22Raikar+SS%22">Raikar SS</searchLink>; Cell and Gene Therapy Program, Aflac Cancer and Blood Disorders Center, Department of Pediatrics, Children's Healthcare of Atlanta and Emory University School of Medicine, Atlanta, GA.<br /><searchLink fieldCode="AU" term="%22Koff+JL%22">Koff JL</searchLink>; Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, GA.<br /><searchLink fieldCode="AU" term="%22Flowers+CR%22">Flowers CR</searchLink>; Cell and Gene Therapy Program, Aflac Cancer and Blood Disorders Center, Department of Pediatrics, Children's Healthcare of Atlanta and Emory University School of Medicine, Atlanta, GA.; Department of Lymphoma/Myeloma, Division of Cancer Medicine, University of Texas MD Anderson Cancer Center, Houston, TX; and.<br /><searchLink fieldCode="AU" term="%22Coma+S%22">Coma S</searchLink>; Verastem Oncology Inc, Needham, MA.<br /><searchLink fieldCode="AU" term="%22Pachter+JA%22">Pachter JA</searchLink>; Verastem Oncology Inc, Needham, MA.<br /><searchLink fieldCode="AU" term="%22Ravindranathan+S%22">Ravindranathan S</searchLink>; Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, GA.<br /><searchLink fieldCode="AU" term="%22Spencer+HT%22">Spencer HT</searchLink>; Cell and Gene Therapy Program, Aflac Cancer and Blood Disorders Center, Department of Pediatrics, Children's Healthcare of Atlanta and Emory University School of Medicine, Atlanta, GA.<br /><searchLink fieldCode="AU" term="%22Shanmugam+M%22">Shanmugam M</searchLink>; Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, GA.<br /><searchLink fieldCode="AU" term="%22Waller+EK%22">Waller EK</searchLink>; Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, GA.
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  Data: <searchLink fieldCode="JN" term="%227603509%22">Blood</searchLink> [Blood] 2022 Jan 27; Vol. 139 (4), pp. 523-537.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier%22">Elsevier </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>7603509 <i>Publication Model: </i>Print <i>Cited Medium: </i>Internet <i>ISSN: </i>1528-0020 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200064971%22">00064971 </searchLink><i>NLM ISO Abbreviation: </i>Blood <i>Subsets: </i>MEDLINE
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        Value: 10.1182/blood.2021011597
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