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Small-molecule inhibitors that disrupt the MTDH-SND1 complex suppress breast cancer progression and metastasis.

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Title: Small-molecule inhibitors that disrupt the MTDH-SND1 complex suppress breast cancer progression and metastasis.
Authors: Shen M; Department of Molecular Biology, Princeton University, Princeton, NJ, USA., Wei Y; Department of Molecular Biology, Princeton University, Princeton, NJ, USA., Kim H; Department of Chemistry, Princeton University, Princeton, NJ, USA.; Princeton University Small Molecule Screening Center, Princeton University, Princeton, NJ, USA., Wan L; Department of Molecular Biology, Princeton University, Princeton, NJ, USA., Jiang YZ; Key Laboratory of Breast Cancer in Shanghai, Department of Breast Surgery, Fudan University Shanghai Cancer Center, Shanghai, P.R. China., Hang X; Department of Molecular Biology, Princeton University, Princeton, NJ, USA., Raba M; Crelux GmgH, Martinsried, Germany., Remiszewski S; SWR Pharma Consulting LLC, Princeton, NJ, USA., Rowicki M; Department of Molecular Biology, Princeton University, Princeton, NJ, USA., Wu CG; McArdle Laboratory for Cancer Research, Department of Oncology, University of Wisconsin-Madison, School of Medicine and Public Health, Madison, WI, USA., Wu S; Key Laboratory of Breast Cancer in Shanghai, Department of Breast Surgery, Fudan University Shanghai Cancer Center, Shanghai, P.R. China., Zhang L; Department of Pathology, University Medical Center of Princeton, Plainsboro, NJ, USA.; Rutgers Cancer Institute of New Jersey, New Brunswick, NJ, USA., Lu X; Department of Molecular Biology, Princeton University, Princeton, NJ, USA., Yuan M; Department of Molecular Biology, Princeton University, Princeton, NJ, USA., Smith HA; Department of Molecular Biology, Princeton University, Princeton, NJ, USA., Zheng A; McArdle Laboratory for Cancer Research, Department of Oncology, University of Wisconsin-Madison, School of Medicine and Public Health, Madison, WI, USA., Bertino J; Pharmacokinetics and Pharmacodynamics (PK/PD) Shared Resource, Rutgers Cancer Institute of New Jersey Rutgers, The State University of New Jersey, New Brunswick, NJ, USA.; Robert Wood Johnson Medical School Rutgers, The State University of New Jersey, New Brunswick, NJ, USA., Jin JF; Firebrand Therapeutics, Princeton, NJ, USA., Xing Y; McArdle Laboratory for Cancer Research, Department of Oncology, University of Wisconsin-Madison, School of Medicine and Public Health, Madison, WI, USA., Shao ZM; Key Laboratory of Breast Cancer in Shanghai, Department of Breast Surgery, Fudan University Shanghai Cancer Center, Shanghai, P.R. China., Kang Y; Department of Molecular Biology, Princeton University, Princeton, NJ, USA. ykang@princeton.edu.; Cancer Metabolism and Growth Program, Rutgers Cancer Institute of New Jersey, New Brunswick, NJ, USA. ykang@princeton.edu.; Ludwig Institute for Cancer Research Princeton Branch, Princeton, NJ, USA. ykang@princeton.edu.
Source: Nature cancer [Nat Cancer] 2022 Jan; Vol. 3 (1), pp. 43-59. Date of Electronic Publication: 2021 Nov 29.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101761119 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2662-1347 (Electronic) Linking ISSN: 26621347 NLM ISO Abbreviation: Nat Cancer Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Small-molecule inhibitors that disrupt the MTDH-SND1 complex suppress breast cancer progression and metastasis.
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  Data: <searchLink fieldCode="AU" term="%22Shen+M%22">Shen M</searchLink>; Department of Molecular Biology, Princeton University, Princeton, NJ, USA.<br /><searchLink fieldCode="AU" term="%22Wei+Y%22">Wei Y</searchLink>; Department of Molecular Biology, Princeton University, Princeton, NJ, USA.<br /><searchLink fieldCode="AU" term="%22Kim+H%22">Kim H</searchLink>; Department of Chemistry, Princeton University, Princeton, NJ, USA.; Princeton University Small Molecule Screening Center, Princeton University, Princeton, NJ, USA.<br /><searchLink fieldCode="AU" term="%22Wan+L%22">Wan L</searchLink>; Department of Molecular Biology, Princeton University, Princeton, NJ, USA.<br /><searchLink fieldCode="AU" term="%22Jiang+YZ%22">Jiang YZ</searchLink>; Key Laboratory of Breast Cancer in Shanghai, Department of Breast Surgery, Fudan University Shanghai Cancer Center, Shanghai, P.R. China.<br /><searchLink fieldCode="AU" term="%22Hang+X%22">Hang X</searchLink>; Department of Molecular Biology, Princeton University, Princeton, NJ, USA.<br /><searchLink fieldCode="AU" term="%22Raba+M%22">Raba M</searchLink>; Crelux GmgH, Martinsried, Germany.<br /><searchLink fieldCode="AU" term="%22Remiszewski+S%22">Remiszewski S</searchLink>; SWR Pharma Consulting LLC, Princeton, NJ, USA.<br /><searchLink fieldCode="AU" term="%22Rowicki+M%22">Rowicki M</searchLink>; Department of Molecular Biology, Princeton University, Princeton, NJ, USA.<br /><searchLink fieldCode="AU" term="%22Wu+CG%22">Wu CG</searchLink>; McArdle Laboratory for Cancer Research, Department of Oncology, University of Wisconsin-Madison, School of Medicine and Public Health, Madison, WI, USA.<br /><searchLink fieldCode="AU" term="%22Wu+S%22">Wu S</searchLink>; Key Laboratory of Breast Cancer in Shanghai, Department of Breast Surgery, Fudan University Shanghai Cancer Center, Shanghai, P.R. China.<br /><searchLink fieldCode="AU" term="%22Zhang+L%22">Zhang L</searchLink>; Department of Pathology, University Medical Center of Princeton, Plainsboro, NJ, USA.; Rutgers Cancer Institute of New Jersey, New Brunswick, NJ, USA.<br /><searchLink fieldCode="AU" term="%22Lu+X%22">Lu X</searchLink>; Department of Molecular Biology, Princeton University, Princeton, NJ, USA.<br /><searchLink fieldCode="AU" term="%22Yuan+M%22">Yuan M</searchLink>; Department of Molecular Biology, Princeton University, Princeton, NJ, USA.<br /><searchLink fieldCode="AU" term="%22Smith+HA%22">Smith HA</searchLink>; Department of Molecular Biology, Princeton University, Princeton, NJ, USA.<br /><searchLink fieldCode="AU" term="%22Zheng+A%22">Zheng A</searchLink>; McArdle Laboratory for Cancer Research, Department of Oncology, University of Wisconsin-Madison, School of Medicine and Public Health, Madison, WI, USA.<br /><searchLink fieldCode="AU" term="%22Bertino+J%22">Bertino J</searchLink>; Pharmacokinetics and Pharmacodynamics (PK/PD) Shared Resource, Rutgers Cancer Institute of New Jersey Rutgers, The State University of New Jersey, New Brunswick, NJ, USA.; Robert Wood Johnson Medical School Rutgers, The State University of New Jersey, New Brunswick, NJ, USA.<br /><searchLink fieldCode="AU" term="%22Jin+JF%22">Jin JF</searchLink>; Firebrand Therapeutics, Princeton, NJ, USA.<br /><searchLink fieldCode="AU" term="%22Xing+Y%22">Xing Y</searchLink>; McArdle Laboratory for Cancer Research, Department of Oncology, University of Wisconsin-Madison, School of Medicine and Public Health, Madison, WI, USA.<br /><searchLink fieldCode="AU" term="%22Shao+ZM%22">Shao ZM</searchLink>; Key Laboratory of Breast Cancer in Shanghai, Department of Breast Surgery, Fudan University Shanghai Cancer Center, Shanghai, P.R. China.<br /><searchLink fieldCode="AU" term="%22Kang+Y%22">Kang Y</searchLink>; Department of Molecular Biology, Princeton University, Princeton, NJ, USA. ykang@princeton.edu.; Cancer Metabolism and Growth Program, Rutgers Cancer Institute of New Jersey, New Brunswick, NJ, USA. ykang@princeton.edu.; Ludwig Institute for Cancer Research Princeton Branch, Princeton, NJ, USA. ykang@princeton.edu.
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  Data: <searchLink fieldCode="JN" term="%22101761119%22">Nature cancer</searchLink> [Nat Cancer] 2022 Jan; Vol. 3 (1), pp. 43-59. <i>Date of Electronic Publication: </i>2021 Nov 29.
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