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Discovery of a Potent and Selective ATAD2 Bromodomain Inhibitor with Antiproliferative Activity in Breast Cancer Models.

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Title: Discovery of a Potent and Selective ATAD2 Bromodomain Inhibitor with Antiproliferative Activity in Breast Cancer Models.
Authors: Winter-Holt JJ, Bardelle C; BioPharmaceuticals R&D, AstraZeneca, Alderley Park, Macclesfield, Cheshire SK10 4TG, United Kingdom., Chiarparin E, Dale IL, Davey PRJ, Davies NL, Denz C; Oncology R&D, AstraZeneca, 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States., Fillery SM, Guérot CM, Han F; Pharmaron Beijing Co. Ltd., 6 Taihe Road, BDA, Beijing 100176, P. R. China., Hughes SJ, Kulkarni M; Oncology R&D, AstraZeneca, 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States., Liu Z; Pharmaron Beijing Co. Ltd., 6 Taihe Road, BDA, Beijing 100176, P. R. China., Milbradt A, Moss TA, Niu H; Pharmaron Beijing Co. Ltd., 6 Taihe Road, BDA, Beijing 100176, P. R. China., Patel J, Rabow AA, Schimpl M, Shi J; Pharmaron Beijing Co. Ltd., 6 Taihe Road, BDA, Beijing 100176, P. R. China., Sun D; Pharmaron Beijing Co. Ltd., 6 Taihe Road, BDA, Beijing 100176, P. R. China., Yang D; Pharmaron Beijing Co. Ltd., 6 Taihe Road, BDA, Beijing 100176, P. R. China., Guichard S; Oncology R&D, AstraZeneca, 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States.
Source: Journal of medicinal chemistry [J Med Chem] 2022 Feb 24; Vol. 65 (4), pp. 3306-3331. Date of Electronic Publication: 2022 Feb 08.
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Discovery of a Potent and Selective ATAD2 Bromodomain Inhibitor with Antiproliferative Activity in Breast Cancer Models.
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  Data: <searchLink fieldCode="AU" term="%22Winter-Holt+JJ%22">Winter-Holt JJ</searchLink><br /><searchLink fieldCode="AU" term="%22Bardelle+C%22">Bardelle C</searchLink>; BioPharmaceuticals R&D, AstraZeneca, Alderley Park, Macclesfield, Cheshire SK10 4TG, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Chiarparin+E%22">Chiarparin E</searchLink><br /><searchLink fieldCode="AU" term="%22Dale+IL%22">Dale IL</searchLink><br /><searchLink fieldCode="AU" term="%22Davey+PRJ%22">Davey PRJ</searchLink><br /><searchLink fieldCode="AU" term="%22Davies+NL%22">Davies NL</searchLink><br /><searchLink fieldCode="AU" term="%22Denz+C%22">Denz C</searchLink>; Oncology R&D, AstraZeneca, 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States.<br /><searchLink fieldCode="AU" term="%22Fillery+SM%22">Fillery SM</searchLink><br /><searchLink fieldCode="AU" term="%22Guérot+CM%22">Guérot CM</searchLink><br /><searchLink fieldCode="AU" term="%22Han+F%22">Han F</searchLink>; Pharmaron Beijing Co. Ltd., 6 Taihe Road, BDA, Beijing 100176, P. R. China.<br /><searchLink fieldCode="AU" term="%22Hughes+SJ%22">Hughes SJ</searchLink><br /><searchLink fieldCode="AU" term="%22Kulkarni+M%22">Kulkarni M</searchLink>; Oncology R&D, AstraZeneca, 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States.<br /><searchLink fieldCode="AU" term="%22Liu+Z%22">Liu Z</searchLink>; Pharmaron Beijing Co. Ltd., 6 Taihe Road, BDA, Beijing 100176, P. R. China.<br /><searchLink fieldCode="AU" term="%22Milbradt+A%22">Milbradt A</searchLink><br /><searchLink fieldCode="AU" term="%22Moss+TA%22">Moss TA</searchLink><br /><searchLink fieldCode="AU" term="%22Niu+H%22">Niu H</searchLink>; Pharmaron Beijing Co. Ltd., 6 Taihe Road, BDA, Beijing 100176, P. R. China.<br /><searchLink fieldCode="AU" term="%22Patel+J%22">Patel J</searchLink><br /><searchLink fieldCode="AU" term="%22Rabow+AA%22">Rabow AA</searchLink><br /><searchLink fieldCode="AU" term="%22Schimpl+M%22">Schimpl M</searchLink><br /><searchLink fieldCode="AU" term="%22Shi+J%22">Shi J</searchLink>; Pharmaron Beijing Co. Ltd., 6 Taihe Road, BDA, Beijing 100176, P. R. China.<br /><searchLink fieldCode="AU" term="%22Sun+D%22">Sun D</searchLink>; Pharmaron Beijing Co. Ltd., 6 Taihe Road, BDA, Beijing 100176, P. R. China.<br /><searchLink fieldCode="AU" term="%22Yang+D%22">Yang D</searchLink>; Pharmaron Beijing Co. Ltd., 6 Taihe Road, BDA, Beijing 100176, P. R. China.<br /><searchLink fieldCode="AU" term="%22Guichard+S%22">Guichard S</searchLink>; Oncology R&D, AstraZeneca, 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States.
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  Data: <searchLink fieldCode="JN" term="%229716531%22">Journal of medicinal chemistry</searchLink> [J Med Chem] 2022 Feb 24; Vol. 65 (4), pp. 3306-3331. <i>Date of Electronic Publication: </i>2022 Feb 08.
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