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Regional variability and genotypic and pharmacodynamic effects on PrP concentration in the CNS.

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Title: Regional variability and genotypic and pharmacodynamic effects on PrP concentration in the CNS.
Authors: Mortberg MA; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA., Zhao HT; Ionis Pharmaceuticals Inc., Carlsbad, California, USA., Reidenbach AG; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA., Gentile JE; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA., Kuhn E; Proteomics Platform, Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, Massachusetts, USA., O'Moore J; McLaughlin Research Institute, Great Falls, Montana, USA., Dooley PM; Massachusetts Alzheimer's Disease Research Center, and., Connors TR; Massachusetts Alzheimer's Disease Research Center, and., Mazur C; Ionis Pharmaceuticals Inc., Carlsbad, California, USA., Allen SW; McCance Center for Brain Health, Massachusetts General Hospital, Boston, Massachusetts, USA.; Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA., Trombetta BA; McCance Center for Brain Health, Massachusetts General Hospital, Boston, Massachusetts, USA.; Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA., McManus A; McCance Center for Brain Health, Massachusetts General Hospital, Boston, Massachusetts, USA.; Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA., Moore MR; Bioagilytix, Boston, Massachusetts, USA., Liu J; Bioagilytix, Boston, Massachusetts, USA., Cabin DE; McLaughlin Research Institute, Great Falls, Montana, USA., Kordasiewicz HB; Ionis Pharmaceuticals Inc., Carlsbad, California, USA., Mathews J; Ionis Pharmaceuticals Inc., Carlsbad, California, USA., Arnold SE; McCance Center for Brain Health, Massachusetts General Hospital, Boston, Massachusetts, USA.; Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA., Vallabh SM; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.; McCance Center for Brain Health, Massachusetts General Hospital, Boston, Massachusetts, USA.; Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.; Prion Alliance, Cambridge, Massachusetts, USA., Minikel EV; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.; McCance Center for Brain Health, Massachusetts General Hospital, Boston, Massachusetts, USA.; Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.; Prion Alliance, Cambridge, Massachusetts, USA.
Source: JCI insight [JCI Insight] 2022 Mar 22; Vol. 7 (6). Date of Electronic Publication: 2022 Mar 22.
Publication Type: Journal Article
Journal Info: Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 101676073 Publication Model: Electronic Cited Medium: Internet ISSN: 2379-3708 (Electronic) Linking ISSN: 23793708 NLM ISO Abbreviation: JCI Insight Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Mortberg+MA%22">Mortberg MA</searchLink>; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Zhao+HT%22">Zhao HT</searchLink>; Ionis Pharmaceuticals Inc., Carlsbad, California, USA.<br /><searchLink fieldCode="AU" term="%22Reidenbach+AG%22">Reidenbach AG</searchLink>; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Gentile+JE%22">Gentile JE</searchLink>; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Kuhn+E%22">Kuhn E</searchLink>; Proteomics Platform, Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22O'Moore+J%22">O'Moore J</searchLink>; McLaughlin Research Institute, Great Falls, Montana, USA.<br /><searchLink fieldCode="AU" term="%22Dooley+PM%22">Dooley PM</searchLink>; Massachusetts Alzheimer's Disease Research Center, and.<br /><searchLink fieldCode="AU" term="%22Connors+TR%22">Connors TR</searchLink>; Massachusetts Alzheimer's Disease Research Center, and.<br /><searchLink fieldCode="AU" term="%22Mazur+C%22">Mazur C</searchLink>; Ionis Pharmaceuticals Inc., Carlsbad, California, USA.<br /><searchLink fieldCode="AU" term="%22Allen+SW%22">Allen SW</searchLink>; McCance Center for Brain Health, Massachusetts General Hospital, Boston, Massachusetts, USA.; Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Trombetta+BA%22">Trombetta BA</searchLink>; McCance Center for Brain Health, Massachusetts General Hospital, Boston, Massachusetts, USA.; Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22McManus+A%22">McManus A</searchLink>; McCance Center for Brain Health, Massachusetts General Hospital, Boston, Massachusetts, USA.; Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Moore+MR%22">Moore MR</searchLink>; Bioagilytix, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Liu+J%22">Liu J</searchLink>; Bioagilytix, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Cabin+DE%22">Cabin DE</searchLink>; McLaughlin Research Institute, Great Falls, Montana, USA.<br /><searchLink fieldCode="AU" term="%22Kordasiewicz+HB%22">Kordasiewicz HB</searchLink>; Ionis Pharmaceuticals Inc., Carlsbad, California, USA.<br /><searchLink fieldCode="AU" term="%22Mathews+J%22">Mathews J</searchLink>; Ionis Pharmaceuticals Inc., Carlsbad, California, USA.<br /><searchLink fieldCode="AU" term="%22Arnold+SE%22">Arnold SE</searchLink>; McCance Center for Brain Health, Massachusetts General Hospital, Boston, Massachusetts, USA.; Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Vallabh+SM%22">Vallabh SM</searchLink>; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.; McCance Center for Brain Health, Massachusetts General Hospital, Boston, Massachusetts, USA.; Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.; Prion Alliance, Cambridge, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Minikel+EV%22">Minikel EV</searchLink>; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.; McCance Center for Brain Health, Massachusetts General Hospital, Boston, Massachusetts, USA.; Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.; Prion Alliance, Cambridge, Massachusetts, USA.
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