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Cardiomyocyte BRAF and type 1 RAF inhibitors promote cardiomyocyte and cardiac hypertrophy in mice in vivo.

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Title: Cardiomyocyte BRAF and type 1 RAF inhibitors promote cardiomyocyte and cardiac hypertrophy in mice in vivo.
Authors: Clerk A; School of Biological Sciences, University of Reading, Reading, U.K., Meijles DN; Molecular and Clinical Sciences Institute, St. George's University of London, London, U.K., Hardyman MA; School of Biological Sciences, University of Reading, Reading, U.K., Fuller SJ; School of Biological Sciences, University of Reading, Reading, U.K., Chothani SP; Program in Cardiovascular and Metabolic Disorders, Duke-National University of Singapore Medical School, Singapore City, Singapore., Cull JJ; School of Biological Sciences, University of Reading, Reading, U.K., Cooper STE; Molecular and Clinical Sciences Institute, St. George's University of London, London, U.K., Alharbi HO; School of Biological Sciences, University of Reading, Reading, U.K., Vanezis K; National Heart and Lung Institute, Imperial College London, London, U.K.; MRC London Institute of Medical Sciences, Imperial College London, London, U.K., Felkin LE; National Heart and Lung Institute, Imperial College London, London, U.K.; Cardiovascular Research Centre, Royal Brompton and Harefield Hospitals, London, U.K., Markou T; School of Biological Sciences, University of Reading, Reading, U.K., Leonard SJ; School of Biological Sciences, University of Reading, Reading, U.K., Shaw SW; School of Biological Sciences, University of Reading, Reading, U.K., Rackham OJL; Program in Cardiovascular and Metabolic Disorders, Duke-National University of Singapore Medical School, Singapore City, Singapore., Cook SA; Program in Cardiovascular and Metabolic Disorders, Duke-National University of Singapore Medical School, Singapore City, Singapore.; MRC London Institute of Medical Sciences, Imperial College London, London, U.K.; National Heart Centre Singapore, Singapore City, Singapore., Glennon PE; University Hospitals Coventry and Warwickshire, University Hospital Cardiology Department, Clifford Bridge Road, Coventry, U.K., Sheppard MN; CRY Cardiovascular Pathology Department, St. George's Healthcare NHS Trust, London, U.K., Sembrat JC; Division of Pulmonary, Allergy and Critical Care Medicine, and Dorothy P & Richard P Simmons Center for Interstitial Lung Disease, Department of Medicine, University of Pittsburgh, Pittsburgh, U.S.A., Rojas M; Division of Pulmonary, Allergy and Critical Care Medicine, and Dorothy P & Richard P Simmons Center for Interstitial Lung Disease, Department of Medicine, University of Pittsburgh, Pittsburgh, U.S.A., McTiernan CF; Heart, Lung, Blood Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, U.S.A., Barton PJ; National Heart and Lung Institute, Imperial College London, London, U.K.; Cardiovascular Research Centre, Royal Brompton and Harefield Hospitals, London, U.K., Sugden PH; School of Biological Sciences, University of Reading, Reading, U.K.
Source: The Biochemical journal [Biochem J] 2022 Feb 11; Vol. 479 (3), pp. 401-424.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Published by Portland Press on behalf of the Biochemical Society Country of Publication: England NLM ID: 2984726R Publication Model: Print Cited Medium: Internet ISSN: 1470-8728 (Electronic) Linking ISSN: 02646021 NLM ISO Abbreviation: Biochem J Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Cardiomyocyte BRAF and type 1 RAF inhibitors promote cardiomyocyte and cardiac hypertrophy in mice in vivo.
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  Data: <searchLink fieldCode="AU" term="%22Clerk+A%22">Clerk A</searchLink>; School of Biological Sciences, University of Reading, Reading, U.K.<br /><searchLink fieldCode="AU" term="%22Meijles+DN%22">Meijles DN</searchLink>; Molecular and Clinical Sciences Institute, St. George's University of London, London, U.K.<br /><searchLink fieldCode="AU" term="%22Hardyman+MA%22">Hardyman MA</searchLink>; School of Biological Sciences, University of Reading, Reading, U.K.<br /><searchLink fieldCode="AU" term="%22Fuller+SJ%22">Fuller SJ</searchLink>; School of Biological Sciences, University of Reading, Reading, U.K.<br /><searchLink fieldCode="AU" term="%22Chothani+SP%22">Chothani SP</searchLink>; Program in Cardiovascular and Metabolic Disorders, Duke-National University of Singapore Medical School, Singapore City, Singapore.<br /><searchLink fieldCode="AU" term="%22Cull+JJ%22">Cull JJ</searchLink>; School of Biological Sciences, University of Reading, Reading, U.K.<br /><searchLink fieldCode="AU" term="%22Cooper+STE%22">Cooper STE</searchLink>; Molecular and Clinical Sciences Institute, St. George's University of London, London, U.K.<br /><searchLink fieldCode="AU" term="%22Alharbi+HO%22">Alharbi HO</searchLink>; School of Biological Sciences, University of Reading, Reading, U.K.<br /><searchLink fieldCode="AU" term="%22Vanezis+K%22">Vanezis K</searchLink>; National Heart and Lung Institute, Imperial College London, London, U.K.; MRC London Institute of Medical Sciences, Imperial College London, London, U.K.<br /><searchLink fieldCode="AU" term="%22Felkin+LE%22">Felkin LE</searchLink>; National Heart and Lung Institute, Imperial College London, London, U.K.; Cardiovascular Research Centre, Royal Brompton and Harefield Hospitals, London, U.K.<br /><searchLink fieldCode="AU" term="%22Markou+T%22">Markou T</searchLink>; School of Biological Sciences, University of Reading, Reading, U.K.<br /><searchLink fieldCode="AU" term="%22Leonard+SJ%22">Leonard SJ</searchLink>; School of Biological Sciences, University of Reading, Reading, U.K.<br /><searchLink fieldCode="AU" term="%22Shaw+SW%22">Shaw SW</searchLink>; School of Biological Sciences, University of Reading, Reading, U.K.<br /><searchLink fieldCode="AU" term="%22Rackham+OJL%22">Rackham OJL</searchLink>; Program in Cardiovascular and Metabolic Disorders, Duke-National University of Singapore Medical School, Singapore City, Singapore.<br /><searchLink fieldCode="AU" term="%22Cook+SA%22">Cook SA</searchLink>; Program in Cardiovascular and Metabolic Disorders, Duke-National University of Singapore Medical School, Singapore City, Singapore.; MRC London Institute of Medical Sciences, Imperial College London, London, U.K.; National Heart Centre Singapore, Singapore City, Singapore.<br /><searchLink fieldCode="AU" term="%22Glennon+PE%22">Glennon PE</searchLink>; University Hospitals Coventry and Warwickshire, University Hospital Cardiology Department, Clifford Bridge Road, Coventry, U.K.<br /><searchLink fieldCode="AU" term="%22Sheppard+MN%22">Sheppard MN</searchLink>; CRY Cardiovascular Pathology Department, St. George's Healthcare NHS Trust, London, U.K.<br /><searchLink fieldCode="AU" term="%22Sembrat+JC%22">Sembrat JC</searchLink>; Division of Pulmonary, Allergy and Critical Care Medicine, and Dorothy P & Richard P Simmons Center for Interstitial Lung Disease, Department of Medicine, University of Pittsburgh, Pittsburgh, U.S.A.<br /><searchLink fieldCode="AU" term="%22Rojas+M%22">Rojas M</searchLink>; Division of Pulmonary, Allergy and Critical Care Medicine, and Dorothy P & Richard P Simmons Center for Interstitial Lung Disease, Department of Medicine, University of Pittsburgh, Pittsburgh, U.S.A.<br /><searchLink fieldCode="AU" term="%22McTiernan+CF%22">McTiernan CF</searchLink>; Heart, Lung, Blood Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, U.S.A.<br /><searchLink fieldCode="AU" term="%22Barton+PJ%22">Barton PJ</searchLink>; National Heart and Lung Institute, Imperial College London, London, U.K.; Cardiovascular Research Centre, Royal Brompton and Harefield Hospitals, London, U.K.<br /><searchLink fieldCode="AU" term="%22Sugden+PH%22">Sugden PH</searchLink>; School of Biological Sciences, University of Reading, Reading, U.K.
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  Data: <searchLink fieldCode="JN" term="%222984726R%22">The Biochemical journal</searchLink> [Biochem J] 2022 Feb 11; Vol. 479 (3), pp. 401-424.
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        Value: 10.1042/BCJ20210615
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