Identification of novel HPFH-like mutations by CRISPR base editing that elevate the expression of fetal hemoglobin.
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| Title: | Identification of novel HPFH-like mutations by CRISPR base editing that elevate the expression of fetal hemoglobin. |
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| Authors: | Ravi NS; Centre for Stem Cell Research (a Unit of inStem, Bengaluru), Christian Medical College Campus, Vellore, India.; Sree Chitra Tirunal Institute for Medical Sciences and Technology, Thiruvananthapuram, India., Wienert B; Innovative Genomics Institute, University of California, Berkeley, Berkeley, United States.; Institute of Data Science and Biotechnology, Gladstone Institutes, San Francisco, United States.; School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, Australia., Wyman SK; Innovative Genomics Institute, University of California, Berkeley, Berkeley, United States., Bell HW; School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, Australia., George A; Centre for Stem Cell Research (a Unit of inStem, Bengaluru), Christian Medical College Campus, Vellore, India.; Sree Chitra Tirunal Institute for Medical Sciences and Technology, Thiruvananthapuram, India., Mahalingam G; Centre for Stem Cell Research (a Unit of inStem, Bengaluru), Christian Medical College Campus, Vellore, India., Vu JT; Innovative Genomics Institute, University of California, Berkeley, Berkeley, United States., Prasad K; Centre for Stem Cell Research (a Unit of inStem, Bengaluru), Christian Medical College Campus, Vellore, India.; Manipal Academy of Higher Education, Karnataka, India., Bandlamudi BP; Centre for Stem Cell Research (a Unit of inStem, Bengaluru), Christian Medical College Campus, Vellore, India., Devaraju N; Centre for Stem Cell Research (a Unit of inStem, Bengaluru), Christian Medical College Campus, Vellore, India.; Manipal Academy of Higher Education, Karnataka, India., Rajendiran V; Centre for Stem Cell Research (a Unit of inStem, Bengaluru), Christian Medical College Campus, Vellore, India.; Sree Chitra Tirunal Institute for Medical Sciences and Technology, Thiruvananthapuram, India., Syedbasha N; Centre for Stem Cell Research (a Unit of inStem, Bengaluru), Christian Medical College Campus, Vellore, India., Pai AA; Sree Chitra Tirunal Institute for Medical Sciences and Technology, Thiruvananthapuram, India.; Department of Haematology, Christian Medical College & Hospital, Vellore, India., Nakamura Y; Cell Engineering Division, RIKEN BioResource Center, Ibaraki, Japan., Kurita R; Research and Development Department, Central Blood Institute Blood Service Headquarters, Japanese Red Cross Society, Japan, Tokyo, Japan., Narayanasamy M; Centre for Stem Cell Research (a Unit of inStem, Bengaluru), Christian Medical College Campus, Vellore, India.; Department of Biochemistry, Christian Medical College, Vellore, India., Balasubramanian P; Sree Chitra Tirunal Institute for Medical Sciences and Technology, Thiruvananthapuram, India.; Department of Haematology, Christian Medical College & Hospital, Vellore, India., Thangavel S; Centre for Stem Cell Research (a Unit of inStem, Bengaluru), Christian Medical College Campus, Vellore, India., Marepally S; Centre for Stem Cell Research (a Unit of inStem, Bengaluru), Christian Medical College Campus, Vellore, India., Velayudhan SR; Centre for Stem Cell Research (a Unit of inStem, Bengaluru), Christian Medical College Campus, Vellore, India.; Sree Chitra Tirunal Institute for Medical Sciences and Technology, Thiruvananthapuram, India.; Department of Haematology, Christian Medical College & Hospital, Vellore, India., Srivastava A; Centre for Stem Cell Research (a Unit of inStem, Bengaluru), Christian Medical College Campus, Vellore, India.; Sree Chitra Tirunal Institute for Medical Sciences and Technology, Thiruvananthapuram, India.; Department of Haematology, Christian Medical College & Hospital, Vellore, India., DeWitt MA; Innovative Genomics Institute, University of California, Berkeley, Berkeley, United States.; Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, Los Angeles, United States., Crossley M; School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, Australia., Corn JE; Innovative Genomics Institute, University of California, Berkeley, Berkeley, United States.; Institute of Molecular Health Sciences, Department of Biology, Zurich, Switzerland., Mohankumar KM; Centre for Stem Cell Research (a Unit of inStem, Bengaluru), Christian Medical College Campus, Vellore, India.; Sree Chitra Tirunal Institute for Medical Sciences and Technology, Thiruvananthapuram, India. |
| Source: | ELife [Elife] 2022 Feb 11; Vol. 11. Date of Electronic Publication: 2022 Feb 11. |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: eLife Sciences Publications, Ltd Country of Publication: England NLM ID: 101579614 Publication Model: Electronic Cited Medium: Internet ISSN: 2050-084X (Electronic) Linking ISSN: 2050084X NLM ISO Abbreviation: Elife Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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