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Inhibition of carnitine palmitoyltransferase 1A in hepatic stellate cells protects against fibrosis.

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Title: Inhibition of carnitine palmitoyltransferase 1A in hepatic stellate cells protects against fibrosis.
Authors: Fondevila MF; Department of Physiology, CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, Spain; CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, Spain. Electronic address: marcos.fernandez.fondevila@gmail.com., Fernandez U; Department of Physiology, CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, Spain; CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, Spain., Heras V; Department of Physiology, CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, Spain., Parracho T; Department of Physiology, CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, Spain., Gonzalez-Rellan MJ; Department of Physiology, CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, Spain., Novoa E; Department of Physiology, CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, Spain., Porteiro B; Department of Physiology, CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, Spain., Alonso C; OWL Metabolomics, Technology Park of Bizkaia, Derio, Bizkaia, Spain., Mayo R; OWL Metabolomics, Technology Park of Bizkaia, Derio, Bizkaia, Spain., da Silva Lima N; Department of Physiology, CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, Spain., Iglesias C; Department of Physiology, CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, Spain., Filliol AA; Department of Medicine, Columbia University, New York, NY, USA., Senra A; Department of Physiology, CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, Spain., Delgado TC; Liver Disease Lab, Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), 48160 Derio, Bizkaia, Spain; CIBER Enfermedades Hepáticas y Digestivas (CIBERehd), Spain., Woodhoo A; Gene Regulatory Control in Disease, CIMUS, University of Santiago de Compostela, Santiago de Compostela, Spain., Herrero L; CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, Spain; Department of Biochemistry and Physiology, School of Pharmacy and Food Sciences, Institut de Biomedicina de la Universitat de Barcelona (IBUB), Barcelona, Spain., Serra D; CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, Spain; Department of Biochemistry and Physiology, School of Pharmacy and Food Sciences, Institut de Biomedicina de la Universitat de Barcelona (IBUB), Barcelona, Spain., Prevot V; Univ. Lille, Inserm, CHU Lille, Laboratory of Development and Plasticity of the Neuroendocrine Brain, Lille Neuroscience & Cognition, UMR-S 1172, European Genomic Institute for Diabetes (EGID), F-59000 Lille, France., Schwaninger M; University of Lübeck, Institute for Experimental and Clinical Pharmacology and Toxicology, Lübeck, Germany., López M; Department of Physiology, CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, Spain; CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, Spain., Dieguez C; Department of Physiology, CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, Spain; CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, Spain., Millet O; OWL Metabolomics, Technology Park of Bizkaia, Derio, Bizkaia, Spain; Liver Disease Lab, Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), 48160 Derio, Bizkaia, Spain., Mato JM; OWL Metabolomics, Technology Park of Bizkaia, Derio, Bizkaia, Spain; Liver Disease Lab, Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), 48160 Derio, Bizkaia, Spain., Cubero FJ; Department of Immunology, Ophthalmology & ENT, Complutense University School of Medicine, 28040 Madrid, Spain; Health Research Institute Gregorio Marañón (IiSGM), 28007 Madrid, Spain., Varela-Rey M; Gene Regulatory Control in Disease, CIMUS, University of Santiago de Compostela, Santiago de Compostela, Spain., Iruzubieta P; Gastroenterology and Hepatology Department, Marqués de Valdecilla University Hospital. Clinical and Translational Digestive Research Group, IDIVAL, Santander, Spain., Crespo J; Gastroenterology and Hepatology Department, Marqués de Valdecilla University Hospital. Clinical and Translational Digestive Research Group, IDIVAL, Santander, Spain., Martinez-Chantar ML; Liver Disease Lab, Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), 48160 Derio, Bizkaia, Spain; CIBER Enfermedades Hepáticas y Digestivas (CIBERehd), Spain., Schwabe RF; Department of Medicine, Columbia University, New York, NY, USA., Nogueiras R; Department of Physiology, CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, Spain; CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, Spain; Galician Agency of Innovation (GAIN), Xunta de Galicia, Santiago de Compostela, Spain. Electronic address: ruben.nogueiras@usc.es.
Source: Journal of hepatology [J Hepatol] 2022 Jul; Vol. 77 (1), pp. 15-28. Date of Electronic Publication: 2022 Feb 12.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 8503886 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1600-0641 (Electronic) Linking ISSN: 01688278 NLM ISO Abbreviation: J Hepatol Subsets: MEDLINE
Database: MEDLINE Ultimate
FullText Text:
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  Data: Inhibition of carnitine palmitoyltransferase 1A in hepatic stellate cells protects against fibrosis.
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  Data: <searchLink fieldCode="AU" term="%22Fondevila+MF%22">Fondevila MF</searchLink>; Department of Physiology, CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, Spain; CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, Spain. Electronic address: marcos.fernandez.fondevila@gmail.com.<br /><searchLink fieldCode="AU" term="%22Fernandez+U%22">Fernandez U</searchLink>; Department of Physiology, CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, Spain; CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, Spain.<br /><searchLink fieldCode="AU" term="%22Heras+V%22">Heras V</searchLink>; Department of Physiology, CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, Spain.<br /><searchLink fieldCode="AU" term="%22Parracho+T%22">Parracho T</searchLink>; Department of Physiology, CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, Spain.<br /><searchLink fieldCode="AU" term="%22Gonzalez-Rellan+MJ%22">Gonzalez-Rellan MJ</searchLink>; Department of Physiology, CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, Spain.<br /><searchLink fieldCode="AU" term="%22Novoa+E%22">Novoa E</searchLink>; Department of Physiology, CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, Spain.<br /><searchLink fieldCode="AU" term="%22Porteiro+B%22">Porteiro B</searchLink>; Department of Physiology, CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, Spain.<br /><searchLink fieldCode="AU" term="%22Alonso+C%22">Alonso C</searchLink>; OWL Metabolomics, Technology Park of Bizkaia, Derio, Bizkaia, Spain.<br /><searchLink fieldCode="AU" term="%22Mayo+R%22">Mayo R</searchLink>; OWL Metabolomics, Technology Park of Bizkaia, Derio, Bizkaia, Spain.<br /><searchLink fieldCode="AU" term="%22da+Silva+Lima+N%22">da Silva Lima N</searchLink>; Department of Physiology, CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, Spain.<br /><searchLink fieldCode="AU" term="%22Iglesias+C%22">Iglesias C</searchLink>; Department of Physiology, CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, Spain.<br /><searchLink fieldCode="AU" term="%22Filliol+AA%22">Filliol AA</searchLink>; Department of Medicine, Columbia University, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Senra+A%22">Senra A</searchLink>; Department of Physiology, CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, Spain.<br /><searchLink fieldCode="AU" term="%22Delgado+TC%22">Delgado TC</searchLink>; Liver Disease Lab, Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), 48160 Derio, Bizkaia, Spain; CIBER Enfermedades Hepáticas y Digestivas (CIBERehd), Spain.<br /><searchLink fieldCode="AU" term="%22Woodhoo+A%22">Woodhoo A</searchLink>; Gene Regulatory Control in Disease, CIMUS, University of Santiago de Compostela, Santiago de Compostela, Spain.<br /><searchLink fieldCode="AU" term="%22Herrero+L%22">Herrero L</searchLink>; CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, Spain; Department of Biochemistry and Physiology, School of Pharmacy and Food Sciences, Institut de Biomedicina de la Universitat de Barcelona (IBUB), Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Serra+D%22">Serra D</searchLink>; CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, Spain; Department of Biochemistry and Physiology, School of Pharmacy and Food Sciences, Institut de Biomedicina de la Universitat de Barcelona (IBUB), Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Prevot+V%22">Prevot V</searchLink>; Univ. Lille, Inserm, CHU Lille, Laboratory of Development and Plasticity of the Neuroendocrine Brain, Lille Neuroscience & Cognition, UMR-S 1172, European Genomic Institute for Diabetes (EGID), F-59000 Lille, France.<br /><searchLink fieldCode="AU" term="%22Schwaninger+M%22">Schwaninger M</searchLink>; University of Lübeck, Institute for Experimental and Clinical Pharmacology and Toxicology, Lübeck, Germany.<br /><searchLink fieldCode="AU" term="%22López+M%22">López M</searchLink>; Department of Physiology, CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, Spain; CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, Spain.<br /><searchLink fieldCode="AU" term="%22Dieguez+C%22">Dieguez C</searchLink>; Department of Physiology, CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, Spain; CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, Spain.<br /><searchLink fieldCode="AU" term="%22Millet+O%22">Millet O</searchLink>; OWL Metabolomics, Technology Park of Bizkaia, Derio, Bizkaia, Spain; Liver Disease Lab, Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), 48160 Derio, Bizkaia, Spain.<br /><searchLink fieldCode="AU" term="%22Mato+JM%22">Mato JM</searchLink>; OWL Metabolomics, Technology Park of Bizkaia, Derio, Bizkaia, Spain; Liver Disease Lab, Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), 48160 Derio, Bizkaia, Spain.<br /><searchLink fieldCode="AU" term="%22Cubero+FJ%22">Cubero FJ</searchLink>; Department of Immunology, Ophthalmology & ENT, Complutense University School of Medicine, 28040 Madrid, Spain; Health Research Institute Gregorio Marañón (IiSGM), 28007 Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Varela-Rey+M%22">Varela-Rey M</searchLink>; Gene Regulatory Control in Disease, CIMUS, University of Santiago de Compostela, Santiago de Compostela, Spain.<br /><searchLink fieldCode="AU" term="%22Iruzubieta+P%22">Iruzubieta P</searchLink>; Gastroenterology and Hepatology Department, Marqués de Valdecilla University Hospital. Clinical and Translational Digestive Research Group, IDIVAL, Santander, Spain.<br /><searchLink fieldCode="AU" term="%22Crespo+J%22">Crespo J</searchLink>; Gastroenterology and Hepatology Department, Marqués de Valdecilla University Hospital. Clinical and Translational Digestive Research Group, IDIVAL, Santander, Spain.<br /><searchLink fieldCode="AU" term="%22Martinez-Chantar+ML%22">Martinez-Chantar ML</searchLink>; Liver Disease Lab, Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), 48160 Derio, Bizkaia, Spain; CIBER Enfermedades Hepáticas y Digestivas (CIBERehd), Spain.<br /><searchLink fieldCode="AU" term="%22Schwabe+RF%22">Schwabe RF</searchLink>; Department of Medicine, Columbia University, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Nogueiras+R%22">Nogueiras R</searchLink>; Department of Physiology, CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, Spain; CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, Spain; Galician Agency of Innovation (GAIN), Xunta de Galicia, Santiago de Compostela, Spain. Electronic address: ruben.nogueiras@usc.es.
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