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Natural and Designed Proteins Inspired by Extremotolerant Organisms Can Form Condensates and Attenuate Apoptosis in Human Cells.

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Title: Natural and Designed Proteins Inspired by Extremotolerant Organisms Can Form Condensates and Attenuate Apoptosis in Human Cells.
Authors: Veling MT; Department of Systems Biology, Harvard Medical School, Boston, Massachusetts 02115, United States.; Wyss Institute for Biologically Inspired Engineering, Boston, Massachusetts 02115, United States., Nguyen DT; Department of Systems Biology, Harvard Medical School, Boston, Massachusetts 02115, United States.; Wyss Institute for Biologically Inspired Engineering, Boston, Massachusetts 02115, United States., Thadani NN; Department of Systems Biology, Harvard Medical School, Boston, Massachusetts 02115, United States., Oster ME; Department of Systems Biology, Harvard Medical School, Boston, Massachusetts 02115, United States.; Wyss Institute for Biologically Inspired Engineering, Boston, Massachusetts 02115, United States., Rollins NJ; Department of Systems Biology, Harvard Medical School, Boston, Massachusetts 02115, United States.; Wyss Institute for Biologically Inspired Engineering, Boston, Massachusetts 02115, United States., Brock KP; Department of Systems Biology, Harvard Medical School, Boston, Massachusetts 02115, United States., Bethel NP; Institute for Protein Design, University of Washington, Seattle, Washington 98195, United States.; Department of Biochemistry, University of Washington, Seattle, Washington 98195, United States., Lim S; Department of Systems Biology, Harvard Medical School, Boston, Massachusetts 02115, United States.; Wyss Institute for Biologically Inspired Engineering, Boston, Massachusetts 02115, United States., Baker D; Institute for Protein Design, University of Washington, Seattle, Washington 98195, United States.; Department of Biochemistry, University of Washington, Seattle, Washington 98195, United States.; Howard Hughes Medical Institute, University of Washington, Seattle, Washington 98195, United States., Way JC; Department of Systems Biology, Harvard Medical School, Boston, Massachusetts 02115, United States.; Wyss Institute for Biologically Inspired Engineering, Boston, Massachusetts 02115, United States., Marks DS; Department of Systems Biology, Harvard Medical School, Boston, Massachusetts 02115, United States.; Broad Institute of Harvard and MIT, Cambridge, Massachusetts 02142, United States., Chang RL; Department of Systems Biology, Harvard Medical School, Boston, Massachusetts 02115, United States.; Wyss Institute for Biologically Inspired Engineering, Boston, Massachusetts 02115, United States.; Department of Systems & Computational Biology, Albert Einstein College of Medicine, Bronx, New York 10461, United States., Silver PA; Department of Systems Biology, Harvard Medical School, Boston, Massachusetts 02115, United States.; Wyss Institute for Biologically Inspired Engineering, Boston, Massachusetts 02115, United States.
Source: ACS synthetic biology [ACS Synth Biol] 2022 Mar 18; Vol. 11 (3), pp. 1292-1302. Date of Electronic Publication: 2022 Feb 18.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101575075 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2161-5063 (Electronic) Linking ISSN: 21615063 NLM ISO Abbreviation: ACS Synth Biol Subsets: MEDLINE
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  Data: Natural and Designed Proteins Inspired by Extremotolerant Organisms Can Form Condensates and Attenuate Apoptosis in Human Cells.
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  Data: <searchLink fieldCode="AU" term="%22Veling+MT%22">Veling MT</searchLink>; Department of Systems Biology, Harvard Medical School, Boston, Massachusetts 02115, United States.; Wyss Institute for Biologically Inspired Engineering, Boston, Massachusetts 02115, United States.<br /><searchLink fieldCode="AU" term="%22Nguyen+DT%22">Nguyen DT</searchLink>; Department of Systems Biology, Harvard Medical School, Boston, Massachusetts 02115, United States.; Wyss Institute for Biologically Inspired Engineering, Boston, Massachusetts 02115, United States.<br /><searchLink fieldCode="AU" term="%22Thadani+NN%22">Thadani NN</searchLink>; Department of Systems Biology, Harvard Medical School, Boston, Massachusetts 02115, United States.<br /><searchLink fieldCode="AU" term="%22Oster+ME%22">Oster ME</searchLink>; Department of Systems Biology, Harvard Medical School, Boston, Massachusetts 02115, United States.; Wyss Institute for Biologically Inspired Engineering, Boston, Massachusetts 02115, United States.<br /><searchLink fieldCode="AU" term="%22Rollins+NJ%22">Rollins NJ</searchLink>; Department of Systems Biology, Harvard Medical School, Boston, Massachusetts 02115, United States.; Wyss Institute for Biologically Inspired Engineering, Boston, Massachusetts 02115, United States.<br /><searchLink fieldCode="AU" term="%22Brock+KP%22">Brock KP</searchLink>; Department of Systems Biology, Harvard Medical School, Boston, Massachusetts 02115, United States.<br /><searchLink fieldCode="AU" term="%22Bethel+NP%22">Bethel NP</searchLink>; Institute for Protein Design, University of Washington, Seattle, Washington 98195, United States.; Department of Biochemistry, University of Washington, Seattle, Washington 98195, United States.<br /><searchLink fieldCode="AU" term="%22Lim+S%22">Lim S</searchLink>; Department of Systems Biology, Harvard Medical School, Boston, Massachusetts 02115, United States.; Wyss Institute for Biologically Inspired Engineering, Boston, Massachusetts 02115, United States.<br /><searchLink fieldCode="AU" term="%22Baker+D%22">Baker D</searchLink>; Institute for Protein Design, University of Washington, Seattle, Washington 98195, United States.; Department of Biochemistry, University of Washington, Seattle, Washington 98195, United States.; Howard Hughes Medical Institute, University of Washington, Seattle, Washington 98195, United States.<br /><searchLink fieldCode="AU" term="%22Way+JC%22">Way JC</searchLink>; Department of Systems Biology, Harvard Medical School, Boston, Massachusetts 02115, United States.; Wyss Institute for Biologically Inspired Engineering, Boston, Massachusetts 02115, United States.<br /><searchLink fieldCode="AU" term="%22Marks+DS%22">Marks DS</searchLink>; Department of Systems Biology, Harvard Medical School, Boston, Massachusetts 02115, United States.; Broad Institute of Harvard and MIT, Cambridge, Massachusetts 02142, United States.<br /><searchLink fieldCode="AU" term="%22Chang+RL%22">Chang RL</searchLink>; Department of Systems Biology, Harvard Medical School, Boston, Massachusetts 02115, United States.; Wyss Institute for Biologically Inspired Engineering, Boston, Massachusetts 02115, United States.; Department of Systems & Computational Biology, Albert Einstein College of Medicine, Bronx, New York 10461, United States.<br /><searchLink fieldCode="AU" term="%22Silver+PA%22">Silver PA</searchLink>; Department of Systems Biology, Harvard Medical School, Boston, Massachusetts 02115, United States.; Wyss Institute for Biologically Inspired Engineering, Boston, Massachusetts 02115, United States.
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