Immunopathological signatures in multisystem inflammatory syndrome in children and pediatric COVID-19.

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Title: Immunopathological signatures in multisystem inflammatory syndrome in children and pediatric COVID-19.
Authors: Sacco K; Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Castagnoli R; Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.; Pediatric Clinic, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy; Department of Clinical, Surgical, Diagnostic and Pediatric Sciences, University of Pavia, Pavia, Italy., Vakkilainen S; Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Liu C; Multiscale Systems Biology Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.; Graduate Program in Biological Sciences, University of Maryland, College Park, MD, USA., Delmonte OM; Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Oguz C; NIAID Collaborative Bioinformatics Resource (NCBR), National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.; Advanced Biomedical Computational Science, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc, Frederick, MD, USA., Kaplan IM; Adaptive Biotechnologies, Seattle, WA, USA., Alehashemi S; Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Burbelo PD; National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA., Bhuyan F; Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., de Jesus AA; Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Dobbs K; Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Rosen LB; Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Cheng A; Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Shaw E; Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Vakkilainen MS; Department of Computer Science, Aalto University, Helsinki, Finland., Pala F; Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Lack J; Multiscale Systems Biology Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.; NIAID Collaborative Bioinformatics Resource (NCBR), National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Zhang Y; Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Fink DL; Applied/Developmental Research Directorate, Frederick National Laboratory for Cancer Research, Frederick, MD, USA., Oikonomou V; Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Snow AL; Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA., Dalgard CL; Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.; The American Genome Center, Uniformed Services University of the Health Sciences, Bethesda, MD, USA., Chen J; Trans-NIH Center for Human Immunology, Autoimmunity, and Inflammation (CHI), National Institutes of Health, Bethesda, MD, USA., Sellers BA; Trans-NIH Center for Human Immunology, Autoimmunity, and Inflammation (CHI), National Institutes of Health, Bethesda, MD, USA., Montealegre Sanchez GA; Intramural Clinical Management and Operation Branch (ICMOB), Division of Clinical Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Barron K; Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Rey-Jurado E; Facultad de Medicina Clínica Alemana Universidad del Desarrollo, Santiago, Chile., Vial C; Facultad de Medicina Clínica Alemana Universidad del Desarrollo, Santiago, Chile., Poli MC; Facultad de Medicina Clínica Alemana Universidad del Desarrollo, Santiago, Chile.; Unidad de Inmunología y Reumatología, Hospital de niños Dr. Roberto del Río, Santiago, Chile., Licari A; Pediatric Clinic, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy; Department of Clinical, Surgical, Diagnostic and Pediatric Sciences, University of Pavia, Pavia, Italy., Montagna D; Pediatric Clinic, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy; Department of Clinical, Surgical, Diagnostic and Pediatric Sciences, University of Pavia, Pavia, Italy.; Laboratory of Immunology and Transplantation, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy., Marseglia GL; Pediatric Clinic, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy; Department of Clinical, Surgical, Diagnostic and Pediatric Sciences, University of Pavia, Pavia, Italy., Licciardi F; Department of Pediatric and Public Health Sciences, Regina Margherita Children's Hospital, A.O.U. Città Della Salute E Della Scienza Di Torino, University of Turin, Turin, Italy., Ramenghi U; Department of Pediatric and Public Health Sciences, Regina Margherita Children's Hospital, A.O.U. Città Della Salute E Della Scienza Di Torino, University of Turin, Turin, Italy., Discepolo V; Department of Translational Medical Sciences, Section of Pediatrics, University of Naples Federico II, Napoli, Italy., Lo Vecchio A; Department of Translational Medical Sciences, Section of Pediatrics, University of Naples Federico II, Napoli, Italy., Guarino A; Department of Translational Medical Sciences, Section of Pediatrics, University of Naples Federico II, Napoli, Italy., Eisenstein EM; Department of Pediatrics, Hadassah-Hebrew University Medical Center, Mount Scopus, Jerusalem, Israel., Imberti L; CREA Laboratory (AIL Center for Hemato-Oncologic Research), Diagnostic Department, ASST Spedali Civili di Brescia, Brescia, Italy., Sottini A; CREA Laboratory (AIL Center for Hemato-Oncologic Research), Diagnostic Department, ASST Spedali Civili di Brescia, Brescia, Italy., Biondi A; Pediatric Department and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN, University of Milano Bicocca, Fondazione MBBM, Ospedale San Gerardo, Monza, Italy., Mató S; Randall Children's Hospital at Legacy Emanuel, Portland, OR, USA., Gerstbacher D; Division of Pediatric Rheumatology, Stanford Children's Hospital, Stanford, CA, USA., Truong M; Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Stack MA; Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Magliocco M; Molecular Development of the Immune System Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Bosticardo M; Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Kawai T; Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Danielson JJ; Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Hulett T; CDI Laboratories, Antygen Division, Baltimore, MD, USA., Askenazi M; CDI Laboratories, Antygen Division, Baltimore, MD, USA., Hu S; CDI Laboratories, Antygen Division, Baltimore, MD, USA., Cohen JI; Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Su HC; Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Kuhns DB; Applied/Developmental Research Directorate, Frederick National Laboratory for Cancer Research, Frederick, MD, USA., Lionakis MS; Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Snyder TM; Adaptive Biotechnologies, Seattle, WA, USA., Holland SM; Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Goldbach-Mansky R; Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Tsang JS; Multiscale Systems Biology Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.; NIH Center for Human Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Notarangelo LD; Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA. luigi.notarangelo2@nih.gov.
Corporate Authors: NIAID Immune Response to COVID Group, Chile MIS-C Group, Pavia Pediatric COVID-19 Group
Source: Nature medicine [Nat Med] 2022 May; Vol. 28 (5), pp. 1050-1062. Date of Electronic Publication: 2022 Feb 17.
Publication Type: Journal Article; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
Journal Info: Publisher: Nature Publishing Company Country of Publication: United States NLM ID: 9502015 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-170X (Electronic) Linking ISSN: 10788956 NLM ISO Abbreviation: Nat Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Immunopathological signatures in multisystem inflammatory syndrome in children and pediatric COVID-19.
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  Data: <searchLink fieldCode="AU" term="%22Sacco+K%22">Sacco K</searchLink>; Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Castagnoli+R%22">Castagnoli R</searchLink>; Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.; Pediatric Clinic, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy; Department of Clinical, Surgical, Diagnostic and Pediatric Sciences, University of Pavia, Pavia, Italy.<br /><searchLink fieldCode="AU" term="%22Vakkilainen+S%22">Vakkilainen S</searchLink>; Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Liu+C%22">Liu C</searchLink>; Multiscale Systems Biology Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.; Graduate Program in Biological Sciences, University of Maryland, College Park, MD, USA.<br /><searchLink fieldCode="AU" term="%22Delmonte+OM%22">Delmonte OM</searchLink>; Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Oguz+C%22">Oguz C</searchLink>; NIAID Collaborative Bioinformatics Resource (NCBR), National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.; Advanced Biomedical Computational Science, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc, Frederick, MD, USA.<br /><searchLink fieldCode="AU" term="%22Kaplan+IM%22">Kaplan IM</searchLink>; Adaptive Biotechnologies, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Alehashemi+S%22">Alehashemi S</searchLink>; Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Burbelo+PD%22">Burbelo PD</searchLink>; National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Bhuyan+F%22">Bhuyan F</searchLink>; Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22de+Jesus+AA%22">de Jesus AA</searchLink>; Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Dobbs+K%22">Dobbs K</searchLink>; Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Rosen+LB%22">Rosen LB</searchLink>; Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Cheng+A%22">Cheng A</searchLink>; Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Shaw+E%22">Shaw E</searchLink>; Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Vakkilainen+MS%22">Vakkilainen MS</searchLink>; Department of Computer Science, Aalto University, Helsinki, Finland.<br /><searchLink fieldCode="AU" term="%22Pala+F%22">Pala F</searchLink>; Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Lack+J%22">Lack J</searchLink>; Multiscale Systems Biology Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.; 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Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.; The American Genome Center, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Chen+J%22">Chen J</searchLink>; Trans-NIH Center for Human Immunology, Autoimmunity, and Inflammation (CHI), National Institutes of Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Sellers+BA%22">Sellers BA</searchLink>; Trans-NIH Center for Human Immunology, Autoimmunity, and Inflammation (CHI), National Institutes of Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Montealegre+Sanchez+GA%22">Montealegre Sanchez GA</searchLink>; Intramural Clinical Management and Operation Branch (ICMOB), Division of Clinical Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Barron+K%22">Barron K</searchLink>; Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Rey-Jurado+E%22">Rey-Jurado E</searchLink>; Facultad de Medicina Clínica Alemana Universidad del Desarrollo, Santiago, Chile.<br /><searchLink fieldCode="AU" term="%22Vial+C%22">Vial C</searchLink>; Facultad de Medicina Clínica Alemana Universidad del Desarrollo, Santiago, Chile.<br /><searchLink fieldCode="AU" term="%22Poli+MC%22">Poli MC</searchLink>; Facultad de Medicina Clínica Alemana Universidad del Desarrollo, Santiago, Chile.; Unidad de Inmunología y Reumatología, Hospital de niños Dr. Roberto del Río, Santiago, Chile.<br /><searchLink fieldCode="AU" term="%22Licari+A%22">Licari A</searchLink>; Pediatric Clinic, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy; Department of Clinical, Surgical, Diagnostic and Pediatric Sciences, University of Pavia, Pavia, Italy.<br /><searchLink fieldCode="AU" term="%22Montagna+D%22">Montagna D</searchLink>; Pediatric Clinic, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy; Department of Clinical, Surgical, Diagnostic and Pediatric Sciences, University of Pavia, Pavia, Italy.; Laboratory of Immunology and Transplantation, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.<br /><searchLink fieldCode="AU" term="%22Marseglia+GL%22">Marseglia GL</searchLink>; Pediatric Clinic, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy; Department of Clinical, Surgical, Diagnostic and Pediatric Sciences, University of Pavia, Pavia, Italy.<br /><searchLink fieldCode="AU" term="%22Licciardi+F%22">Licciardi F</searchLink>; Department of Pediatric and Public Health Sciences, Regina Margherita Children's Hospital, A.O.U. 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Città Della Salute E Della Scienza Di Torino, University of Turin, Turin, Italy.<br /><searchLink fieldCode="AU" term="%22Discepolo+V%22">Discepolo V</searchLink>; Department of Translational Medical Sciences, Section of Pediatrics, University of Naples Federico II, Napoli, Italy.<br /><searchLink fieldCode="AU" term="%22Lo+Vecchio+A%22">Lo Vecchio A</searchLink>; Department of Translational Medical Sciences, Section of Pediatrics, University of Naples Federico II, Napoli, Italy.<br /><searchLink fieldCode="AU" term="%22Guarino+A%22">Guarino A</searchLink>; Department of Translational Medical Sciences, Section of Pediatrics, University of Naples Federico II, Napoli, Italy.<br /><searchLink fieldCode="AU" term="%22Eisenstein+EM%22">Eisenstein EM</searchLink>; Department of Pediatrics, Hadassah-Hebrew University Medical Center, Mount Scopus, Jerusalem, Israel.<br /><searchLink fieldCode="AU" term="%22Imberti+L%22">Imberti L</searchLink>; CREA Laboratory (AIL Center for Hemato-Oncologic Research), Diagnostic Department, ASST Spedali Civili di Brescia, Brescia, Italy.<br /><searchLink fieldCode="AU" term="%22Sottini+A%22">Sottini A</searchLink>; CREA Laboratory (AIL Center for Hemato-Oncologic Research), Diagnostic Department, ASST Spedali Civili di Brescia, Brescia, Italy.<br /><searchLink fieldCode="AU" term="%22Biondi+A%22">Biondi A</searchLink>; Pediatric Department and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN, University of Milano Bicocca, Fondazione MBBM, Ospedale San Gerardo, Monza, Italy.<br /><searchLink fieldCode="AU" term="%22Mató+S%22">Mató S</searchLink>; Randall Children's Hospital at Legacy Emanuel, Portland, OR, USA.<br /><searchLink fieldCode="AU" term="%22Gerstbacher+D%22">Gerstbacher D</searchLink>; Division of Pediatric Rheumatology, Stanford Children's Hospital, Stanford, CA, USA.<br /><searchLink fieldCode="AU" term="%22Truong+M%22">Truong M</searchLink>; Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Stack+MA%22">Stack MA</searchLink>; 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CDI Laboratories, Antygen Division, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Askenazi+M%22">Askenazi M</searchLink>; CDI Laboratories, Antygen Division, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Hu+S%22">Hu S</searchLink>; CDI Laboratories, Antygen Division, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Cohen+JI%22">Cohen JI</searchLink>; Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Su+HC%22">Su HC</searchLink>; Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Kuhns+DB%22">Kuhns DB</searchLink>; Applied/Developmental Research Directorate, Frederick National Laboratory for Cancer Research, Frederick, MD, USA.<br /><searchLink fieldCode="AU" term="%22Lionakis+MS%22">Lionakis MS</searchLink>; 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  Data: <searchLink fieldCode="CA" term="%22NIAID+Immune+Response+to+COVID+Group%22">NIAID Immune Response to COVID Group</searchLink><br /><searchLink fieldCode="CA" term="%22Chile+MIS-C+Group%22">Chile MIS-C Group</searchLink><br /><searchLink fieldCode="CA" term="%22Pavia+Pediatric+COVID-19+Group%22">Pavia Pediatric COVID-19 Group</searchLink>
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  Data: <searchLink fieldCode="JN" term="%229502015%22">Nature medicine</searchLink> [Nat Med] 2022 May; Vol. 28 (5), pp. 1050-1062. <i>Date of Electronic Publication: </i>2022 Feb 17.
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          Dates:
            – D: 01
              M: 05
              Text: 2022 May
              Type: published
              Y: 2022
          Identifiers:
            – Type: issn-electronic
              Value: 1546-170X
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              Value: 28
            – Type: issue
              Value: 5
          Titles:
            – TitleFull: Nature medicine
              Type: main
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