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Synthesis and Evaluation of Novel Tetrahydronaphthyridine CXCR4 Antagonists with Improved Drug-like Profiles.

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Title: Synthesis and Evaluation of Novel Tetrahydronaphthyridine CXCR4 Antagonists with Improved Drug-like Profiles.
Authors: Jecs E; Department of Chemistry, Emory University, 1515 Dickey Drive NE, Atlanta, Georgia 30322, United States., Tahirovic YA; Department of Chemistry, Emory University, 1515 Dickey Drive NE, Atlanta, Georgia 30322, United States., Wilson RJ; Department of Chemistry, Emory University, 1515 Dickey Drive NE, Atlanta, Georgia 30322, United States., Miller EJ; Department of Chemistry, Emory University, 1515 Dickey Drive NE, Atlanta, Georgia 30322, United States., Kim M; Department of Chemistry, Emory University, 1515 Dickey Drive NE, Atlanta, Georgia 30322, United States., Truax V; Department of Chemistry, Emory University, 1515 Dickey Drive NE, Atlanta, Georgia 30322, United States., Nguyen HH; Department of Chemistry, Emory University, 1515 Dickey Drive NE, Atlanta, Georgia 30322, United States., Akins NS; Department of Chemistry, Emory University, 1515 Dickey Drive NE, Atlanta, Georgia 30322, United States., Saindane M; Department of Chemistry, Emory University, 1515 Dickey Drive NE, Atlanta, Georgia 30322, United States., Wang T; Bristol-Myers Squibb Research & Development, Princeton, New Jersey 08543, United States., Sum CS; Bristol-Myers Squibb Research & Development, Princeton, New Jersey 08543, United States., Cvijic ME; Bristol-Myers Squibb Research & Development, Princeton, New Jersey 08543, United States., Schroeder GM; Bristol-Myers Squibb Research & Development, Princeton, New Jersey 08543, United States., Burton SL; Yerkes National Primate Research Center, Emory University, Atlanta, Georgia 30329, United States.; Emory Vaccine Center, Emory University, Atlanta, Georgia 30322, United States., Derdeyn CA; Yerkes National Primate Research Center, Emory University, Atlanta, Georgia 30329, United States.; Emory Vaccine Center, Emory University, Atlanta, Georgia 30322, United States.; Department of Pathology and Laboratory Medicine, School of Medicine, Emory University, Atlanta, Georgia 30322, United States., Xu L; Hangzhou Junrui Biotechnology, Hangzhou, Zhejiang 310000, China., Jiang Y; Hangzhou Junrui Biotechnology, Hangzhou, Zhejiang 310000, China., Wilson LJ; Department of Chemistry, Emory University, 1515 Dickey Drive NE, Atlanta, Georgia 30322, United States., Liotta DC; Department of Chemistry, Emory University, 1515 Dickey Drive NE, Atlanta, Georgia 30322, United States.
Source: Journal of medicinal chemistry [J Med Chem] 2022 Mar 10; Vol. 65 (5), pp. 4058-4084. Date of Electronic Publication: 2022 Feb 18.
Publication Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Synthesis and Evaluation of Novel Tetrahydronaphthyridine CXCR4 Antagonists with Improved Drug-like Profiles.
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  Data: <searchLink fieldCode="AU" term="%22Jecs+E%22">Jecs E</searchLink>; Department of Chemistry, Emory University, 1515 Dickey Drive NE, Atlanta, Georgia 30322, United States.<br /><searchLink fieldCode="AU" term="%22Tahirovic+YA%22">Tahirovic YA</searchLink>; Department of Chemistry, Emory University, 1515 Dickey Drive NE, Atlanta, Georgia 30322, United States.<br /><searchLink fieldCode="AU" term="%22Wilson+RJ%22">Wilson RJ</searchLink>; Department of Chemistry, Emory University, 1515 Dickey Drive NE, Atlanta, Georgia 30322, United States.<br /><searchLink fieldCode="AU" term="%22Miller+EJ%22">Miller EJ</searchLink>; Department of Chemistry, Emory University, 1515 Dickey Drive NE, Atlanta, Georgia 30322, United States.<br /><searchLink fieldCode="AU" term="%22Kim+M%22">Kim M</searchLink>; Department of Chemistry, Emory University, 1515 Dickey Drive NE, Atlanta, Georgia 30322, United States.<br /><searchLink fieldCode="AU" term="%22Truax+V%22">Truax V</searchLink>; Department of Chemistry, Emory University, 1515 Dickey Drive NE, Atlanta, Georgia 30322, United States.<br /><searchLink fieldCode="AU" term="%22Nguyen+HH%22">Nguyen HH</searchLink>; Department of Chemistry, Emory University, 1515 Dickey Drive NE, Atlanta, Georgia 30322, United States.<br /><searchLink fieldCode="AU" term="%22Akins+NS%22">Akins NS</searchLink>; Department of Chemistry, Emory University, 1515 Dickey Drive NE, Atlanta, Georgia 30322, United States.<br /><searchLink fieldCode="AU" term="%22Saindane+M%22">Saindane M</searchLink>; Department of Chemistry, Emory University, 1515 Dickey Drive NE, Atlanta, Georgia 30322, United States.<br /><searchLink fieldCode="AU" term="%22Wang+T%22">Wang T</searchLink>; Bristol-Myers Squibb Research & Development, Princeton, New Jersey 08543, United States.<br /><searchLink fieldCode="AU" term="%22Sum+CS%22">Sum CS</searchLink>; Bristol-Myers Squibb Research & Development, Princeton, New Jersey 08543, United States.<br /><searchLink fieldCode="AU" term="%22Cvijic+ME%22">Cvijic ME</searchLink>; Bristol-Myers Squibb Research & Development, Princeton, New Jersey 08543, United States.<br /><searchLink fieldCode="AU" term="%22Schroeder+GM%22">Schroeder GM</searchLink>; Bristol-Myers Squibb Research & Development, Princeton, New Jersey 08543, United States.<br /><searchLink fieldCode="AU" term="%22Burton+SL%22">Burton SL</searchLink>; Yerkes National Primate Research Center, Emory University, Atlanta, Georgia 30329, United States.; Emory Vaccine Center, Emory University, Atlanta, Georgia 30322, United States.<br /><searchLink fieldCode="AU" term="%22Derdeyn+CA%22">Derdeyn CA</searchLink>; Yerkes National Primate Research Center, Emory University, Atlanta, Georgia 30329, United States.; Emory Vaccine Center, Emory University, Atlanta, Georgia 30322, United States.; Department of Pathology and Laboratory Medicine, School of Medicine, Emory University, Atlanta, Georgia 30322, United States.<br /><searchLink fieldCode="AU" term="%22Xu+L%22">Xu L</searchLink>; Hangzhou Junrui Biotechnology, Hangzhou, Zhejiang 310000, China.<br /><searchLink fieldCode="AU" term="%22Jiang+Y%22">Jiang Y</searchLink>; Hangzhou Junrui Biotechnology, Hangzhou, Zhejiang 310000, China.<br /><searchLink fieldCode="AU" term="%22Wilson+LJ%22">Wilson LJ</searchLink>; Department of Chemistry, Emory University, 1515 Dickey Drive NE, Atlanta, Georgia 30322, United States.<br /><searchLink fieldCode="AU" term="%22Liotta+DC%22">Liotta DC</searchLink>; Department of Chemistry, Emory University, 1515 Dickey Drive NE, Atlanta, Georgia 30322, United States.
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  Data: <searchLink fieldCode="JN" term="%229716531%22">Journal of medicinal chemistry</searchLink> [J Med Chem] 2022 Mar 10; Vol. 65 (5), pp. 4058-4084. <i>Date of Electronic Publication: </i>2022 Feb 18.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Chemical+Society%22">American Chemical Society </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>9716531 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1520-4804 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200222623%22">00222623 </searchLink><i>NLM ISO Abbreviation: </i>J Med Chem <i>Subsets: </i>MEDLINE
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        Value: 10.1021/acs.jmedchem.1c01564
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