Synthesis and Evaluation of Novel Tetrahydronaphthyridine CXCR4 Antagonists with Improved Drug-like Profiles.
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| Title: | Synthesis and Evaluation of Novel Tetrahydronaphthyridine CXCR4 Antagonists with Improved Drug-like Profiles. |
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| Authors: | Jecs E; Department of Chemistry, Emory University, 1515 Dickey Drive NE, Atlanta, Georgia 30322, United States., Tahirovic YA; Department of Chemistry, Emory University, 1515 Dickey Drive NE, Atlanta, Georgia 30322, United States., Wilson RJ; Department of Chemistry, Emory University, 1515 Dickey Drive NE, Atlanta, Georgia 30322, United States., Miller EJ; Department of Chemistry, Emory University, 1515 Dickey Drive NE, Atlanta, Georgia 30322, United States., Kim M; Department of Chemistry, Emory University, 1515 Dickey Drive NE, Atlanta, Georgia 30322, United States., Truax V; Department of Chemistry, Emory University, 1515 Dickey Drive NE, Atlanta, Georgia 30322, United States., Nguyen HH; Department of Chemistry, Emory University, 1515 Dickey Drive NE, Atlanta, Georgia 30322, United States., Akins NS; Department of Chemistry, Emory University, 1515 Dickey Drive NE, Atlanta, Georgia 30322, United States., Saindane M; Department of Chemistry, Emory University, 1515 Dickey Drive NE, Atlanta, Georgia 30322, United States., Wang T; Bristol-Myers Squibb Research & Development, Princeton, New Jersey 08543, United States., Sum CS; Bristol-Myers Squibb Research & Development, Princeton, New Jersey 08543, United States., Cvijic ME; Bristol-Myers Squibb Research & Development, Princeton, New Jersey 08543, United States., Schroeder GM; Bristol-Myers Squibb Research & Development, Princeton, New Jersey 08543, United States., Burton SL; Yerkes National Primate Research Center, Emory University, Atlanta, Georgia 30329, United States.; Emory Vaccine Center, Emory University, Atlanta, Georgia 30322, United States., Derdeyn CA; Yerkes National Primate Research Center, Emory University, Atlanta, Georgia 30329, United States.; Emory Vaccine Center, Emory University, Atlanta, Georgia 30322, United States.; Department of Pathology and Laboratory Medicine, School of Medicine, Emory University, Atlanta, Georgia 30322, United States., Xu L; Hangzhou Junrui Biotechnology, Hangzhou, Zhejiang 310000, China., Jiang Y; Hangzhou Junrui Biotechnology, Hangzhou, Zhejiang 310000, China., Wilson LJ; Department of Chemistry, Emory University, 1515 Dickey Drive NE, Atlanta, Georgia 30322, United States., Liotta DC; Department of Chemistry, Emory University, 1515 Dickey Drive NE, Atlanta, Georgia 30322, United States. |
| Source: | Journal of medicinal chemistry [J Med Chem] 2022 Mar 10; Vol. 65 (5), pp. 4058-4084. Date of Electronic Publication: 2022 Feb 18. |
| Publication Type: | Journal Article; Research Support, U.S. Gov't, Non-P.H.S. |
| Journal Info: | Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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