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An Fc-inert PD-L1×4-1BB bispecific antibody mediates potent anti-tumor immunity in mice by combining checkpoint inhibition and conditional 4-1BB co-stimulation.

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Title: An Fc-inert PD-L1×4-1BB bispecific antibody mediates potent anti-tumor immunity in mice by combining checkpoint inhibition and conditional 4-1BB co-stimulation.
Authors: Muik A; BioNTech SE, Mainz, Germany., Altintas I; Genmab, Utrecht, The Netherlands., Gieseke F; BioNTech SE, Mainz, Germany., Schoedel KB; BioNTech SE, Mainz, Germany., Burm SM; Genmab, Utrecht, The Netherlands., Toker A; BioNTech SE, Mainz, Germany., Salcedo TW; Genmab, Princeton, NJ, USA., Verzijl D; BioNTech SE, Mainz, Germany.; Genmab, Utrecht, The Netherlands.; Genmab, Princeton, NJ, USA.; TRON - Translational Oncology at the University Medical Center of the Johannes Gutenberg University gGmbH, Mainz, Germany., Eisel D; BioNTech SE, Mainz, Germany., Grunwitz C; BioNTech SE, Mainz, Germany., Kranz LM; BioNTech SE, Mainz, Germany., Vormehr M; BioNTech SE, Mainz, Germany., Satijn DPE; BioNTech SE, Mainz, Germany.; Genmab, Utrecht, The Netherlands.; Genmab, Princeton, NJ, USA.; TRON - Translational Oncology at the University Medical Center of the Johannes Gutenberg University gGmbH, Mainz, Germany., Diken M; BioNTech SE, Mainz, Germany., Kreiter S; BioNTech SE, Mainz, Germany., Sasser K; Genmab, Princeton, NJ, USA., Ahmadi T; BioNTech SE, Mainz, Germany.; Genmab, Utrecht, The Netherlands.; Genmab, Princeton, NJ, USA.; TRON - Translational Oncology at the University Medical Center of the Johannes Gutenberg University gGmbH, Mainz, Germany., Türeci Ö; BioNTech SE, Mainz, Germany., Breij ECW; Genmab, Utrecht, The Netherlands., Jure-Kunkel M; Genmab, Princeton, NJ, USA., Sahin U; BioNTech SE, Mainz, Germany.; TRON - Translational Oncology at the University Medical Center of the Johannes Gutenberg University gGmbH, Mainz, Germany.
Source: Oncoimmunology [Oncoimmunology] 2022 Feb 16; Vol. 11 (1), pp. 2030135. Date of Electronic Publication: 2022 Feb 16 (Print Publication: 2022).
Publication Type: Journal Article
Journal Info: Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101570526 Publication Model: eCollection Cited Medium: Internet ISSN: 2162-402X (Electronic) Linking ISSN: 21624011 NLM ISO Abbreviation: Oncoimmunology Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: An Fc-inert PD-L1×4-1BB bispecific antibody mediates potent anti-tumor immunity in mice by combining checkpoint inhibition and conditional 4-1BB co-stimulation.
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  Data: <searchLink fieldCode="AU" term="%22Muik+A%22">Muik A</searchLink>; BioNTech SE, Mainz, Germany.<br /><searchLink fieldCode="AU" term="%22Altintas+I%22">Altintas I</searchLink>; Genmab, Utrecht, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Gieseke+F%22">Gieseke F</searchLink>; BioNTech SE, Mainz, Germany.<br /><searchLink fieldCode="AU" term="%22Schoedel+KB%22">Schoedel KB</searchLink>; BioNTech SE, Mainz, Germany.<br /><searchLink fieldCode="AU" term="%22Burm+SM%22">Burm SM</searchLink>; Genmab, Utrecht, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Toker+A%22">Toker A</searchLink>; BioNTech SE, Mainz, Germany.<br /><searchLink fieldCode="AU" term="%22Salcedo+TW%22">Salcedo TW</searchLink>; Genmab, Princeton, NJ, USA.<br /><searchLink fieldCode="AU" term="%22Verzijl+D%22">Verzijl D</searchLink>; BioNTech SE, Mainz, Germany.; Genmab, Utrecht, The Netherlands.; Genmab, Princeton, NJ, USA.; TRON - Translational Oncology at the University Medical Center of the Johannes Gutenberg University gGmbH, Mainz, Germany.<br /><searchLink fieldCode="AU" term="%22Eisel+D%22">Eisel D</searchLink>; BioNTech SE, Mainz, Germany.<br /><searchLink fieldCode="AU" term="%22Grunwitz+C%22">Grunwitz C</searchLink>; BioNTech SE, Mainz, Germany.<br /><searchLink fieldCode="AU" term="%22Kranz+LM%22">Kranz LM</searchLink>; BioNTech SE, Mainz, Germany.<br /><searchLink fieldCode="AU" term="%22Vormehr+M%22">Vormehr M</searchLink>; BioNTech SE, Mainz, Germany.<br /><searchLink fieldCode="AU" term="%22Satijn+DPE%22">Satijn DPE</searchLink>; BioNTech SE, Mainz, Germany.; Genmab, Utrecht, The Netherlands.; Genmab, Princeton, NJ, USA.; TRON - Translational Oncology at the University Medical Center of the Johannes Gutenberg University gGmbH, Mainz, Germany.<br /><searchLink fieldCode="AU" term="%22Diken+M%22">Diken M</searchLink>; BioNTech SE, Mainz, Germany.<br /><searchLink fieldCode="AU" term="%22Kreiter+S%22">Kreiter S</searchLink>; BioNTech SE, Mainz, Germany.<br /><searchLink fieldCode="AU" term="%22Sasser+K%22">Sasser K</searchLink>; Genmab, Princeton, NJ, USA.<br /><searchLink fieldCode="AU" term="%22Ahmadi+T%22">Ahmadi T</searchLink>; BioNTech SE, Mainz, Germany.; Genmab, Utrecht, The Netherlands.; Genmab, Princeton, NJ, USA.; TRON - Translational Oncology at the University Medical Center of the Johannes Gutenberg University gGmbH, Mainz, Germany.<br /><searchLink fieldCode="AU" term="%22Türeci+Ö%22">Türeci Ö</searchLink>; BioNTech SE, Mainz, Germany.<br /><searchLink fieldCode="AU" term="%22Breij+ECW%22">Breij ECW</searchLink>; Genmab, Utrecht, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Jure-Kunkel+M%22">Jure-Kunkel M</searchLink>; Genmab, Princeton, NJ, USA.<br /><searchLink fieldCode="AU" term="%22Sahin+U%22">Sahin U</searchLink>; BioNTech SE, Mainz, Germany.; TRON - Translational Oncology at the University Medical Center of the Johannes Gutenberg University gGmbH, Mainz, Germany.
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  Data: <searchLink fieldCode="JN" term="%22101570526%22">Oncoimmunology</searchLink> [Oncoimmunology] 2022 Feb 16; Vol. 11 (1), pp. 2030135. <i>Date of Electronic Publication: </i>2022 Feb 16 (<i>Print Publication: </i>2022).
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Taylor+%26+Francis%22">Taylor & Francis </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101570526 <i>Publication Model: </i>eCollection <i>Cited Medium: </i>Internet <i>ISSN: </i>2162-402X (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2221624011%22">21624011 </searchLink><i>NLM ISO Abbreviation: </i>Oncoimmunology <i>Subsets: </i>MEDLINE
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