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JAK1 signaling in dendritic cells promotes peripheral tolerance in autoimmunity through PD-L1-mediated regulatory T cell induction.

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Title: JAK1 signaling in dendritic cells promotes peripheral tolerance in autoimmunity through PD-L1-mediated regulatory T cell induction.
Authors: Vogel A; Institute for Vascular Biology, Centre for Physiology and Pharmacology, Medical University Vienna, Vienna, Austria; Christian Doppler Laboratory for Arginine Metabolism in Rheumatoid Arthritis and Multiple Sclerosis, Vienna, Austria., Martin K; St. Anna Children's Cancer Research Institute, Vienna, Austria., Soukup K; St. Anna Children's Cancer Research Institute, Vienna, Austria., Halfmann A; St. Anna Children's Cancer Research Institute, Vienna, Austria., Kerndl M; Institute for Vascular Biology, Centre for Physiology and Pharmacology, Medical University Vienna, Vienna, Austria; Christian Doppler Laboratory for Arginine Metabolism in Rheumatoid Arthritis and Multiple Sclerosis, Vienna, Austria., Brunner JS; Institute for Vascular Biology, Centre for Physiology and Pharmacology, Medical University Vienna, Vienna, Austria; Christian Doppler Laboratory for Arginine Metabolism in Rheumatoid Arthritis and Multiple Sclerosis, Vienna, Austria., Hofmann M; Institute for Vascular Biology, Centre for Physiology and Pharmacology, Medical University Vienna, Vienna, Austria; Christian Doppler Laboratory for Arginine Metabolism in Rheumatoid Arthritis and Multiple Sclerosis, Vienna, Austria., Oberbichler L; Institute for Vascular Biology, Centre for Physiology and Pharmacology, Medical University Vienna, Vienna, Austria; Christian Doppler Laboratory for Arginine Metabolism in Rheumatoid Arthritis and Multiple Sclerosis, Vienna, Austria., Korosec A; Institute for Vascular Biology, Centre for Physiology and Pharmacology, Medical University Vienna, Vienna, Austria; Christian Doppler Laboratory for Arginine Metabolism in Rheumatoid Arthritis and Multiple Sclerosis, Vienna, Austria., Kuttke M; Institute for Vascular Biology, Centre for Physiology and Pharmacology, Medical University Vienna, Vienna, Austria; Christian Doppler Laboratory for Arginine Metabolism in Rheumatoid Arthritis and Multiple Sclerosis, Vienna, Austria., Datler H; Institute for Vascular Biology, Centre for Physiology and Pharmacology, Medical University Vienna, Vienna, Austria; Christian Doppler Laboratory for Arginine Metabolism in Rheumatoid Arthritis and Multiple Sclerosis, Vienna, Austria., Kieler M; Institute for Vascular Biology, Centre for Physiology and Pharmacology, Medical University Vienna, Vienna, Austria; Christian Doppler Laboratory for Arginine Metabolism in Rheumatoid Arthritis and Multiple Sclerosis, Vienna, Austria., Musiejovsky L; Institute for Vascular Biology, Centre for Physiology and Pharmacology, Medical University Vienna, Vienna, Austria; Christian Doppler Laboratory for Arginine Metabolism in Rheumatoid Arthritis and Multiple Sclerosis, Vienna, Austria., Dohnal A; St. Anna Children's Cancer Research Institute, Vienna, Austria. Electronic address: alexander.dohnal@apeiron-biologics.com., Sharif O; Institute for Vascular Biology, Centre for Physiology and Pharmacology, Medical University Vienna, Vienna, Austria; Christian Doppler Laboratory for Arginine Metabolism in Rheumatoid Arthritis and Multiple Sclerosis, Vienna, Austria. Electronic address: omar.sharif@meduniwien.ac.at., Schabbauer G; Institute for Vascular Biology, Centre for Physiology and Pharmacology, Medical University Vienna, Vienna, Austria; Christian Doppler Laboratory for Arginine Metabolism in Rheumatoid Arthritis and Multiple Sclerosis, Vienna, Austria. Electronic address: gernot.schabbauer@meduniwien.ac.at.
Source: Cell reports [Cell Rep] 2022 Feb 22; Vol. 38 (8), pp. 110420.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101573691 Publication Model: Print Cited Medium: Internet ISSN: 2211-1247 (Electronic) NLM ISO Abbreviation: Cell Rep Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: JAK1 signaling in dendritic cells promotes peripheral tolerance in autoimmunity through PD-L1-mediated regulatory T cell induction.
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  Data: <searchLink fieldCode="AU" term="%22Vogel+A%22">Vogel A</searchLink>; Institute for Vascular Biology, Centre for Physiology and Pharmacology, Medical University Vienna, Vienna, Austria; Christian Doppler Laboratory for Arginine Metabolism in Rheumatoid Arthritis and Multiple Sclerosis, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Martin+K%22">Martin K</searchLink>; St. Anna Children's Cancer Research Institute, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Soukup+K%22">Soukup K</searchLink>; St. Anna Children's Cancer Research Institute, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Halfmann+A%22">Halfmann A</searchLink>; St. Anna Children's Cancer Research Institute, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Kerndl+M%22">Kerndl M</searchLink>; Institute for Vascular Biology, Centre for Physiology and Pharmacology, Medical University Vienna, Vienna, Austria; Christian Doppler Laboratory for Arginine Metabolism in Rheumatoid Arthritis and Multiple Sclerosis, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Brunner+JS%22">Brunner JS</searchLink>; Institute for Vascular Biology, Centre for Physiology and Pharmacology, Medical University Vienna, Vienna, Austria; Christian Doppler Laboratory for Arginine Metabolism in Rheumatoid Arthritis and Multiple Sclerosis, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Hofmann+M%22">Hofmann M</searchLink>; Institute for Vascular Biology, Centre for Physiology and Pharmacology, Medical University Vienna, Vienna, Austria; Christian Doppler Laboratory for Arginine Metabolism in Rheumatoid Arthritis and Multiple Sclerosis, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Oberbichler+L%22">Oberbichler L</searchLink>; Institute for Vascular Biology, Centre for Physiology and Pharmacology, Medical University Vienna, Vienna, Austria; Christian Doppler Laboratory for Arginine Metabolism in Rheumatoid Arthritis and Multiple Sclerosis, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Korosec+A%22">Korosec A</searchLink>; Institute for Vascular Biology, Centre for Physiology and Pharmacology, Medical University Vienna, Vienna, Austria; Christian Doppler Laboratory for Arginine Metabolism in Rheumatoid Arthritis and Multiple Sclerosis, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Kuttke+M%22">Kuttke M</searchLink>; Institute for Vascular Biology, Centre for Physiology and Pharmacology, Medical University Vienna, Vienna, Austria; Christian Doppler Laboratory for Arginine Metabolism in Rheumatoid Arthritis and Multiple Sclerosis, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Datler+H%22">Datler H</searchLink>; Institute for Vascular Biology, Centre for Physiology and Pharmacology, Medical University Vienna, Vienna, Austria; Christian Doppler Laboratory for Arginine Metabolism in Rheumatoid Arthritis and Multiple Sclerosis, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Kieler+M%22">Kieler M</searchLink>; Institute for Vascular Biology, Centre for Physiology and Pharmacology, Medical University Vienna, Vienna, Austria; Christian Doppler Laboratory for Arginine Metabolism in Rheumatoid Arthritis and Multiple Sclerosis, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Musiejovsky+L%22">Musiejovsky L</searchLink>; Institute for Vascular Biology, Centre for Physiology and Pharmacology, Medical University Vienna, Vienna, Austria; Christian Doppler Laboratory for Arginine Metabolism in Rheumatoid Arthritis and Multiple Sclerosis, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Dohnal+A%22">Dohnal A</searchLink>; St. Anna Children's Cancer Research Institute, Vienna, Austria. Electronic address: alexander.dohnal@apeiron-biologics.com.<br /><searchLink fieldCode="AU" term="%22Sharif+O%22">Sharif O</searchLink>; Institute for Vascular Biology, Centre for Physiology and Pharmacology, Medical University Vienna, Vienna, Austria; Christian Doppler Laboratory for Arginine Metabolism in Rheumatoid Arthritis and Multiple Sclerosis, Vienna, Austria. Electronic address: omar.sharif@meduniwien.ac.at.<br /><searchLink fieldCode="AU" term="%22Schabbauer+G%22">Schabbauer G</searchLink>; Institute for Vascular Biology, Centre for Physiology and Pharmacology, Medical University Vienna, Vienna, Austria; Christian Doppler Laboratory for Arginine Metabolism in Rheumatoid Arthritis and Multiple Sclerosis, Vienna, Austria. Electronic address: gernot.schabbauer@meduniwien.ac.at.
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