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Short-chain fatty acid acetate triggers antiviral response mediated by RIG-I in cells from infants with respiratory syncytial virus bronchiolitis.

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Title: Short-chain fatty acid acetate triggers antiviral response mediated by RIG-I in cells from infants with respiratory syncytial virus bronchiolitis.
Authors: Antunes KH; Laboratory of Clinical and Experimental Immunology, Health and Life Science School - Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, Rio Grande do Sul 90610-000, Brazil., Stein RT; Department of Pediatrics, School of Medicine, PUCRS, São Lucas Hospital PUCRS, Porto Alegre, Rio Grande do Sul 90610-000, Brazil. Electronic address: rstein@pucrs.br., Franceschina C; Laboratory of Clinical and Experimental Immunology, Health and Life Science School - Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, Rio Grande do Sul 90610-000, Brazil., da Silva EF; Laboratory of Clinical and Experimental Immunology, Health and Life Science School - Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, Rio Grande do Sul 90610-000, Brazil., de Freitas DN; Laboratory of Clinical and Experimental Immunology, Health and Life Science School - Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, Rio Grande do Sul 90610-000, Brazil., Silveira J; Laboratory of Clinical and Experimental Immunology, Health and Life Science School - Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, Rio Grande do Sul 90610-000, Brazil., Mocellin M; Laboratory of Clinical and Experimental Immunology, Health and Life Science School - Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, Rio Grande do Sul 90610-000, Brazil., Leitão L; Laboratory of Clinical and Experimental Immunology, Health and Life Science School - Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, Rio Grande do Sul 90610-000, Brazil., Fachi JL; Laboratory of Immunoinflammation, Department of Genetics, Evolution, Microbiology and Immunology - Institute of Biology, University of Campinas, Campinas, São Paulo 13083-862, Brazil., Pral LP; Laboratory of Immunoinflammation, Department of Genetics, Evolution, Microbiology and Immunology - Institute of Biology, University of Campinas, Campinas, São Paulo 13083-862, Brazil., Gonzalez A; Laboratory of Clinical and Experimental Immunology, Health and Life Science School - Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, Rio Grande do Sul 90610-000, Brazil., Oliveira S; Laboratory of Immunoinflammation, Department of Genetics, Evolution, Microbiology and Immunology - Institute of Biology, University of Campinas, Campinas, São Paulo 13083-862, Brazil., Duarte L; Laboratory of Clinical and Experimental Immunology, Health and Life Science School - Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, Rio Grande do Sul 90610-000, Brazil., Cassão G; Laboratory of Clinical and Experimental Immunology, Health and Life Science School - Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, Rio Grande do Sul 90610-000, Brazil., Gonçalves JIB; Laboratory of Clinical and Experimental Immunology, Health and Life Science School - Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, Rio Grande do Sul 90610-000, Brazil., Reis TM; Laboratory of Clinical and Experimental Immunology, Health and Life Science School - Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, Rio Grande do Sul 90610-000, Brazil., Abbadi BL; Centro de Pesquisas em Biologia Molecular e Funcional (CPBMF), Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, Brazil., Dornelles M; Centro de Pesquisas em Biologia Molecular e Funcional (CPBMF), Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, Brazil., Sperotto NDM; Centro de Pesquisas em Biologia Molecular e Funcional (CPBMF), Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, Brazil., Rigo M; Laboratory of Clinical and Experimental Immunology, Health and Life Science School - Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, Rio Grande do Sul 90610-000, Brazil., Rodrigues H; Laboratory of Nutritional Genomics, School of Applied Sciences, University of Campinas, Limeira, São Paulo, Brazil., Jones M; Department of Pediatrics, School of Medicine, PUCRS, São Lucas Hospital PUCRS, Porto Alegre, Rio Grande do Sul 90610-000, Brazil., Epifanio M; Department of Pediatrics, School of Medicine, PUCRS, São Lucas Hospital PUCRS, Porto Alegre, Rio Grande do Sul 90610-000, Brazil., Guima S; Department of Biochemistry, Chemistry Institute, University of São Paulo, São Paulo, São Paulo, Brazil., Setubal JC; Department of Biochemistry, Chemistry Institute, University of São Paulo, São Paulo, São Paulo, Brazil., Jorge TR; Laboratory of Imunobiology, Department of Microbiology, Immunology and Parasitology, Universidade Federal de Santa Catarina, Florianópolis, Santa Catarina, Brazil., Mansur DS; Laboratory of Imunobiology, Department of Microbiology, Immunology and Parasitology, Universidade Federal de Santa Catarina, Florianópolis, Santa Catarina, Brazil., Mayer FQ; Molecular Biology Laboratory, Veterinary Research Institute Desidério Finamor, Agricultural Diagnosis and Research Department, Secretariat of Agriculture, Livestock and Irrigation, Eldorado do Sul, Rio Grande do Sul, Brazil., Varela APM; Molecular Biology Laboratory, Veterinary Research Institute Desidério Finamor, Agricultural Diagnosis and Research Department, Secretariat of Agriculture, Livestock and Irrigation, Eldorado do Sul, Rio Grande do Sul, Brazil., Bizarro CV; Centro de Pesquisas em Biologia Molecular e Funcional (CPBMF), Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, Brazil., Machado P; Centro de Pesquisas em Biologia Molecular e Funcional (CPBMF), Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, Brazil., Basso LA; Centro de Pesquisas em Biologia Molecular e Funcional (CPBMF), Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, Brazil., Polack FP; Fundación Infant, Buenos Aires, Argentina., Custovic A; National Heart and Lung Institute, Imperial College London, UK., Vinolo MAR; Department of Pediatrics, School of Medicine, PUCRS, São Lucas Hospital PUCRS, Porto Alegre, Rio Grande do Sul 90610-000, Brazil. Electronic address: mvinolo@g.unicamp.br., de Souza APD; Laboratory of Clinical and Experimental Immunology, Health and Life Science School - Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, Rio Grande do Sul 90610-000, Brazil. Electronic address: ana.duarte@pucrs.br.
Source: EBioMedicine [EBioMedicine] 2022 Mar; Vol. 77, pp. 103891. Date of Electronic Publication: 2022 Feb 24.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier B.V Country of Publication: Netherlands NLM ID: 101647039 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2352-3964 (Electronic) Linking ISSN: 23523964 NLM ISO Abbreviation: EBioMedicine Subsets: MEDLINE
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  Data: Short-chain fatty acid acetate triggers antiviral response mediated by RIG-I in cells from infants with respiratory syncytial virus bronchiolitis.
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  Data: <searchLink fieldCode="AU" term="%22Antunes+KH%22">Antunes KH</searchLink>; Laboratory of Clinical and Experimental Immunology, Health and Life Science School - Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, Rio Grande do Sul 90610-000, Brazil.<br /><searchLink fieldCode="AU" term="%22Stein+RT%22">Stein RT</searchLink>; Department of Pediatrics, School of Medicine, PUCRS, São Lucas Hospital PUCRS, Porto Alegre, Rio Grande do Sul 90610-000, Brazil. 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Laboratory of Clinical and Experimental Immunology, Health and Life Science School - Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, Rio Grande do Sul 90610-000, Brazil.<br /><searchLink fieldCode="AU" term="%22Leitão+L%22">Leitão L</searchLink>; Laboratory of Clinical and Experimental Immunology, Health and Life Science School - Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, Rio Grande do Sul 90610-000, Brazil.<br /><searchLink fieldCode="AU" term="%22Fachi+JL%22">Fachi JL</searchLink>; Laboratory of Immunoinflammation, Department of Genetics, Evolution, Microbiology and Immunology - Institute of Biology, University of Campinas, Campinas, São Paulo 13083-862, Brazil.<br /><searchLink fieldCode="AU" term="%22Pral+LP%22">Pral LP</searchLink>; Laboratory of Immunoinflammation, Department of Genetics, Evolution, Microbiology and Immunology - Institute of Biology, University of Campinas, Campinas, São Paulo 13083-862, Brazil.<br /><searchLink fieldCode="AU" term="%22Gonzalez+A%22">Gonzalez A</searchLink>; 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Laboratory of Clinical and Experimental Immunology, Health and Life Science School - Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, Rio Grande do Sul 90610-000, Brazil.<br /><searchLink fieldCode="AU" term="%22Reis+TM%22">Reis TM</searchLink>; Laboratory of Clinical and Experimental Immunology, Health and Life Science School - Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, Rio Grande do Sul 90610-000, Brazil.<br /><searchLink fieldCode="AU" term="%22Abbadi+BL%22">Abbadi BL</searchLink>; Centro de Pesquisas em Biologia Molecular e Funcional (CPBMF), Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, Brazil.<br /><searchLink fieldCode="AU" term="%22Dornelles+M%22">Dornelles M</searchLink>; Centro de Pesquisas em Biologia Molecular e Funcional (CPBMF), Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, Brazil.<br /><searchLink fieldCode="AU" term="%22Sperotto+NDM%22">Sperotto NDM</searchLink>; Centro de Pesquisas em Biologia Molecular e Funcional (CPBMF), Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, Brazil.<br /><searchLink fieldCode="AU" term="%22Rigo+M%22">Rigo M</searchLink>; 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Department of Biochemistry, Chemistry Institute, University of São Paulo, São Paulo, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Jorge+TR%22">Jorge TR</searchLink>; Laboratory of Imunobiology, Department of Microbiology, Immunology and Parasitology, Universidade Federal de Santa Catarina, Florianópolis, Santa Catarina, Brazil.<br /><searchLink fieldCode="AU" term="%22Mansur+DS%22">Mansur DS</searchLink>; Laboratory of Imunobiology, Department of Microbiology, Immunology and Parasitology, Universidade Federal de Santa Catarina, Florianópolis, Santa Catarina, Brazil.<br /><searchLink fieldCode="AU" term="%22Mayer+FQ%22">Mayer FQ</searchLink>; Molecular Biology Laboratory, Veterinary Research Institute Desidério Finamor, Agricultural Diagnosis and Research Department, Secretariat of Agriculture, Livestock and Irrigation, Eldorado do Sul, Rio Grande do Sul, Brazil.<br /><searchLink fieldCode="AU" term="%22Varela+APM%22">Varela APM</searchLink>; Molecular Biology Laboratory, Veterinary Research Institute Desidério Finamor, Agricultural Diagnosis and Research Department, Secretariat of Agriculture, Livestock and Irrigation, Eldorado do Sul, Rio Grande do Sul, Brazil.<br /><searchLink fieldCode="AU" term="%22Bizarro+CV%22">Bizarro CV</searchLink>; Centro de Pesquisas em Biologia Molecular e Funcional (CPBMF), Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, Brazil.<br /><searchLink fieldCode="AU" term="%22Machado+P%22">Machado P</searchLink>; Centro de Pesquisas em Biologia Molecular e Funcional (CPBMF), Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, Brazil.<br /><searchLink fieldCode="AU" term="%22Basso+LA%22">Basso LA</searchLink>; Centro de Pesquisas em Biologia Molecular e Funcional (CPBMF), Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, Brazil.<br /><searchLink fieldCode="AU" term="%22Polack+FP%22">Polack FP</searchLink>; Fundación Infant, Buenos Aires, Argentina.<br /><searchLink fieldCode="AU" term="%22Custovic+A%22">Custovic A</searchLink>; National Heart and Lung Institute, Imperial College London, UK.<br /><searchLink fieldCode="AU" term="%22Vinolo+MAR%22">Vinolo MAR</searchLink>; Department of Pediatrics, School of Medicine, PUCRS, São Lucas Hospital PUCRS, Porto Alegre, Rio Grande do Sul 90610-000, Brazil. 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