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Using polygenic scores and clinical data for bipolar disorder patient stratification and lithium response prediction: machine learning approach.

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Title: Using polygenic scores and clinical data for bipolar disorder patient stratification and lithium response prediction: machine learning approach.
Authors: Cearns M; Discipline of Psychiatry, School of Medicine, University of Adelaide, Australia., Amare AT; South Australian Academic Health Science and Translation Centre, South Australian Health and Medical Research Institute (SAHMRI), Australia and Program for Quantitative Genomics, Harvard School of Public Health, USA., Schubert KO; Discipline of Psychiatry, School of Medicine, University of Adelaide, Australia and Northern Adelaide Local Health Network, Mental Health Services, Australia., Thalamuthu A; Centre for Healthy Brain Ageing (CHeBA), School of Psychiatry, University of New South Wales, Australia., Frank J; Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Germany., Streit F; Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Germany., Adli M; Department of Psychiatry and Psychotherapy, Charité - Universitätsmedizin Berlin, Campus Charité Mitte, Germany., Akula N; Intramural Research Program, National Institute of Mental Health, National Institutes of Health, US Department of Health & Human Services, USA., Akiyama K; Department of Biological Psychiatry and Neuroscience, Dokkyo Medical University School of Medicine, Japan., Ardau R; Unit of Clinical Pharmacology, Hospital University Agency of Cagliari, Italy., Arias B; Unitat de Zoologia i Antropologia Biològica (Dpt. Biologia Evolutiva, Ecologia i Ciències Ambientals), Facultat de Biologia and Institut de Biomedicina (IBUB), University of Barcelona, CIBERSAM, Spain., Aubry JM; Department of Psychiatry, Mood Disorders Unit, HUG - Geneva University Hospitals, Switzerland., Backlund L; Department of Molecular Medicine and Surgery, Karolinska Institute, Sweden and Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden., Bhattacharjee AK; Department of Psychiatry, University of California San Diego, USA., Bellivier F; INSERM UMR-S 1144, Université Paris Diderot, Département de Psychiatrie et de Médecine Addictologique, AP-HP, Groupe Hospitalier Saint-Louis-Lariboisière-F.Widal, France., Benabarre A; Bipolar Disorder Program, Institute of Neuroscience, Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, Spain., Bengesser S; Department of Psychiatry and Psychotherapeutic Medicine, Research Unit for Bipolar Affective Disorder, Medical University of Graz, Austria., Biernacka JM; Department of Health Sciences Research, Mayo Clinic, USA and Department of Psychiatry and Psychology, Mayo Clinic, USA., Birner A; Department of Psychiatry and Psychotherapeutic Medicine, Research Unit for Bipolar Affective Disorder, Medical University of Graz, Austria., Brichant-Petitjean C; INSERM UMR-S 1144, Université Paris Diderot, Département de Psychiatrie et de Médecine Addictologique, AP-HP, Groupe Hospitalier Saint-Louis-Lariboisière-F.Widal, France., Cervantes P; The Neuromodulation Unit, McGill University Health Centre, Canada., Chen HC; Department of Psychiatry & Center of Sleep Disorders, National Taiwan University Hospital, Taiwan., Chillotti C; Unit of Clinical Pharmacology, Hospital University Agency of Cagliari, Italy., Cichon S; Institute of Human Genetics, University of Bonn and Department of Genomics, Life & Brain Center, Germany; and Human Genomics Research Group, Department of Biomedicine, University Hospital Basel, Switzerland., Cruceanu C; Douglas Mental Health University Institute, McGill University, Canada., Czerski PM; Psychiatric Genetic Unit, Poznan University of Medical Sciences, Poland., Dalkner N; Department of Psychiatry and Psychotherapeutic Medicine, Research Unit for Bipolar Affective Disorder, Medical University of Graz, Austria., Dayer A; Department of Psychiatry, Mood Disorders Unit, HUG - Geneva University Hospitals, Switzerland., Degenhardt F; Institute of Human Genetics, University of Bonn and Department of Genomics, Life & Brain Center, Germany., Zompo MD; Department of Biomedical Sciences, University of Cagliari, Italy., DePaulo JR; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, USA., Étain B; INSERM UMR-S 1144, Université Paris Diderot, Département de Psychiatrie et de Médecine Addictologique, AP-HP, Groupe Hospitalier Saint-Louis-Lariboisière-F.Widal, France., Falkai P; Department of Psychiatry and Psychotherapy, Ludwig-Maximilian-University Munich, Germany., Forstner AJ; Institute of Human Genetics, University of Bonn and Department of Genomics, Life & Brain Center, Germany; Human Genomics Research Group, Department of Biomedicine, University Hospital Basel, Switzerland and Department of Psychiatry (UPK), University of Basel, Switzerland., Frisen L; Department of Molecular Medicine and Surgery, Karolinska Institute, Sweden and Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden., Frye MA; Department of Psychiatry and Psychology, Mayo Clinic, USA., Fullerton JM; Neuroscience Research Australia, Australia and School of Medical Sciences, University of New South Wales, Australia., Gard S; Service de Psychiatrie, Hôpital Charles Perrens, France., Garnham JS; Department of Psychiatry, Dalhousie University, Canada., Goes FS; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, USA., Grigoroiu-Serbanescu M; Biometric Psychiatric Genetics Research Unit, Alexandru Obregia Clinical Psychiatric Hospital, Romania., Grof P; Mood Disorders Center of Ottawa, Canada., Hashimoto R; Molecular Research Center for Children's Mental Development, United Graduate School of Child Development, Osaka University, Japan and Department of Psychiatry, Osaka University Graduate School of Medicine, Japan., Hauser J; Psychiatric Genetic Unit, Poznan University of Medical Sciences, Poland., Heilbronner U; Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Germany and Department of Psychiatry and Psychotherapy, University Medical Center (UMG), Georg-August University Göttingen, Germany., Herms S; Institute of Human Genetics, University of Bonn and Department of Genomics, Life & Brain Center, Germany and Human Genomics Research Group, Department of Biomedicine, University Hospital Basel, Switzerland., Hoffmann P; Institute of Human Genetics, University of Bonn and Department of Genomics, Life & Brain Center, Germany and Human Genomics Research Group, Department of Biomedicine, University Hospital Basel, Switzerland., Hofmann A; Institute of Human Genetics, University of Bonn and Department of Genomics, Life & Brain Center, Germany., Hou L; Intramural Research Program, National Institute of Mental Health, National Institutes of Health, US Department of Health & Human Services, USA., Hsu YH; Program for Quantitative Genomics, Harvard School of Public Health, USA and HSL Institute for Aging Research, Harvard Medical School, USA., Jamain S; Univ Paris Est Créteil, INSERM, IMRB, Translational Neuropsychiatry, Fondation FondaMental, France., Jiménez E; Bipolar Disorder Program, Institute of Neuroscience, Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, Spain., Kahn JP; Service de Psychiatrie et Psychologie Clinique, Centre Psychothérapique de Nancy - Université de Lorraine, France., Kassem L; Intramural Research Program, National Institute of Mental Health, National Institutes of Health, US Department of Health & Human Services, USA., Kuo PH; Department of Public Health & Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taiwan., Kato T; Department of Psychiatry & Behavioral Science, Juntendo University, Graduate School of Medicine, Japan., Kelsoe J; Department of Psychiatry, University of California San Diego, USA., Kittel-Schneider S; Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Germany., Kliwicki S; Department of Adult Psychiatry, Poznan University of Medical Sciences, Poland., König B; Department of Psychiatry and Psychotherapeutic Medicine, Landesklinikum Neunkirchen, Austria., Kusumi I; Department of Psychiatry, Hokkaido University Graduate School of Medicine, Japan., Laje G; Intramural Research Program, National Institute of Mental Health, National Institutes of Health, US Department of Health & Human Services, USA., Landén M; Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the Gothenburg University, Sweden and Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Sweden., Lavebratt C; Department of Molecular Medicine and Surgery, Karolinska Institute, Sweden and Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden., Leboyer M; Univ Paris Est Créteil, INSERM, IMRB, Translational Neuropsychiatry, AP-HP, Mondor University Hospital, DMU Impact, Fondation FondaMental, France., Leckband SG; Office of Mental Health, VA San Diego Healthcare System, USA., Maj M; Department of Psychiatry, University of Campania 'Luigi Vanvitelli', Italy; ,for a full list of Major Depressive Disorder Working Group of the PGC Investigators, see the Supplementary Material., Manchia M; Section of Psychiatry, Department of Medical Sciences and Public Health, University of Cagliari, Italy and Department of Pharmacology, Dalhousie University, Canada., Martinsson L; Department of Clinical Neurosciences, Karolinska Institutet, Sweden., McCarthy MJ; Department of Psychiatry, University of California San Diego, USA and Department of Psychiatry, VA San Diego Healthcare System, USA., McElroy S; Department of Psychiatry, Lindner Center of Hope / University of Cincinnati, USA., Colom F; Mental Health Research Group, IMIM-Hospital del Mar, Spain and Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Spain., Mitjans M; Mental Health Research Group, IMIM-Hospital del Mar, Spain and Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Spain., Mondimore FM; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, USA., Monteleone P; Department of Medicine, Surgery and Dentistry 'Scuola Medica Salernitana', University of Salerno, Italy., Nievergelt CM; Department of Psychiatry, University of California San Diego, USA., Nöthen MM; Institute of Human Genetics, University of Bonn and Department of Genomics, Life & Brain Center, Germany., Novák T; National Institute of Mental Health, Czech Republic., O'Donovan C; Department of Psychiatry, Dalhousie University, Canada., Ozaki N; Department of Psychiatry & Department of Child and Adolescent Psychiatry, Nagoya University Graduate School of Medicine, Japan., Millischer V; Department of Molecular Medicine and Surgery, Karolinska Institute, Sweden and Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden and Department of Psychiatry and Psychotherapy, Medical University of Vienna, Austria., Papiol S; Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Germany and Department of Psychiatry and Psychotherapy, Ludwig-Maximilian-University Munich, Germany., Pfennig A; Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Medical Faculty, Technische Universität Dresden, Germany., Pisanu C; Department of Biomedical Sciences, University of Cagliari, Italy., Potash JB; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, USA., Reif A; Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Germany., Reininghaus E; Department of Psychiatry and Psychotherapeutic Medicine, Research Unit for Bipolar Affective Disorder, Medical University of Graz, Austria., Rouleau GA; Montreal Neurological Institute and Hospital, McGill University, Canada., Rybakowski JK; Department of Adult Psychiatry, Poznan University of Medical Sciences, Poland., Schalling M; Department of Molecular Medicine and Surgery, Karolinska Institute, Sweden and Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden., Schofield PR; Neuroscience Research Australia, Australia and School of Medical Sciences, University of New South Wales, Australia., Schweizer BW; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, USA., Severino G; Department of Biomedical Sciences, University of Cagliari, Italy., Shekhtman T; Department of Psychiatry, University of California San Diego, USA., Shilling PD; Department of Psychiatry, University of California San Diego, USA., Shimoda K; Department of Psychiatry, Dokkyo Medical University School of Medicine, Japan., Simhandl C; Bipolar Center Wiener Neustadt, Sigmund Freud University, Medical Faculty, Austria., Slaney CM; Department of Psychiatry, Dalhousie University, Canada., Squassina A; Department of Biomedical Sciences, University of Cagliari, Italy., Stamm T; Department of Psychiatry and Psychotherapy, Charité - Universitätsmedizin Berlin, Campus Charité Mitte, Germany., Stopkova P; National Institute of Mental Health, Czech Republic., Tekola-Ayele F; Epidemiology Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, USA., Tortorella A; Department of Psychiatry, University of Perugia, Italy., Turecki G; Douglas Mental Health University Institute, McGill University, Canada., Veeh J; Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Germany., Vieta E; Bipolar Disorder Program, Institute of Neuroscience, Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, Spain., Witt SH; Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Germany., Roberts G; School of Psychiatry, University of New South Wales, Australia., Zandi PP; Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, USA., Alda M; Department of Psychiatry, Dalhousie University, Canada., Bauer M; Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Medical Faculty, Technische Universität Dresden, Germany., McMahon FJ; Intramural Research Program, National Institute of Mental Health, National Institutes of Health, US Department of Health & Human Services, USA., Mitchell PB; School of Psychiatry, University of New South Wales, Australia., Schulze TG; Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Germany; Intramural Research Program, National Institute of Mental Health, National Institutes of Health, US Department of Health & Human Services, USA, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, USA; Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Germany and Department of Psychiatry and Psychotherapy, University Medical Center (UMG), Georg-August University Göttingen, Germany., Rietschel M; Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Germany., Clark SR; Discipline of Psychiatry, School of Medicine, University of Adelaide, Australia., Baune BT; Department of Psychiatry and Psychotherapy, University of Münster, Germany; Department of Psychiatry, Melbourne Medical School, University of Melbourne, Australia and The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Australia.
Corporate Authors: Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium
Source: The British journal of psychiatry : the journal of mental science [Br J Psychiatry] 2022 Apr; Vol. 220 (4), pp. 219-228. Date of Electronic Publication: 2022 Feb 28.
Publication Type: Journal Article
Journal Info: Publisher: Cambridge University Press Country of Publication: England NLM ID: 0342367 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1472-1465 (Electronic) Linking ISSN: 00071250 NLM ISO Abbreviation: Br J Psychiatry Subsets: MEDLINE; PubMed not MEDLINE
Database: MEDLINE Ultimate
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Items – Name: Title
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  Data: Using polygenic scores and clinical data for bipolar disorder patient stratification and lithium response prediction: machine learning approach.
– Name: Author
  Label: Authors
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  Data: <searchLink fieldCode="AU" term="%22Cearns+M%22">Cearns M</searchLink>; Discipline of Psychiatry, School of Medicine, University of Adelaide, Australia.<br /><searchLink fieldCode="AU" term="%22Amare+AT%22">Amare AT</searchLink>; South Australian Academic Health Science and Translation Centre, South Australian Health and Medical Research Institute (SAHMRI), Australia and Program for Quantitative Genomics, Harvard School of Public Health, USA.<br /><searchLink fieldCode="AU" term="%22Schubert+KO%22">Schubert KO</searchLink>; Discipline of Psychiatry, School of Medicine, University of Adelaide, Australia and Northern Adelaide Local Health Network, Mental Health Services, Australia.<br /><searchLink fieldCode="AU" term="%22Thalamuthu+A%22">Thalamuthu A</searchLink>; Centre for Healthy Brain Ageing (CHeBA), School of Psychiatry, University of New South Wales, Australia.<br /><searchLink fieldCode="AU" term="%22Frank+J%22">Frank J</searchLink>; Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Streit+F%22">Streit F</searchLink>; Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Adli+M%22">Adli M</searchLink>; Department of Psychiatry and Psychotherapy, Charité - Universitätsmedizin Berlin, Campus Charité Mitte, Germany.<br /><searchLink fieldCode="AU" term="%22Akula+N%22">Akula N</searchLink>; Intramural Research Program, National Institute of Mental Health, National Institutes of Health, US Department of Health & Human Services, USA.<br /><searchLink fieldCode="AU" term="%22Akiyama+K%22">Akiyama K</searchLink>; Department of Biological Psychiatry and Neuroscience, Dokkyo Medical University School of Medicine, Japan.<br /><searchLink fieldCode="AU" term="%22Ardau+R%22">Ardau R</searchLink>; Unit of Clinical Pharmacology, Hospital University Agency of Cagliari, Italy.<br /><searchLink fieldCode="AU" term="%22Arias+B%22">Arias B</searchLink>; Unitat de Zoologia i Antropologia Biològica (Dpt. Biologia Evolutiva, Ecologia i Ciències Ambientals), Facultat de Biologia and Institut de Biomedicina (IBUB), University of Barcelona, CIBERSAM, Spain.<br /><searchLink fieldCode="AU" term="%22Aubry+JM%22">Aubry JM</searchLink>; Department of Psychiatry, Mood Disorders Unit, HUG - Geneva University Hospitals, Switzerland.<br /><searchLink fieldCode="AU" term="%22Backlund+L%22">Backlund L</searchLink>; Department of Molecular Medicine and Surgery, Karolinska Institute, Sweden and Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Bhattacharjee+AK%22">Bhattacharjee AK</searchLink>; Department of Psychiatry, University of California San Diego, USA.<br /><searchLink fieldCode="AU" term="%22Bellivier+F%22">Bellivier F</searchLink>; INSERM UMR-S 1144, Université Paris Diderot, Département de Psychiatrie et de Médecine Addictologique, AP-HP, Groupe Hospitalier Saint-Louis-Lariboisière-F.Widal, France.<br /><searchLink fieldCode="AU" term="%22Benabarre+A%22">Benabarre A</searchLink>; Bipolar Disorder Program, Institute of Neuroscience, Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, Spain.<br /><searchLink fieldCode="AU" term="%22Bengesser+S%22">Bengesser S</searchLink>; Department of Psychiatry and Psychotherapeutic Medicine, Research Unit for Bipolar Affective Disorder, Medical University of Graz, Austria.<br /><searchLink fieldCode="AU" term="%22Biernacka+JM%22">Biernacka JM</searchLink>; Department of Health Sciences Research, Mayo Clinic, USA and Department of Psychiatry and Psychology, Mayo Clinic, USA.<br /><searchLink fieldCode="AU" term="%22Birner+A%22">Birner A</searchLink>; Department of Psychiatry and Psychotherapeutic Medicine, Research Unit for Bipolar Affective Disorder, Medical University of Graz, Austria.<br /><searchLink fieldCode="AU" term="%22Brichant-Petitjean+C%22">Brichant-Petitjean C</searchLink>; INSERM UMR-S 1144, Université Paris Diderot, Département de Psychiatrie et de Médecine Addictologique, AP-HP, Groupe Hospitalier Saint-Louis-Lariboisière-F.Widal, France.<br /><searchLink fieldCode="AU" term="%22Cervantes+P%22">Cervantes P</searchLink>; The Neuromodulation Unit, McGill University Health Centre, Canada.<br /><searchLink fieldCode="AU" term="%22Chen+HC%22">Chen HC</searchLink>; Department of Psychiatry & Center of Sleep Disorders, National Taiwan University Hospital, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chillotti+C%22">Chillotti C</searchLink>; Unit of Clinical Pharmacology, Hospital University Agency of Cagliari, Italy.<br /><searchLink fieldCode="AU" term="%22Cichon+S%22">Cichon S</searchLink>; Institute of Human Genetics, University of Bonn and Department of Genomics, Life & Brain Center, Germany; and Human Genomics Research Group, Department of Biomedicine, University Hospital Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Cruceanu+C%22">Cruceanu C</searchLink>; Douglas Mental Health University Institute, McGill University, Canada.<br /><searchLink fieldCode="AU" term="%22Czerski+PM%22">Czerski PM</searchLink>; Psychiatric Genetic Unit, Poznan University of Medical Sciences, Poland.<br /><searchLink fieldCode="AU" term="%22Dalkner+N%22">Dalkner N</searchLink>; Department of Psychiatry and Psychotherapeutic Medicine, Research Unit for Bipolar Affective Disorder, Medical University of Graz, Austria.<br /><searchLink fieldCode="AU" term="%22Dayer+A%22">Dayer A</searchLink>; Department of Psychiatry, Mood Disorders Unit, HUG - Geneva University Hospitals, Switzerland.<br /><searchLink fieldCode="AU" term="%22Degenhardt+F%22">Degenhardt F</searchLink>; Institute of Human Genetics, University of Bonn and Department of Genomics, Life & Brain Center, Germany.<br /><searchLink fieldCode="AU" term="%22Zompo+MD%22">Zompo MD</searchLink>; Department of Biomedical Sciences, University of Cagliari, Italy.<br /><searchLink fieldCode="AU" term="%22DePaulo+JR%22">DePaulo JR</searchLink>; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, USA.<br /><searchLink fieldCode="AU" term="%22Étain+B%22">Étain B</searchLink>; INSERM UMR-S 1144, Université Paris Diderot, Département de Psychiatrie et de Médecine Addictologique, AP-HP, Groupe Hospitalier Saint-Louis-Lariboisière-F.Widal, France.<br /><searchLink fieldCode="AU" term="%22Falkai+P%22">Falkai P</searchLink>; Department of Psychiatry and Psychotherapy, Ludwig-Maximilian-University Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Forstner+AJ%22">Forstner AJ</searchLink>; Institute of Human Genetics, University of Bonn and Department of Genomics, Life & Brain Center, Germany; Human Genomics Research Group, Department of Biomedicine, University Hospital Basel, Switzerland and Department of Psychiatry (UPK), University of Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Frisen+L%22">Frisen L</searchLink>; Department of Molecular Medicine and Surgery, Karolinska Institute, Sweden and Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Frye+MA%22">Frye MA</searchLink>; Department of Psychiatry and Psychology, Mayo Clinic, USA.<br /><searchLink fieldCode="AU" term="%22Fullerton+JM%22">Fullerton JM</searchLink>; Neuroscience Research Australia, Australia and School of Medical Sciences, University of New South Wales, Australia.<br /><searchLink fieldCode="AU" term="%22Gard+S%22">Gard S</searchLink>; Service de Psychiatrie, Hôpital Charles Perrens, France.<br /><searchLink fieldCode="AU" term="%22Garnham+JS%22">Garnham JS</searchLink>; Department of Psychiatry, Dalhousie University, Canada.<br /><searchLink fieldCode="AU" term="%22Goes+FS%22">Goes FS</searchLink>; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, USA.<br /><searchLink fieldCode="AU" term="%22Grigoroiu-Serbanescu+M%22">Grigoroiu-Serbanescu M</searchLink>; Biometric Psychiatric Genetics Research Unit, Alexandru Obregia Clinical Psychiatric Hospital, Romania.<br /><searchLink fieldCode="AU" term="%22Grof+P%22">Grof P</searchLink>; Mood Disorders Center of Ottawa, Canada.<br /><searchLink fieldCode="AU" term="%22Hashimoto+R%22">Hashimoto R</searchLink>; Molecular Research Center for Children's Mental Development, United Graduate School of Child Development, Osaka University, Japan and Department of Psychiatry, Osaka University Graduate School of Medicine, Japan.<br /><searchLink fieldCode="AU" term="%22Hauser+J%22">Hauser J</searchLink>; Psychiatric Genetic Unit, Poznan University of Medical Sciences, Poland.<br /><searchLink fieldCode="AU" term="%22Heilbronner+U%22">Heilbronner U</searchLink>; Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Germany and Department of Psychiatry and Psychotherapy, University Medical Center (UMG), Georg-August University Göttingen, Germany.<br /><searchLink fieldCode="AU" term="%22Herms+S%22">Herms S</searchLink>; Institute of Human Genetics, University of Bonn and Department of Genomics, Life & Brain Center, Germany and Human Genomics Research Group, Department of Biomedicine, University Hospital Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Hoffmann+P%22">Hoffmann P</searchLink>; Institute of Human Genetics, University of Bonn and Department of Genomics, Life & Brain Center, Germany and Human Genomics Research Group, Department of Biomedicine, University Hospital Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Hofmann+A%22">Hofmann A</searchLink>; Institute of Human Genetics, University of Bonn and Department of Genomics, Life & Brain Center, Germany.<br /><searchLink fieldCode="AU" term="%22Hou+L%22">Hou L</searchLink>; Intramural Research Program, National Institute of Mental Health, National Institutes of Health, US Department of Health & Human Services, USA.<br /><searchLink fieldCode="AU" term="%22Hsu+YH%22">Hsu YH</searchLink>; Program for Quantitative Genomics, Harvard School of Public Health, USA and HSL Institute for Aging Research, Harvard Medical School, USA.<br /><searchLink fieldCode="AU" term="%22Jamain+S%22">Jamain S</searchLink>; Univ Paris Est Créteil, INSERM, IMRB, Translational Neuropsychiatry, Fondation FondaMental, France.<br /><searchLink fieldCode="AU" term="%22Jiménez+E%22">Jiménez E</searchLink>; Bipolar Disorder Program, Institute of Neuroscience, Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, Spain.<br /><searchLink fieldCode="AU" term="%22Kahn+JP%22">Kahn JP</searchLink>; Service de Psychiatrie et Psychologie Clinique, Centre Psychothérapique de Nancy - Université de Lorraine, France.<br /><searchLink fieldCode="AU" term="%22Kassem+L%22">Kassem L</searchLink>; Intramural Research Program, National Institute of Mental Health, National Institutes of Health, US Department of Health & Human Services, USA.<br /><searchLink fieldCode="AU" term="%22Kuo+PH%22">Kuo PH</searchLink>; Department of Public Health & Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taiwan.<br /><searchLink fieldCode="AU" term="%22Kato+T%22">Kato T</searchLink>; Department of Psychiatry & Behavioral Science, Juntendo University, Graduate School of Medicine, Japan.<br /><searchLink fieldCode="AU" term="%22Kelsoe+J%22">Kelsoe J</searchLink>; Department of Psychiatry, University of California San Diego, USA.<br /><searchLink fieldCode="AU" term="%22Kittel-Schneider+S%22">Kittel-Schneider S</searchLink>; Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Germany.<br /><searchLink fieldCode="AU" term="%22Kliwicki+S%22">Kliwicki S</searchLink>; Department of Adult Psychiatry, Poznan University of Medical Sciences, Poland.<br /><searchLink fieldCode="AU" term="%22König+B%22">König B</searchLink>; Department of Psychiatry and Psychotherapeutic Medicine, Landesklinikum Neunkirchen, Austria.<br /><searchLink fieldCode="AU" term="%22Kusumi+I%22">Kusumi I</searchLink>; Department of Psychiatry, Hokkaido University Graduate School of Medicine, Japan.<br /><searchLink fieldCode="AU" term="%22Laje+G%22">Laje G</searchLink>; Intramural Research Program, National Institute of Mental Health, National Institutes of Health, US Department of Health & Human Services, USA.<br /><searchLink fieldCode="AU" term="%22Landén+M%22">Landén M</searchLink>; Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the Gothenburg University, Sweden and Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Sweden.<br /><searchLink fieldCode="AU" term="%22Lavebratt+C%22">Lavebratt C</searchLink>; Department of Molecular Medicine and Surgery, Karolinska Institute, Sweden and Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Leboyer+M%22">Leboyer M</searchLink>; Univ Paris Est Créteil, INSERM, IMRB, Translational Neuropsychiatry, AP-HP, Mondor University Hospital, DMU Impact, Fondation FondaMental, France.<br /><searchLink fieldCode="AU" term="%22Leckband+SG%22">Leckband SG</searchLink>; Office of Mental Health, VA San Diego Healthcare System, USA.<br /><searchLink fieldCode="AU" term="%22Maj+M%22">Maj M</searchLink>; Department of Psychiatry, University of Campania 'Luigi Vanvitelli', Italy; ,for a full list of Major Depressive Disorder Working Group of the PGC Investigators, see the Supplementary Material.<br /><searchLink fieldCode="AU" term="%22Manchia+M%22">Manchia M</searchLink>; Section of Psychiatry, Department of Medical Sciences and Public Health, University of Cagliari, Italy and Department of Pharmacology, Dalhousie University, Canada.<br /><searchLink fieldCode="AU" term="%22Martinsson+L%22">Martinsson L</searchLink>; Department of Clinical Neurosciences, Karolinska Institutet, Sweden.<br /><searchLink fieldCode="AU" term="%22McCarthy+MJ%22">McCarthy MJ</searchLink>; Department of Psychiatry, University of California San Diego, USA and Department of Psychiatry, VA San Diego Healthcare System, USA.<br /><searchLink fieldCode="AU" term="%22McElroy+S%22">McElroy S</searchLink>; Department of Psychiatry, Lindner Center of Hope / University of Cincinnati, USA.<br /><searchLink fieldCode="AU" term="%22Colom+F%22">Colom F</searchLink>; Mental Health Research Group, IMIM-Hospital del Mar, Spain and Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Spain.<br /><searchLink fieldCode="AU" term="%22Mitjans+M%22">Mitjans M</searchLink>; Mental Health Research Group, IMIM-Hospital del Mar, Spain and Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Spain.<br /><searchLink fieldCode="AU" term="%22Mondimore+FM%22">Mondimore FM</searchLink>; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, USA.<br /><searchLink fieldCode="AU" term="%22Monteleone+P%22">Monteleone P</searchLink>; Department of Medicine, Surgery and Dentistry 'Scuola Medica Salernitana', University of Salerno, Italy.<br /><searchLink fieldCode="AU" term="%22Nievergelt+CM%22">Nievergelt CM</searchLink>; Department of Psychiatry, University of California San Diego, USA.<br /><searchLink fieldCode="AU" term="%22Nöthen+MM%22">Nöthen MM</searchLink>; Institute of Human Genetics, University of Bonn and Department of Genomics, Life & Brain Center, Germany.<br /><searchLink fieldCode="AU" term="%22Novák+T%22">Novák T</searchLink>; National Institute of Mental Health, Czech Republic.<br /><searchLink fieldCode="AU" term="%22O'Donovan+C%22">O'Donovan C</searchLink>; Department of Psychiatry, Dalhousie University, Canada.<br /><searchLink fieldCode="AU" term="%22Ozaki+N%22">Ozaki N</searchLink>; Department of Psychiatry & Department of Child and Adolescent Psychiatry, Nagoya University Graduate School of Medicine, Japan.<br /><searchLink fieldCode="AU" term="%22Millischer+V%22">Millischer V</searchLink>; Department of Molecular Medicine and Surgery, Karolinska Institute, Sweden and Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden and Department of Psychiatry and Psychotherapy, Medical University of Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Papiol+S%22">Papiol S</searchLink>; Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Germany and Department of Psychiatry and Psychotherapy, Ludwig-Maximilian-University Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Pfennig+A%22">Pfennig A</searchLink>; Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Medical Faculty, Technische Universität Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Pisanu+C%22">Pisanu C</searchLink>; Department of Biomedical Sciences, University of Cagliari, Italy.<br /><searchLink fieldCode="AU" term="%22Potash+JB%22">Potash JB</searchLink>; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, USA.<br /><searchLink fieldCode="AU" term="%22Reif+A%22">Reif A</searchLink>; Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Germany.<br /><searchLink fieldCode="AU" term="%22Reininghaus+E%22">Reininghaus E</searchLink>; Department of Psychiatry and Psychotherapeutic Medicine, Research Unit for Bipolar Affective Disorder, Medical University of Graz, Austria.<br /><searchLink fieldCode="AU" term="%22Rouleau+GA%22">Rouleau GA</searchLink>; Montreal Neurological Institute and Hospital, McGill University, Canada.<br /><searchLink fieldCode="AU" term="%22Rybakowski+JK%22">Rybakowski JK</searchLink>; Department of Adult Psychiatry, Poznan University of Medical Sciences, Poland.<br /><searchLink fieldCode="AU" term="%22Schalling+M%22">Schalling M</searchLink>; Department of Molecular Medicine and Surgery, Karolinska Institute, Sweden and Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Schofield+PR%22">Schofield PR</searchLink>; Neuroscience Research Australia, Australia and School of Medical Sciences, University of New South Wales, Australia.<br /><searchLink fieldCode="AU" term="%22Schweizer+BW%22">Schweizer BW</searchLink>; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, USA.<br /><searchLink fieldCode="AU" term="%22Severino+G%22">Severino G</searchLink>; Department of Biomedical Sciences, University of Cagliari, Italy.<br /><searchLink fieldCode="AU" term="%22Shekhtman+T%22">Shekhtman T</searchLink>; Department of Psychiatry, University of California San Diego, USA.<br /><searchLink fieldCode="AU" term="%22Shilling+PD%22">Shilling PD</searchLink>; Department of Psychiatry, University of California San Diego, USA.<br /><searchLink fieldCode="AU" term="%22Shimoda+K%22">Shimoda K</searchLink>; Department of Psychiatry, Dokkyo Medical University School of Medicine, Japan.<br /><searchLink fieldCode="AU" term="%22Simhandl+C%22">Simhandl C</searchLink>; Bipolar Center Wiener Neustadt, Sigmund Freud University, Medical Faculty, Austria.<br /><searchLink fieldCode="AU" term="%22Slaney+CM%22">Slaney CM</searchLink>; Department of Psychiatry, Dalhousie University, Canada.<br /><searchLink fieldCode="AU" term="%22Squassina+A%22">Squassina A</searchLink>; Department of Biomedical Sciences, University of Cagliari, Italy.<br /><searchLink fieldCode="AU" term="%22Stamm+T%22">Stamm T</searchLink>; Department of Psychiatry and Psychotherapy, Charité - Universitätsmedizin Berlin, Campus Charité Mitte, Germany.<br /><searchLink fieldCode="AU" term="%22Stopkova+P%22">Stopkova P</searchLink>; National Institute of Mental Health, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Tekola-Ayele+F%22">Tekola-Ayele F</searchLink>; Epidemiology Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, USA.<br /><searchLink fieldCode="AU" term="%22Tortorella+A%22">Tortorella A</searchLink>; Department of Psychiatry, University of Perugia, Italy.<br /><searchLink fieldCode="AU" term="%22Turecki+G%22">Turecki G</searchLink>; Douglas Mental Health University Institute, McGill University, Canada.<br /><searchLink fieldCode="AU" term="%22Veeh+J%22">Veeh J</searchLink>; Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Germany.<br /><searchLink fieldCode="AU" term="%22Vieta+E%22">Vieta E</searchLink>; Bipolar Disorder Program, Institute of Neuroscience, Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, Spain.<br /><searchLink fieldCode="AU" term="%22Witt+SH%22">Witt SH</searchLink>; Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Roberts+G%22">Roberts G</searchLink>; School of Psychiatry, University of New South Wales, Australia.<br /><searchLink fieldCode="AU" term="%22Zandi+PP%22">Zandi PP</searchLink>; Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, USA.<br /><searchLink fieldCode="AU" term="%22Alda+M%22">Alda M</searchLink>; Department of Psychiatry, Dalhousie University, Canada.<br /><searchLink fieldCode="AU" term="%22Bauer+M%22">Bauer M</searchLink>; Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Medical Faculty, Technische Universität Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22McMahon+FJ%22">McMahon FJ</searchLink>; Intramural Research Program, National Institute of Mental Health, National Institutes of Health, US Department of Health & Human Services, USA.<br /><searchLink fieldCode="AU" term="%22Mitchell+PB%22">Mitchell PB</searchLink>; School of Psychiatry, University of New South Wales, Australia.<br /><searchLink fieldCode="AU" term="%22Schulze+TG%22">Schulze TG</searchLink>; Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Germany; Intramural Research Program, National Institute of Mental Health, National Institutes of Health, US Department of Health & Human Services, USA, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, USA; Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Germany and Department of Psychiatry and Psychotherapy, University Medical Center (UMG), Georg-August University Göttingen, Germany.<br /><searchLink fieldCode="AU" term="%22Rietschel+M%22">Rietschel M</searchLink>; Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Clark+SR%22">Clark SR</searchLink>; Discipline of Psychiatry, School of Medicine, University of Adelaide, Australia.<br /><searchLink fieldCode="AU" term="%22Baune+BT%22">Baune BT</searchLink>; Department of Psychiatry and Psychotherapy, University of Münster, Germany; Department of Psychiatry, Melbourne Medical School, University of Melbourne, Australia and The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Australia.
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  Data: <searchLink fieldCode="CA" term="%22Major+Depressive+Disorder+Working+Group+of+the+Psychiatric+Genomics+Consortium%22">Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium</searchLink>
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  Data: <searchLink fieldCode="JN" term="%220342367%22">The British journal of psychiatry : the journal of mental science</searchLink> [Br J Psychiatry] 2022 Apr; Vol. 220 (4), pp. 219-228. <i>Date of Electronic Publication: </i>2022 Feb 28.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Cambridge+University+Press%22">Cambridge University Press </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>0342367 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1472-1465 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200071250%22">00071250 </searchLink><i>NLM ISO Abbreviation: </i>Br J Psychiatry <i>Subsets: </i>MEDLINE; PubMed not MEDLINE
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        Value: 10.1192/bjp.2022.28
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        Text: English
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      – TitleFull: Using polygenic scores and clinical data for bipolar disorder patient stratification and lithium response prediction: machine learning approach.
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            NameFull: Schweizer BW
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            NameFull: Severino G
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            NameFull: Shekhtman T
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            NameFull: Shilling PD
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            NameFull: Shimoda K
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            NameFull: Simhandl C
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          Name:
            NameFull: Slaney CM
      – PersonEntity:
          Name:
            NameFull: Squassina A
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            NameFull: Stamm T
      – PersonEntity:
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      – PersonEntity:
          Name:
            NameFull: Tekola-Ayele F
      – PersonEntity:
          Name:
            NameFull: Tortorella A
      – PersonEntity:
          Name:
            NameFull: Turecki G
      – PersonEntity:
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            NameFull: Veeh J
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            NameFull: Vieta E
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            NameFull: Zandi PP
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            NameFull: Alda M
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          Name:
            NameFull: Bauer M
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            NameFull: McMahon FJ
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            NameFull: Mitchell PB
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          Name:
            NameFull: Schulze TG
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          Name:
            NameFull: Rietschel M
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            NameFull: Clark SR
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            NameFull: Baune BT
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 04
              Text: 2022 Apr
              Type: published
              Y: 2022
          Identifiers:
            – Type: issn-electronic
              Value: 1472-1465
          Numbering:
            – Type: volume
              Value: 220
            – Type: issue
              Value: 4
          Titles:
            – TitleFull: The British journal of psychiatry : the journal of mental science
              Type: main
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