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Nivolumab plus ipilimumab with or without live bacterial supplementation in metastatic renal cell carcinoma: a randomized phase 1 trial.

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Title: Nivolumab plus ipilimumab with or without live bacterial supplementation in metastatic renal cell carcinoma: a randomized phase 1 trial.
Authors: Dizman N; Department of Medical Oncology, City of Hope Comprehensive Cancer Center, Duarte, CA, USA.; Yale University School of Medicine, New Haven, CT, USA., Meza L; Department of Medical Oncology, City of Hope Comprehensive Cancer Center, Duarte, CA, USA., Bergerot P; Cettro Oncologia, Brasilia, Brazil., Alcantara M; Department of Immunology, Beckman Research Institute, City of Hope Comprehensive Cancer Center, Duarte, CA, USA., Dorff T; Department of Medical Oncology, City of Hope Comprehensive Cancer Center, Duarte, CA, USA., Lyou Y; Department of Medical Oncology, City of Hope Comprehensive Cancer Center, Duarte, CA, USA., Frankel P; Division of Biostatistics, City of Hope Comprehensive Cancer Center, Duarte, CA, USA., Cui Y; Division of Biostatistics, City of Hope Comprehensive Cancer Center, Duarte, CA, USA., Mira V; Department of Medical Oncology, City of Hope Comprehensive Cancer Center, Duarte, CA, USA., Llamas M; Department of Medical Oncology, City of Hope Comprehensive Cancer Center, Duarte, CA, USA., Hsu J; Department of Medical Oncology, City of Hope Comprehensive Cancer Center, Duarte, CA, USA., Zengin Z; Department of Medical Oncology, City of Hope Comprehensive Cancer Center, Duarte, CA, USA., Salgia N; Department of Medical Oncology, City of Hope Comprehensive Cancer Center, Duarte, CA, USA., Salgia S; Department of Medical Oncology, City of Hope Comprehensive Cancer Center, Duarte, CA, USA., Malhotra J; Department of Medical Oncology, City of Hope Comprehensive Cancer Center, Duarte, CA, USA., Chawla N; Department of Medical Oncology, City of Hope Comprehensive Cancer Center, Duarte, CA, USA., Chehrazi-Raffle A; Department of Medical Oncology, City of Hope Comprehensive Cancer Center, Duarte, CA, USA., Muddasani R; Department of Medical Oncology, City of Hope Comprehensive Cancer Center, Duarte, CA, USA., Gillece J; The Translational Genomics Research Institute (TGen), Phoenix, AZ, USA., Reining L; The Translational Genomics Research Institute (TGen), Phoenix, AZ, USA., Trent J; The Translational Genomics Research Institute (TGen), Phoenix, AZ, USA., Takahashi M; Miyarisan Pharmaceuticals, Co., Ltd., Tokyo, Japan., Oka K; Miyarisan Pharmaceuticals, Co., Ltd., Tokyo, Japan., Higashi S; Miyarisan Pharmaceuticals, Co., Ltd., Tokyo, Japan., Kortylewski M; Department of Immunology, Beckman Research Institute, City of Hope Comprehensive Cancer Center, Duarte, CA, USA., Highlander SK; The Translational Genomics Research Institute (TGen), Phoenix, AZ, USA. sarah@skhighlander.us., Pal SK; Department of Medical Oncology, City of Hope Comprehensive Cancer Center, Duarte, CA, USA. spal@coh.org.
Source: Nature medicine [Nat Med] 2022 Apr; Vol. 28 (4), pp. 704-712. Date of Electronic Publication: 2022 Feb 28.
Publication Type: Clinical Trial, Phase I; Journal Article; Randomized Controlled Trial
Journal Info: Publisher: Nature Publishing Company Country of Publication: United States NLM ID: 9502015 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-170X (Electronic) Linking ISSN: 10788956 NLM ISO Abbreviation: Nat Med Subsets: MEDLINE
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  Data: Nivolumab plus ipilimumab with or without live bacterial supplementation in metastatic renal cell carcinoma: a randomized phase 1 trial.
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  Data: <searchLink fieldCode="AU" term="%22Dizman+N%22">Dizman N</searchLink>; Department of Medical Oncology, City of Hope Comprehensive Cancer Center, Duarte, CA, USA.; Yale University School of Medicine, New Haven, CT, USA.<br /><searchLink fieldCode="AU" term="%22Meza+L%22">Meza L</searchLink>; Department of Medical Oncology, City of Hope Comprehensive Cancer Center, Duarte, CA, USA.<br /><searchLink fieldCode="AU" term="%22Bergerot+P%22">Bergerot P</searchLink>; Cettro Oncologia, Brasilia, Brazil.<br /><searchLink fieldCode="AU" term="%22Alcantara+M%22">Alcantara M</searchLink>; Department of Immunology, Beckman Research Institute, City of Hope Comprehensive Cancer Center, Duarte, CA, USA.<br /><searchLink fieldCode="AU" term="%22Dorff+T%22">Dorff T</searchLink>; Department of Medical Oncology, City of Hope Comprehensive Cancer Center, Duarte, CA, USA.<br /><searchLink fieldCode="AU" term="%22Lyou+Y%22">Lyou Y</searchLink>; Department of Medical Oncology, City of Hope Comprehensive Cancer Center, Duarte, CA, USA.<br /><searchLink fieldCode="AU" term="%22Frankel+P%22">Frankel P</searchLink>; Division of Biostatistics, City of Hope Comprehensive Cancer Center, Duarte, CA, USA.<br /><searchLink fieldCode="AU" term="%22Cui+Y%22">Cui Y</searchLink>; Division of Biostatistics, City of Hope Comprehensive Cancer Center, Duarte, CA, USA.<br /><searchLink fieldCode="AU" term="%22Mira+V%22">Mira V</searchLink>; Department of Medical Oncology, City of Hope Comprehensive Cancer Center, Duarte, CA, USA.<br /><searchLink fieldCode="AU" term="%22Llamas+M%22">Llamas M</searchLink>; Department of Medical Oncology, City of Hope Comprehensive Cancer Center, Duarte, CA, USA.<br /><searchLink fieldCode="AU" term="%22Hsu+J%22">Hsu J</searchLink>; Department of Medical Oncology, City of Hope Comprehensive Cancer Center, Duarte, CA, USA.<br /><searchLink fieldCode="AU" term="%22Zengin+Z%22">Zengin Z</searchLink>; Department of Medical Oncology, City of Hope Comprehensive Cancer Center, Duarte, CA, USA.<br /><searchLink fieldCode="AU" term="%22Salgia+N%22">Salgia N</searchLink>; Department of Medical Oncology, City of Hope Comprehensive Cancer Center, Duarte, CA, USA.<br /><searchLink fieldCode="AU" term="%22Salgia+S%22">Salgia S</searchLink>; Department of Medical Oncology, City of Hope Comprehensive Cancer Center, Duarte, CA, USA.<br /><searchLink fieldCode="AU" term="%22Malhotra+J%22">Malhotra J</searchLink>; Department of Medical Oncology, City of Hope Comprehensive Cancer Center, Duarte, CA, USA.<br /><searchLink fieldCode="AU" term="%22Chawla+N%22">Chawla N</searchLink>; Department of Medical Oncology, City of Hope Comprehensive Cancer Center, Duarte, CA, USA.<br /><searchLink fieldCode="AU" term="%22Chehrazi-Raffle+A%22">Chehrazi-Raffle A</searchLink>; Department of Medical Oncology, City of Hope Comprehensive Cancer Center, Duarte, CA, USA.<br /><searchLink fieldCode="AU" term="%22Muddasani+R%22">Muddasani R</searchLink>; Department of Medical Oncology, City of Hope Comprehensive Cancer Center, Duarte, CA, USA.<br /><searchLink fieldCode="AU" term="%22Gillece+J%22">Gillece J</searchLink>; The Translational Genomics Research Institute (TGen), Phoenix, AZ, USA.<br /><searchLink fieldCode="AU" term="%22Reining+L%22">Reining L</searchLink>; The Translational Genomics Research Institute (TGen), Phoenix, AZ, USA.<br /><searchLink fieldCode="AU" term="%22Trent+J%22">Trent J</searchLink>; The Translational Genomics Research Institute (TGen), Phoenix, AZ, USA.<br /><searchLink fieldCode="AU" term="%22Takahashi+M%22">Takahashi M</searchLink>; Miyarisan Pharmaceuticals, Co., Ltd., Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Oka+K%22">Oka K</searchLink>; Miyarisan Pharmaceuticals, Co., Ltd., Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Higashi+S%22">Higashi S</searchLink>; Miyarisan Pharmaceuticals, Co., Ltd., Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Kortylewski+M%22">Kortylewski M</searchLink>; Department of Immunology, Beckman Research Institute, City of Hope Comprehensive Cancer Center, Duarte, CA, USA.<br /><searchLink fieldCode="AU" term="%22Highlander+SK%22">Highlander SK</searchLink>; The Translational Genomics Research Institute (TGen), Phoenix, AZ, USA. sarah@skhighlander.us.<br /><searchLink fieldCode="AU" term="%22Pal+SK%22">Pal SK</searchLink>; Department of Medical Oncology, City of Hope Comprehensive Cancer Center, Duarte, CA, USA. spal@coh.org.
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  Data: <searchLink fieldCode="JN" term="%229502015%22">Nature medicine</searchLink> [Nat Med] 2022 Apr; Vol. 28 (4), pp. 704-712. <i>Date of Electronic Publication: </i>2022 Feb 28.
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