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Structure-guided changes at the V2 apex of HIV-1 clade C trimer enhance elicitation of autologous neutralizing and broad V1V2-scaffold antibodies.

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Title: Structure-guided changes at the V2 apex of HIV-1 clade C trimer enhance elicitation of autologous neutralizing and broad V1V2-scaffold antibodies.
Authors: Sahoo A; Emory Vaccine Center, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA; Department of Microbiology and Immunology, Emory School of Medicine, Emory University, Atlanta, GA 30322, USA., Hodge EA; Department of Medicinal Chemistry, University of Washington, Seattle, WA 98195, USA., LaBranche CC; Department of Surgery, Duke University Medical School, Duke University, Durham, NC 27710, USA., Styles TM; Emory Vaccine Center, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA; Department of Microbiology and Immunology, Emory School of Medicine, Emory University, Atlanta, GA 30322, USA., Shen X; Department of Surgery, Duke University Medical School, Duke University, Durham, NC 27710, USA., Cheedarla N; Emory Vaccine Center, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA; Department of Microbiology and Immunology, Emory School of Medicine, Emory University, Atlanta, GA 30322, USA., Shiferaw A; Emory Vaccine Center, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA; Department of Microbiology and Immunology, Emory School of Medicine, Emory University, Atlanta, GA 30322, USA., Ozorowski G; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, San Diego, CA 92121, USA., Lee WH; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, San Diego, CA 92121, USA., Ward AB; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, San Diego, CA 92121, USA., Tomaras GD; Department of Surgery, Duke University Medical School, Duke University, Durham, NC 27710, USA., Montefiori DC; Department of Surgery, Duke University Medical School, Duke University, Durham, NC 27710, USA., Irvine DJ; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Lee KK; Department of Medicinal Chemistry, University of Washington, Seattle, WA 98195, USA., Amara RR; Emory Vaccine Center, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA; Department of Microbiology and Immunology, Emory School of Medicine, Emory University, Atlanta, GA 30322, USA. Electronic address: ramara@emory.edu.
Source: Cell reports [Cell Rep] 2022 Mar 01; Vol. 38 (9), pp. 110436.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101573691 Publication Model: Print Cited Medium: Internet ISSN: 2211-1247 (Electronic) NLM ISO Abbreviation: Cell Rep Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Structure-guided changes at the V2 apex of HIV-1 clade C trimer enhance elicitation of autologous neutralizing and broad V1V2-scaffold antibodies.
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  Data: <searchLink fieldCode="AU" term="%22Sahoo+A%22">Sahoo A</searchLink>; Emory Vaccine Center, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA; Department of Microbiology and Immunology, Emory School of Medicine, Emory University, Atlanta, GA 30322, USA.<br /><searchLink fieldCode="AU" term="%22Hodge+EA%22">Hodge EA</searchLink>; Department of Medicinal Chemistry, University of Washington, Seattle, WA 98195, USA.<br /><searchLink fieldCode="AU" term="%22LaBranche+CC%22">LaBranche CC</searchLink>; Department of Surgery, Duke University Medical School, Duke University, Durham, NC 27710, USA.<br /><searchLink fieldCode="AU" term="%22Styles+TM%22">Styles TM</searchLink>; Emory Vaccine Center, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA; Department of Microbiology and Immunology, Emory School of Medicine, Emory University, Atlanta, GA 30322, USA.<br /><searchLink fieldCode="AU" term="%22Shen+X%22">Shen X</searchLink>; Department of Surgery, Duke University Medical School, Duke University, Durham, NC 27710, USA.<br /><searchLink fieldCode="AU" term="%22Cheedarla+N%22">Cheedarla N</searchLink>; Emory Vaccine Center, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA; Department of Microbiology and Immunology, Emory School of Medicine, Emory University, Atlanta, GA 30322, USA.<br /><searchLink fieldCode="AU" term="%22Shiferaw+A%22">Shiferaw A</searchLink>; Emory Vaccine Center, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA; Department of Microbiology and Immunology, Emory School of Medicine, Emory University, Atlanta, GA 30322, USA.<br /><searchLink fieldCode="AU" term="%22Ozorowski+G%22">Ozorowski G</searchLink>; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, San Diego, CA 92121, USA.<br /><searchLink fieldCode="AU" term="%22Lee+WH%22">Lee WH</searchLink>; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, San Diego, CA 92121, USA.<br /><searchLink fieldCode="AU" term="%22Ward+AB%22">Ward AB</searchLink>; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, San Diego, CA 92121, USA.<br /><searchLink fieldCode="AU" term="%22Tomaras+GD%22">Tomaras GD</searchLink>; Department of Surgery, Duke University Medical School, Duke University, Durham, NC 27710, USA.<br /><searchLink fieldCode="AU" term="%22Montefiori+DC%22">Montefiori DC</searchLink>; Department of Surgery, Duke University Medical School, Duke University, Durham, NC 27710, USA.<br /><searchLink fieldCode="AU" term="%22Irvine+DJ%22">Irvine DJ</searchLink>; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.<br /><searchLink fieldCode="AU" term="%22Lee+KK%22">Lee KK</searchLink>; Department of Medicinal Chemistry, University of Washington, Seattle, WA 98195, USA.<br /><searchLink fieldCode="AU" term="%22Amara+RR%22">Amara RR</searchLink>; Emory Vaccine Center, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA; Department of Microbiology and Immunology, Emory School of Medicine, Emory University, Atlanta, GA 30322, USA. Electronic address: ramara@emory.edu.
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  Data: <searchLink fieldCode="JN" term="%22101573691%22">Cell reports</searchLink> [Cell Rep] 2022 Mar 01; Vol. 38 (9), pp. 110436.
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              Text: 2022 Mar 01
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