Structure-guided changes at the V2 apex of HIV-1 clade C trimer enhance elicitation of autologous neutralizing and broad V1V2-scaffold antibodies.
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| Title: | Structure-guided changes at the V2 apex of HIV-1 clade C trimer enhance elicitation of autologous neutralizing and broad V1V2-scaffold antibodies. |
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| Authors: | Sahoo A; Emory Vaccine Center, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA; Department of Microbiology and Immunology, Emory School of Medicine, Emory University, Atlanta, GA 30322, USA., Hodge EA; Department of Medicinal Chemistry, University of Washington, Seattle, WA 98195, USA., LaBranche CC; Department of Surgery, Duke University Medical School, Duke University, Durham, NC 27710, USA., Styles TM; Emory Vaccine Center, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA; Department of Microbiology and Immunology, Emory School of Medicine, Emory University, Atlanta, GA 30322, USA., Shen X; Department of Surgery, Duke University Medical School, Duke University, Durham, NC 27710, USA., Cheedarla N; Emory Vaccine Center, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA; Department of Microbiology and Immunology, Emory School of Medicine, Emory University, Atlanta, GA 30322, USA., Shiferaw A; Emory Vaccine Center, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA; Department of Microbiology and Immunology, Emory School of Medicine, Emory University, Atlanta, GA 30322, USA., Ozorowski G; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, San Diego, CA 92121, USA., Lee WH; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, San Diego, CA 92121, USA., Ward AB; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, San Diego, CA 92121, USA., Tomaras GD; Department of Surgery, Duke University Medical School, Duke University, Durham, NC 27710, USA., Montefiori DC; Department of Surgery, Duke University Medical School, Duke University, Durham, NC 27710, USA., Irvine DJ; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Lee KK; Department of Medicinal Chemistry, University of Washington, Seattle, WA 98195, USA., Amara RR; Emory Vaccine Center, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA; Department of Microbiology and Immunology, Emory School of Medicine, Emory University, Atlanta, GA 30322, USA. Electronic address: ramara@emory.edu. |
| Source: | Cell reports [Cell Rep] 2022 Mar 01; Vol. 38 (9), pp. 110436. |
| Publication Type: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: Cell Press Country of Publication: United States NLM ID: 101573691 Publication Model: Print Cited Medium: Internet ISSN: 2211-1247 (Electronic) NLM ISO Abbreviation: Cell Rep Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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