Genome-wide association study reveals novel genetic loci: a new polygenic risk score for mitral valve prolapse.
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| Title: | Genome-wide association study reveals novel genetic loci: a new polygenic risk score for mitral valve prolapse. |
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| Authors: | Roselli C; Cardiovascular Disease Initiative, The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Yu M; Université de Paris, PARCC, Inserm, F-75015 Paris, France., Nauffal V; Cardiovascular Disease Initiative, The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Division of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, MA, USA., Georges A; Université de Paris, PARCC, Inserm, F-75015 Paris, France., Yang Q; School of Public Health, Boston University, Boston, MA, USA., Love K; Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA., Weng LC; Cardiovascular Disease Initiative, The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA., Delling FN; Division of Cardiology, University of California San Francisco, San Francisco, CA, USA., Maurya SR; Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, København 2200, Denmark., Schrölkamp M; Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, København 2200, Denmark., Tfelt-Hansen J; Department of Cardiology, The Heart Centre, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.; Department of Forensic Medicine, Faculty of Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Hagège A; Université de Paris, PARCC, Inserm, F-75015 Paris, France.; Assistance Publique-Hôpitaux de Paris, Departments of Cardiology and Genetics, Hôpital Européen Georges Pompidou, 75015 Paris, France., Jeunemaitre X; Université de Paris, PARCC, Inserm, F-75015 Paris, France.; Assistance Publique-Hôpitaux de Paris, Departments of Cardiology and Genetics, Hôpital Européen Georges Pompidou, 75015 Paris, France., Debette S; Bordeaux Population Health Research Center, Inserm Center U1219, University of Bordeaux, Bordeaux, France.; Department of Neurology, Bordeaux University Hospital, Inserm U1219, Bordeaux, France., Amouyel P; Univ. Lille, Inserm, Centre Hosp. Univ Lille, Institut Pasteur de Lille, UMR1167 - RID-AGE- Risk factors and molecular determinants of aging-related diseases, F-59000 Lille, France., Guan W; Cardiovascular Disease Initiative, The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA.; Demoulas Center for Cardiac Arrhythmias, Massachusetts General Hospital, Boston, MA, USA., Muehlschlegel JD; Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Boston, MA, USA., Body SC; Department of Anesthesiology, Boston University School of Medicine, Boston, MA, USA., Shah S; Duke Molecular Physiology Institute, Duke University, Durham, NC, USA.; Division of Cardiology, Department of Medicine, Duke University School of Medicine, Durham, NC, USA., Samad Z; Division of Cardiology, Department of Medicine, Duke University School of Medicine, Durham, NC, USA.; Department of Medicine, Aga Khan University, Karachi, Pakistan., Kyryachenko S; Université de Paris, PARCC, Inserm, F-75015 Paris, France., Haynes C; Duke Molecular Physiology Institute, Duke University, Durham, NC, USA., Rienstra M; Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Le Tourneau T; l'institut du thorax, INSERM, CNRS, Univ Nantes, CHU Nantes, Nantes, France.; l'institut du thorax, CHU Nantes, Nantes, France., Probst V; l'institut du thorax, INSERM, CNRS, Univ Nantes, CHU Nantes, Nantes, France., Roussel R; Cordeliers Research Centre, ImMeDiab Team, INSERM, Université de Paris, Paris, France.; Hôpital Bichat-Claude-Bernard, APHP, Department of Diabetology, Paris, France., Wijdh-Den Hamer IJ; Department of Cardiothoracic Surgery, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Siland JE; Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Knowlton KU; Intermountain Medical Center Heart Institute, Salt Lake City, UT, USA.; Division of Cardiovascular Medicine, Department of Medicine, University of California San Diego, San Diego, CA, USA., Jacques Schott J; l'institut du thorax, INSERM, CNRS, Univ Nantes, CHU Nantes, Nantes, France., Levine RA; Cardiac Ultrasound Laboratory, Harvard Medical School, Massachusetts General Hospital, Boston, MA, USA., Benjamin EJ; National Heart, Lung, and Blood Institute's and Boston University's, The Framingham Heart Study, Framingham, MA, USA.; Section of Cardiovascular Medicine, Boston University School of Medicine, Boston, MA, USA.; Department of Epidemiology, Boston University School of Public Health, Boston, MA, USA., Vasan RS; School of Public Health, Boston University, Boston, MA, USA.; National Heart, Lung, and Blood Institute's and Boston University's, The Framingham Heart Study, Framingham, MA, USA.; School of Medicine, Boston University, Boston, MA, USA., Horne BD; Intermountain Medical Center Heart Institute, Salt Lake City, UT, USA.; Division of Cardiovascular Medicine, Department of Medicine, Stanford University, Stanford, CA, USA., Muhlestein JB; Intermountain Medical Center Heart Institute, Salt Lake City, UT, USA.; Cardiology Division, Department of Internal Medicine, University of Utah, Salt Lake City, UT, USA., Benfari G; Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA., Enriquez-Sarano M; Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA., Natale A; Texas Cardiac Arrhythmia Institute, St David's Medical Center, Austin, TX, USA., Mohanty S; Texas Cardiac Arrhythmia Institute, St David's Medical Center, Austin, TX, USA., Trivedi C; Texas Cardiac Arrhythmia Institute, St David's Medical Center, Austin, TX, USA., Shoemaker MB; Department of Medicine, Division of Cardiovascular Diseases, Vanderbilt University Medical Center, Nashville, TN, USA., Yoneda ZT; Department of Medicine, Division of Cardiovascular Diseases, Vanderbilt University Medical Center, Nashville, TN, USA., Wells QS; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Pharmacology, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA., Baker MT; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Farber-Eger E; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Michelena HI; Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA., Lundby A; Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, København 2200, Denmark.; The Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, København 2200, Denmark., Norris RA; Cardiovascular Developmental Biology Center, Department of Regenerative Medicine and Cell Biology, Medical University of South Carolina, Charleston, SC, USA., Slaugenhaupt SA; Center for Genomic Medicine and Department of Neurology, Massachusetts General Hospital Research Institute and Harvard Medical School, Boston, MA, USA., Dina C; l'institut du thorax, INSERM, CNRS, Univ Nantes, CHU Nantes, Nantes, France., Lubitz SA; Cardiovascular Disease Initiative, The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA.; Demoulas Center for Cardiac Arrhythmias, Massachusetts General Hospital, Boston, MA, USA., Bouatia-Naji N; Université de Paris, PARCC, Inserm, F-75015 Paris, France., Ellinor PT; Cardiovascular Disease Initiative, The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA.; Demoulas Center for Cardiac Arrhythmias, Massachusetts General Hospital, Boston, MA, USA., Milan DJ; Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA.; Leducq Foundation, Boston, MA 02110, USA. |
| Source: | European heart journal [Eur Heart J] 2022 May 01; Vol. 43 (17), pp. 1668-1680. |
| Publication Type: | Journal Article; Meta-Analysis; Research Support, N.I.H., Extramural |
| Journal Info: | Publisher: Oxford University Press Country of Publication: England NLM ID: 8006263 Publication Model: Print Cited Medium: Internet ISSN: 1522-9645 (Electronic) Linking ISSN: 0195668X NLM ISO Abbreviation: Eur Heart J Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1522-9645 |
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| DOI: | 10.1093/eurheartj/ehac049 |
