The C terminus of the mycobacterium ESX-1 secretion system substrate ESAT-6 is required for phagosomal membrane damage and virulence. - Osman MM; Shanahan JK; Chu F; Takaki KK; Pinckert ML; Pagán AJ; Brosch R; Conrad WH; Ramakrishnan L (Proceedings of the National Academy of Sciences of the United States of America, 2022)