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Large-scale design and refinement of stable proteins using sequence-only models.

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Title: Large-scale design and refinement of stable proteins using sequence-only models.
Authors: Singer JM; Two Six Technologies, Arlington, Virginia, United States of America., Novotney S; Two Six Technologies, Arlington, Virginia, United States of America., Strickland D; Department of Electrical and Computer Engineering, University of Washington, Seattle, Washington, United States of America., Haddox HK; Department of Biochemistry and Institute for Protein Design, University of Washington, Seattle, Washington, United States of America., Leiby N; Two Six Technologies, Arlington, Virginia, United States of America., Rocklin GJ; Department of Pharmacology and Center for Synthetic Biology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America., Chow CM; Department of Biochemistry and Institute for Protein Design, University of Washington, Seattle, Washington, United States of America., Roy A; Department of Biochemistry and Institute for Protein Design, University of Washington, Seattle, Washington, United States of America., Bera AK; Department of Biochemistry and Institute for Protein Design, University of Washington, Seattle, Washington, United States of America., Motta FC; Department of Mathematical Sciences, Florida Atlantic University, Boca Raton, Florida, United States of America., Cao L; Department of Biochemistry and Institute for Protein Design, University of Washington, Seattle, Washington, United States of America., Strauch EM; Department of Pharmaceutical and Biomedical Sciences, University of Georgia, Athens, Georgia, United States of America., Chidyausiku TM; Department of Biochemistry and Institute for Protein Design, University of Washington, Seattle, Washington, United States of America., Ford A; Department of Biochemistry and Institute for Protein Design, University of Washington, Seattle, Washington, United States of America., Ho E; Texas Advanced Computing Center, Austin, Texas, United States of America., Zaitzeff A; Two Six Technologies, Arlington, Virginia, United States of America., Mackenzie CO; Quantitative Biomedical Sciences Graduate Program, Dartmouth College, Hanover, New Hampshire, United States of America., Eramian H; Netrias, Cambridge, Massachusetts, United States of America., DiMaio F; Department of Biochemistry and Institute for Protein Design, University of Washington, Seattle, Washington, United States of America., Grigoryan G; Departments of Computer Science and Biological Sciences, Dartmouth College, Hanover, New Hampshire, United States of America., Vaughn M; Texas Advanced Computing Center, Austin, Texas, United States of America., Stewart LJ; Department of Biochemistry and Institute for Protein Design, University of Washington, Seattle, Washington, United States of America., Baker D; Department of Biochemistry and Institute for Protein Design, University of Washington, Seattle, Washington, United States of America., Klavins E; Department of Electrical and Computer Engineering, University of Washington, Seattle, Washington, United States of America.
Source: PloS one [PLoS One] 2022 Mar 14; Vol. 17 (3), pp. e0265020. Date of Electronic Publication: 2022 Mar 14 (Print Publication: 2022).
Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
Journal Info: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Large-scale design and refinement of stable proteins using sequence-only models.
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  Data: <searchLink fieldCode="AU" term="%22Singer+JM%22">Singer JM</searchLink>; Two Six Technologies, Arlington, Virginia, United States of America.<br /><searchLink fieldCode="AU" term="%22Novotney+S%22">Novotney S</searchLink>; Two Six Technologies, Arlington, Virginia, United States of America.<br /><searchLink fieldCode="AU" term="%22Strickland+D%22">Strickland D</searchLink>; Department of Electrical and Computer Engineering, University of Washington, Seattle, Washington, United States of America.<br /><searchLink fieldCode="AU" term="%22Haddox+HK%22">Haddox HK</searchLink>; Department of Biochemistry and Institute for Protein Design, University of Washington, Seattle, Washington, United States of America.<br /><searchLink fieldCode="AU" term="%22Leiby+N%22">Leiby N</searchLink>; Two Six Technologies, Arlington, Virginia, United States of America.<br /><searchLink fieldCode="AU" term="%22Rocklin+GJ%22">Rocklin GJ</searchLink>; Department of Pharmacology and Center for Synthetic Biology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America.<br /><searchLink fieldCode="AU" term="%22Chow+CM%22">Chow CM</searchLink>; Department of Biochemistry and Institute for Protein Design, University of Washington, Seattle, Washington, United States of America.<br /><searchLink fieldCode="AU" term="%22Roy+A%22">Roy A</searchLink>; Department of Biochemistry and Institute for Protein Design, University of Washington, Seattle, Washington, United States of America.<br /><searchLink fieldCode="AU" term="%22Bera+AK%22">Bera AK</searchLink>; Department of Biochemistry and Institute for Protein Design, University of Washington, Seattle, Washington, United States of America.<br /><searchLink fieldCode="AU" term="%22Motta+FC%22">Motta FC</searchLink>; Department of Mathematical Sciences, Florida Atlantic University, Boca Raton, Florida, United States of America.<br /><searchLink fieldCode="AU" term="%22Cao+L%22">Cao L</searchLink>; Department of Biochemistry and Institute for Protein Design, University of Washington, Seattle, Washington, United States of America.<br /><searchLink fieldCode="AU" term="%22Strauch+EM%22">Strauch EM</searchLink>; Department of Pharmaceutical and Biomedical Sciences, University of Georgia, Athens, Georgia, United States of America.<br /><searchLink fieldCode="AU" term="%22Chidyausiku+TM%22">Chidyausiku TM</searchLink>; Department of Biochemistry and Institute for Protein Design, University of Washington, Seattle, Washington, United States of America.<br /><searchLink fieldCode="AU" term="%22Ford+A%22">Ford A</searchLink>; Department of Biochemistry and Institute for Protein Design, University of Washington, Seattle, Washington, United States of America.<br /><searchLink fieldCode="AU" term="%22Ho+E%22">Ho E</searchLink>; Texas Advanced Computing Center, Austin, Texas, United States of America.<br /><searchLink fieldCode="AU" term="%22Zaitzeff+A%22">Zaitzeff A</searchLink>; Two Six Technologies, Arlington, Virginia, United States of America.<br /><searchLink fieldCode="AU" term="%22Mackenzie+CO%22">Mackenzie CO</searchLink>; Quantitative Biomedical Sciences Graduate Program, Dartmouth College, Hanover, New Hampshire, United States of America.<br /><searchLink fieldCode="AU" term="%22Eramian+H%22">Eramian H</searchLink>; Netrias, Cambridge, Massachusetts, United States of America.<br /><searchLink fieldCode="AU" term="%22DiMaio+F%22">DiMaio F</searchLink>; Department of Biochemistry and Institute for Protein Design, University of Washington, Seattle, Washington, United States of America.<br /><searchLink fieldCode="AU" term="%22Grigoryan+G%22">Grigoryan G</searchLink>; Departments of Computer Science and Biological Sciences, Dartmouth College, Hanover, New Hampshire, United States of America.<br /><searchLink fieldCode="AU" term="%22Vaughn+M%22">Vaughn M</searchLink>; Texas Advanced Computing Center, Austin, Texas, United States of America.<br /><searchLink fieldCode="AU" term="%22Stewart+LJ%22">Stewart LJ</searchLink>; Department of Biochemistry and Institute for Protein Design, University of Washington, Seattle, Washington, United States of America.<br /><searchLink fieldCode="AU" term="%22Baker+D%22">Baker D</searchLink>; Department of Biochemistry and Institute for Protein Design, University of Washington, Seattle, Washington, United States of America.<br /><searchLink fieldCode="AU" term="%22Klavins+E%22">Klavins E</searchLink>; Department of Electrical and Computer Engineering, University of Washington, Seattle, Washington, United States of America.
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  Data: <searchLink fieldCode="JN" term="%22101285081%22">PloS one</searchLink> [PLoS One] 2022 Mar 14; Vol. 17 (3), pp. e0265020. <i>Date of Electronic Publication: </i>2022 Mar 14 (<i>Print Publication: </i>2022).
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