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Exploring the safety, effect on the tumor microenvironment, and efficacy of itacitinib in combination with epacadostat or parsaclisib in advanced solid tumors: a phase I study.

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Title: Exploring the safety, effect on the tumor microenvironment, and efficacy of itacitinib in combination with epacadostat or parsaclisib in advanced solid tumors: a phase I study.
Authors: Naing A; Department of Investigational Cancer Therapeutics, MD Anderson Cancer Center, Houston, Texas, USA anaing@mdanderson.org., Powderly JD; Cancer Research Clinic, Carolina Biooncology Institute, Huntersville, North Carolina, USA., Nemunaitis JJ; University of Toledo College of Medicine, Toledo, Ohio, USA., Luke JJ; Division of Hematology/Oncology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA., Mansfield AS; Oncology, Mayo Clinic, Rochester, Minnesota, USA., Messersmith WA; School of Medicine, University of Colorado, Aurora, Colorado, USA., Sahebjam S; Clinical Research Unit, Moffitt Cancer Center, Tampa, Florida, USA., LoRusso PM; Yale School of Medicine, Yale Cancer Center, New Haven, Connecticut, USA., Garrido-Laguna I; University of Utah School of Medicine, Huntsman Cancer Institute, Salt Lake City, Utah, USA., Leopold L; Immuno-Oncology, Incyte Corporation, Wilmington, Delaware, USA., Geschwindt R; Immuno-Oncology, Incyte Corporation, Wilmington, Delaware, USA., Ding K; Biostatistics, Incyte Corporation, Wilmington, Delaware, USA., Smith M; Immuno-Oncology, Incyte Corporation, Wilmington, Delaware, USA., Berlin JD; Division of Hematology/Oncology, Vanderbilt University, Nashville, Tennessee, USA.
Source: Journal for immunotherapy of cancer [J Immunother Cancer] 2022 Mar; Vol. 10 (3).
Publication Type: Clinical Trial, Phase I; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
Journal Info: Publisher: BMJ Publishing Group Ltd Country of Publication: England NLM ID: 101620585 Publication Model: Print Cited Medium: Internet ISSN: 2051-1426 (Electronic) Linking ISSN: 20511426 NLM ISO Abbreviation: J Immunother Cancer Subsets: MEDLINE
Database: MEDLINE Ultimate
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PubType: Academic Journal
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  Data: Exploring the safety, effect on the tumor microenvironment, and efficacy of itacitinib in combination with epacadostat or parsaclisib in advanced solid tumors: a phase I study.
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  Data: <searchLink fieldCode="AU" term="%22Naing+A%22">Naing A</searchLink>; Department of Investigational Cancer Therapeutics, MD Anderson Cancer Center, Houston, Texas, USA anaing@mdanderson.org.<br /><searchLink fieldCode="AU" term="%22Powderly+JD%22">Powderly JD</searchLink>; Cancer Research Clinic, Carolina Biooncology Institute, Huntersville, North Carolina, USA.<br /><searchLink fieldCode="AU" term="%22Nemunaitis+JJ%22">Nemunaitis JJ</searchLink>; University of Toledo College of Medicine, Toledo, Ohio, USA.<br /><searchLink fieldCode="AU" term="%22Luke+JJ%22">Luke JJ</searchLink>; Division of Hematology/Oncology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Mansfield+AS%22">Mansfield AS</searchLink>; Oncology, Mayo Clinic, Rochester, Minnesota, USA.<br /><searchLink fieldCode="AU" term="%22Messersmith+WA%22">Messersmith WA</searchLink>; School of Medicine, University of Colorado, Aurora, Colorado, USA.<br /><searchLink fieldCode="AU" term="%22Sahebjam+S%22">Sahebjam S</searchLink>; Clinical Research Unit, Moffitt Cancer Center, Tampa, Florida, USA.<br /><searchLink fieldCode="AU" term="%22LoRusso+PM%22">LoRusso PM</searchLink>; Yale School of Medicine, Yale Cancer Center, New Haven, Connecticut, USA.<br /><searchLink fieldCode="AU" term="%22Garrido-Laguna+I%22">Garrido-Laguna I</searchLink>; University of Utah School of Medicine, Huntsman Cancer Institute, Salt Lake City, Utah, USA.<br /><searchLink fieldCode="AU" term="%22Leopold+L%22">Leopold L</searchLink>; Immuno-Oncology, Incyte Corporation, Wilmington, Delaware, USA.<br /><searchLink fieldCode="AU" term="%22Geschwindt+R%22">Geschwindt R</searchLink>; Immuno-Oncology, Incyte Corporation, Wilmington, Delaware, USA.<br /><searchLink fieldCode="AU" term="%22Ding+K%22">Ding K</searchLink>; Biostatistics, Incyte Corporation, Wilmington, Delaware, USA.<br /><searchLink fieldCode="AU" term="%22Smith+M%22">Smith M</searchLink>; Immuno-Oncology, Incyte Corporation, Wilmington, Delaware, USA.<br /><searchLink fieldCode="AU" term="%22Berlin+JD%22">Berlin JD</searchLink>; Division of Hematology/Oncology, Vanderbilt University, Nashville, Tennessee, USA.
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  Data: <searchLink fieldCode="JN" term="%22101620585%22">Journal for immunotherapy of cancer</searchLink> [J Immunother Cancer] 2022 Mar; Vol. 10 (3).
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  Data: Clinical Trial, Phase I; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BMJ+Publishing+Group+Ltd%22">BMJ Publishing Group Ltd </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101620585 <i>Publication Model: </i>Print <i>Cited Medium: </i>Internet <i>ISSN: </i>2051-1426 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2220511426%22">20511426 </searchLink><i>NLM ISO Abbreviation: </i>J Immunother Cancer <i>Subsets: </i>MEDLINE
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        Value: 10.1136/jitc-2021-004223
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        Text: English
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              Text: 2022 Mar
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