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Single-cell transcriptomics reveals a distinct developmental state of KMT2A-rearranged infant B-cell acute lymphoblastic leukemia.

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Title: Single-cell transcriptomics reveals a distinct developmental state of KMT2A-rearranged infant B-cell acute lymphoblastic leukemia.
Authors: Khabirova E; Wellcome Sanger Institute, Hinxton, UK., Jardine L; Biosciences Institute, Newcastle University, Newcastle upon Tyne, UK.; Haematology Department, Freeman Hospital, Newcastle-upon-Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK., Coorens THH; Wellcome Sanger Institute, Hinxton, UK., Webb S; Biosciences Institute, Newcastle University, Newcastle upon Tyne, UK., Treger TD; Wellcome Sanger Institute, Hinxton, UK.; Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.; Department of Paediatrics, University of Cambridge, Cambridge, UK., Engelbert J; Biosciences Institute, Newcastle University, Newcastle upon Tyne, UK., Porter T; Wellcome Sanger Institute, Hinxton, UK., Prigmore E; Wellcome Sanger Institute, Hinxton, UK., Collord G; Wellcome Sanger Institute, Hinxton, UK.; Department of Haematology, University College London Hospital, London, UK.; Department of Haematology, University College London Cancer Institute, London, UK., Piapi A; Great Ormond Street Hospital for Children NHS Foundation Trust and NIHR Great Ormond Street Hospital Biomedical Research Centre, London, UK., Teichmann SA; Wellcome Sanger Institute, Hinxton, UK., Inglott S; Great Ormond Street Hospital for Children NHS Foundation Trust and NIHR Great Ormond Street Hospital Biomedical Research Centre, London, UK., Williams O; UCL Great Ormond Street Institute of Child Health, London, UK., Heidenreich O; Princess Maxima Center for Pediatric Oncology, Utrecht, the Netherlands.; Wolfson Childhood Cancer Research Centre, Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK., Young MD; Wellcome Sanger Institute, Hinxton, UK., Straathof K; Great Ormond Street Hospital for Children NHS Foundation Trust and NIHR Great Ormond Street Hospital Biomedical Research Centre, London, UK.; UCL Great Ormond Street Institute of Child Health, London, UK., Bomken S; Wolfson Childhood Cancer Research Centre, Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK. s.n.bomken@newcastle.ac.uk.; The Great North Children's Hospital, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK. s.n.bomken@newcastle.ac.uk., Bartram J; Great Ormond Street Hospital for Children NHS Foundation Trust and NIHR Great Ormond Street Hospital Biomedical Research Centre, London, UK. Jack.Bartram@gosh.nhs.uk.; UCL Great Ormond Street Institute of Child Health, London, UK. Jack.Bartram@gosh.nhs.uk., Haniffa M; Wellcome Sanger Institute, Hinxton, UK. m.a.haniffa@newcastle.ac.uk.; Biosciences Institute, Newcastle University, Newcastle upon Tyne, UK. m.a.haniffa@newcastle.ac.uk.; Department of Dermatology and NIHR Newcastle Biomedical Research Centre, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK. m.a.haniffa@newcastle.ac.uk., Behjati S; Wellcome Sanger Institute, Hinxton, UK. sb31@sanger.ac.uk.; Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK. sb31@sanger.ac.uk.; Department of Paediatrics, University of Cambridge, Cambridge, UK. sb31@sanger.ac.uk.
Source: Nature medicine [Nat Med] 2022 Apr; Vol. 28 (4), pp. 743-751. Date of Electronic Publication: 2022 Mar 14.
Publication Type: Journal Article; Meta-Analysis; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Publishing Company Country of Publication: United States NLM ID: 9502015 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-170X (Electronic) Linking ISSN: 10788956 NLM ISO Abbreviation: Nat Med Subsets: MEDLINE
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  Data: Single-cell transcriptomics reveals a distinct developmental state of KMT2A-rearranged infant B-cell acute lymphoblastic leukemia.
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  Data: <searchLink fieldCode="AU" term="%22Khabirova+E%22">Khabirova E</searchLink>; Wellcome Sanger Institute, Hinxton, UK.<br /><searchLink fieldCode="AU" term="%22Jardine+L%22">Jardine L</searchLink>; Biosciences Institute, Newcastle University, Newcastle upon Tyne, UK.; Haematology Department, Freeman Hospital, Newcastle-upon-Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK.<br /><searchLink fieldCode="AU" term="%22Coorens+THH%22">Coorens THH</searchLink>; Wellcome Sanger Institute, Hinxton, UK.<br /><searchLink fieldCode="AU" term="%22Webb+S%22">Webb S</searchLink>; Biosciences Institute, Newcastle University, Newcastle upon Tyne, UK.<br /><searchLink fieldCode="AU" term="%22Treger+TD%22">Treger TD</searchLink>; Wellcome Sanger Institute, Hinxton, UK.; Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.; Department of Paediatrics, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Engelbert+J%22">Engelbert J</searchLink>; Biosciences Institute, Newcastle University, Newcastle upon Tyne, UK.<br /><searchLink fieldCode="AU" term="%22Porter+T%22">Porter T</searchLink>; Wellcome Sanger Institute, Hinxton, UK.<br /><searchLink fieldCode="AU" term="%22Prigmore+E%22">Prigmore E</searchLink>; Wellcome Sanger Institute, Hinxton, UK.<br /><searchLink fieldCode="AU" term="%22Collord+G%22">Collord G</searchLink>; Wellcome Sanger Institute, Hinxton, UK.; Department of Haematology, University College London Hospital, London, UK.; Department of Haematology, University College London Cancer Institute, London, UK.<br /><searchLink fieldCode="AU" term="%22Piapi+A%22">Piapi A</searchLink>; Great Ormond Street Hospital for Children NHS Foundation Trust and NIHR Great Ormond Street Hospital Biomedical Research Centre, London, UK.<br /><searchLink fieldCode="AU" term="%22Teichmann+SA%22">Teichmann SA</searchLink>; Wellcome Sanger Institute, Hinxton, UK.<br /><searchLink fieldCode="AU" term="%22Inglott+S%22">Inglott S</searchLink>; Great Ormond Street Hospital for Children NHS Foundation Trust and NIHR Great Ormond Street Hospital Biomedical Research Centre, London, UK.<br /><searchLink fieldCode="AU" term="%22Williams+O%22">Williams O</searchLink>; UCL Great Ormond Street Institute of Child Health, London, UK.<br /><searchLink fieldCode="AU" term="%22Heidenreich+O%22">Heidenreich O</searchLink>; Princess Maxima Center for Pediatric Oncology, Utrecht, the Netherlands.; Wolfson Childhood Cancer Research Centre, Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK.<br /><searchLink fieldCode="AU" term="%22Young+MD%22">Young MD</searchLink>; Wellcome Sanger Institute, Hinxton, UK.<br /><searchLink fieldCode="AU" term="%22Straathof+K%22">Straathof K</searchLink>; Great Ormond Street Hospital for Children NHS Foundation Trust and NIHR Great Ormond Street Hospital Biomedical Research Centre, London, UK.; UCL Great Ormond Street Institute of Child Health, London, UK.<br /><searchLink fieldCode="AU" term="%22Bomken+S%22">Bomken S</searchLink>; Wolfson Childhood Cancer Research Centre, Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK. s.n.bomken@newcastle.ac.uk.; The Great North Children's Hospital, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK. s.n.bomken@newcastle.ac.uk.<br /><searchLink fieldCode="AU" term="%22Bartram+J%22">Bartram J</searchLink>; Great Ormond Street Hospital for Children NHS Foundation Trust and NIHR Great Ormond Street Hospital Biomedical Research Centre, London, UK. Jack.Bartram@gosh.nhs.uk.; UCL Great Ormond Street Institute of Child Health, London, UK. Jack.Bartram@gosh.nhs.uk.<br /><searchLink fieldCode="AU" term="%22Haniffa+M%22">Haniffa M</searchLink>; Wellcome Sanger Institute, Hinxton, UK. m.a.haniffa@newcastle.ac.uk.; Biosciences Institute, Newcastle University, Newcastle upon Tyne, UK. m.a.haniffa@newcastle.ac.uk.; Department of Dermatology and NIHR Newcastle Biomedical Research Centre, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK. m.a.haniffa@newcastle.ac.uk.<br /><searchLink fieldCode="AU" term="%22Behjati+S%22">Behjati S</searchLink>; Wellcome Sanger Institute, Hinxton, UK. sb31@sanger.ac.uk.; Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK. sb31@sanger.ac.uk.; Department of Paediatrics, University of Cambridge, Cambridge, UK. sb31@sanger.ac.uk.
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