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Tumor Derived Extracellular Vesicles Drive T Cell Exhaustion in Tumor Microenvironment through Sphingosine Mediated Signaling and Impacting Immunotherapy Outcomes in Ovarian Cancer.

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Title: Tumor Derived Extracellular Vesicles Drive T Cell Exhaustion in Tumor Microenvironment through Sphingosine Mediated Signaling and Impacting Immunotherapy Outcomes in Ovarian Cancer.
Authors: Gupta P; Department of Obstetrics and Gynecology, Medical College of Wisconsin, Milwaukee, Wisconsin, 53226, USA., Kadamberi IP; Department of Obstetrics and Gynecology, Medical College of Wisconsin, Milwaukee, Wisconsin, 53226, USA., Mittal S; Department of Obstetrics and Gynecology, Medical College of Wisconsin, Milwaukee, Wisconsin, 53226, USA., Tsaih SW; Department of Obstetrics and Gynecology, Medical College of Wisconsin, Milwaukee, Wisconsin, 53226, USA., George J; Department of Obstetrics and Gynecology, Medical College of Wisconsin, Milwaukee, Wisconsin, 53226, USA., Kumar S; Department of Obstetrics and Gynecology, Medical College of Wisconsin, Milwaukee, Wisconsin, 53226, USA., Vijayan DK; Laboratory for computational and structural biology, Jubilee Center for Medical Research, Thrissur, Kerala, 680006, India.; Laboratory for Structural Bioinformatics, Center for Biosystems Dynamics Research, Riken, 230-0045, Japan., Geethadevi A; Department of Obstetrics and Gynecology, Medical College of Wisconsin, Milwaukee, Wisconsin, 53226, USA., Parashar D; Department of Obstetrics and Gynecology, Medical College of Wisconsin, Milwaukee, Wisconsin, 53226, USA., Topchyan P; Department of Microbiology and Immunology, MCW and Versiti Blood Research Institute, Milwaukee, Wisconsin, 53226, USA., McAlarnen L; Department of Obstetrics and Gynecology, Medical College of Wisconsin, Milwaukee, Wisconsin, 53226, USA., Volkman BF; Department of Biochemistry, Medical College of Wisconsin, Milwaukee, 53226, USA., Cui W; Department of Microbiology and Immunology, MCW and Versiti Blood Research Institute, Milwaukee, Wisconsin, 53226, USA., Zhang KYJ; Laboratory for Structural Bioinformatics, Center for Biosystems Dynamics Research, Riken, 230-0045, Japan., Di Vizio D; Department of Surgery, Pathology and Laboratory Medicine, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA., Chaluvally-Raghavan P; Department of Obstetrics and Gynecology, Medical College of Wisconsin, Milwaukee, Wisconsin, 53226, USA.; Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin, 53226, USA.; Medical College of Wisconsin Cancer Center, Medical College of Wisconsin, Milwaukee, Wisconsin, 53226, USA., Pradeep S; Department of Obstetrics and Gynecology, Medical College of Wisconsin, Milwaukee, Wisconsin, 53226, USA.; Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin, 53226, USA.; Medical College of Wisconsin Cancer Center, Medical College of Wisconsin, Milwaukee, Wisconsin, 53226, USA.
Source: Advanced science (Weinheim, Baden-Wurttemberg, Germany) [Adv Sci (Weinh)] 2022 May; Vol. 9 (14), pp. e2104452. Date of Electronic Publication: 2022 Mar 15.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: WILEY-VCH Country of Publication: Germany NLM ID: 101664569 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2198-3844 (Electronic) Linking ISSN: 21983844 NLM ISO Abbreviation: Adv Sci (Weinh) Subsets: MEDLINE
Database: MEDLINE Ultimate
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